Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors.

This study aims to compare the sleep characteristics (structure and quality) in patients with type-2 diabetes mellitus with and without diabetic neuropathic pain (DNP), and to investigate the relationship of sensory phenotypes, anxiety, and depression with sleep quality in DNP patients. A cross-sectional study was performed in patients with type-2 diabetes mellitus and neuropathy. Patients were classified into two groups-with or without neuropathic pain-according to the "Douleur Neuropathique-4 (DN4)" scale. Sleep characteristics and quality (Medical Outcomes Study-MOS-sleep), pain phenotype (Neuropathic Pain Symptom Inventory-NPSI), mood status (Hospital Anxiety and Depression scale-HADS), pain intensity (Visual Analogue Scale-VAS), and quality of life (SF-12v2) were measured. The sample included 130 patients (65 with DNP). The mean scores in all the dimensions of the MOS-sleep scale were higher (more disturbances) in the DNP patients. Higher scores in anxiety or depression, greater intensity of pain or a higher score in the paroxysmal pain phenotype were associated with lower sleep quality in DNP patients. A shorter duration of the diabetes and lower levels of glycated hemoglobin were also associated with lower sleep quality. The results show the relationship between DNP and sleep quality, and the importance of assessing sensory phenotypes and mental comorbidities in these patients. Taking these factors into consideration, to adopt a multimodal approach is necessary to achieve better clinical results.

Relationship between diabetic neuropathic pain and comorbidity. Their impact on pain intensity, diabetes complications and quality of life in patients with type-2 diabetes mellitus.

OBJECTIVE: To compare cognitive function, mood and sleep status in patients with and without diabetic neuropathic pain (DNP) and their relationship with pain intensity, diabetes complications, and quality of life. To determine whether these relationships differ depending on the sensorial phenotype. METHODS: Cross-sectional study performed on patients with type-2 diabetes-mellitus and neuropathy. Presence of DNP, pain intensity and phenotype, mood status, sleep characteristics and quality of life were measured. RESULTS: A total of 130 patients (65 with DNP) were included. DNP was related to poor sleep quality (OR = 1.03;CI95%:1.02-1.05), pain treatment (OR = 3.00,CI95%:1.24-7.29) or previous anxiety (OR = 2.70,CI95%:1.05-6.99). Patients with specific phenotypes or depression (=0.82,CI95%:-0.02-1.67) referred more severe pain. More complications were related to older age (OR = 1.40,CI95%:1.12-1.66), higher pain intensity (OR = 1.51,CI95%:1.00-2.28), lower cognitive performance (OR = 1.25,CI95%:1.09-1.43), previous anxiety (OR = 10.48,CI95%:1.46-75.24) and insulin treatment (OR = 124.50,CI95%:6.64-2335.06). Decrease in mental quality of life was associated with sleep disorders (ß = -0.33,CI95%:-0.48,-0.23), physical comorbidities (ß = -9.73,CI95%:-18.15, -1.31) and previous anxiety (ß = -7.91,CI95%:-13.04, -2.77). Lower scores in physical quality of life were related to sleep disorders (ß = -0.12,CI95%:-0.21, -0.18), obesity (ß = -8.35,CI95%:-13.16, -3.55), longer time since diagnosis (ß = -0.72,CI95%:-1.44;0.01) and disability (ß = -14.58,CI95%:-24.69; -4.48). CONCLUSIONS: The results support the idea that mental comorbidity and sleep disorders are factors associated with DNP and greater pain intensity, more diabetes complications and lower quality of life. Moreover, they highlight the relationship between sensorial phenotypes and pain intensity, and lower cognitive performance and diabetes complications.

Anxiety, depression and sleep disorders in patients with diabetic neuropathic pain: a systematic review.

Introduction: Diabetic neuropathic pain (DNP) is a disabling complication suffered by patients with diabetic neuropathy. DNP coexists with different conditions, especially mental and sleep disorders, which seem to impair the management and course of the disease. However, there is a lack of accurate results about their prevalence. Consequently, the authors analyze the prevalence of anxiety, depression and/or sleep disorders in DND patients.Areas covered: Among the 206 articles found in the search, 8 studies with data from 5 different countries fulfilled the inclusion criteria. The prevalence of anxiety reported ranged between 7.8%-60.4% and that of depression between 13.6%- 50.6%. The two conditions coexist in 26.4%-30.6% in DND patients. A higher prevalence was found when the information was obtained using scales than when it came from medical records. The prevalence of sleep disorders found ranged from 41.6%-43.8%. However, there is lack of information about and the results are often expressed using the mean scores of the scales.Expert opinion: Although the data in the literature vary, a high prevalence of anxiety, depression and sleep comorbidities exists among patients with DNP. These results reaffirm the need to perform systematic evaluations and to identity their presence using validated instruments to obtain more reliable results.