ABSTRACT
Four new cases of true hermaphroditism in older patients are herein presented. The diagnosis was delayed in all 4 patients and not made in 3 until feminization had occurred. The clinical features, the sex of rearing, gonadal locations, sex chromosomes, treatment and fertility potentials of these patients are discussed. Problems encountered in the management of these older patients underscores the need to exclude at birth bisexuality in any patient with perineal hypospadias and crytorchidism.
Subject(s)
Disorders of Sex Development/diagnosis , Adolescent , Adult , Child Rearing , Child, Preschool , Disorders of Sex Development/psychology , Disorders of Sex Development/surgery , Female , Humans , Karyotyping , MaleSubject(s)
Adenocarcinoma/pathology , Uterine Neoplasms/pathology , Aged , Female , Humans , Middle AgedABSTRACT
Endometrial carcinoma is an uncommon disease in the Nigerian female and its ratio to carcinoma of the cervix could be as low as 1:40, compared with the about 1:2 ratio for the temperate climates. In the 10-year period under review (1973-1982), only 10 cases could be clearly established. Nine tumors were adenocarcinomas, with most of these exhibiting a papillary pattern, while the tenth case was an adenosquamous carcinoma. One of the papillary adenocarcinomas contained clear cells. Most lesions were Grade I or Grade II. The youngest patient was 42 years of age while the oldest patient was aged 78 years (mean age, 58.9 years). A more favorable grade and lesser degree of myometrial invasion characterized the neoplasms in the younger patients.
Subject(s)
Adenocarcinoma/epidemiology , Carcinoma, Squamous Cell/epidemiology , Uterine Neoplasms/epidemiology , Adenocarcinoma/pathology , Adult , Aged , Biopsy , Carcinoma, Squamous Cell/pathology , Female , Humans , Hysterectomy , Middle Aged , Nigeria , Uterine Neoplasms/pathologyABSTRACT
Seventy consecutive patients with carcinoma of the ovary were managed in our unit by laparotomy and extensive debulking procedures over a period of 8 years. Intensive post-operative chemotherapy was given with intravenous cyclophosphamide. The mean follow-up period was 2.6 years. Our results showed that 19 patients with early disease (stages I and II) showed complete remission but seven subsequently died of recurrent disease. The others with more advanced disease showed little response to treatment.
Subject(s)
Carcinoma/drug therapy , Cyclophosphamide/therapeutic use , Ovarian Neoplasms/drug therapy , Adolescent , Adult , Aged , Carcinoma/mortality , Carcinoma/surgery , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Middle Aged , Ovarian Neoplasms/mortality , Ovarian Neoplasms/surgery , Postoperative Care , Prospective Studies , Time FactorsABSTRACT
An unusual type of congenital subgaleal cyst, either dermoid or epidermoid, was found in 21 Nigerian infants. This entity was located in the midline of the scalp, anywhere from above the nasion to the inion, and occupied the subgaleal space. These cysts were noted soon after birth and gradually enlarged. They had no intracranial extension and were easily excised intact. Clinically, radiologically, and histologically they were similar to congenital inclusion dermoid cysts of the anterior fontanel. The histology and some of the peculiarities of these cysts are described. Although most of these cysts occur at the anterior fontanel, they can occur anywhere in the midline, and the subgaleal space of the anterior fontanel is not the exclusive site, as has been claimed by previous authors.
Subject(s)
Dermoid Cyst/congenital , Epidermal Cyst/congenital , Scalp , Skin Neoplasms/congenital , Child, Preschool , Dermoid Cyst/pathology , Epidermal Cyst/pathology , Female , Humans , Infant , Infant, Newborn , Male , Nigeria , Skin Neoplasms/pathologySubject(s)
Subacute Sclerosing Panencephalitis/epidemiology , Child, Preschool , Female , Humans , NigeriaABSTRACT
Two cases of a congenital inclusion dermoid cyst located over the region of the anterior fontanel are described in adult Nigerians, aged 28 and 32 years. In both cases, the cystic lesion was noticed at birth over the anterior fontanel as a small soft lump, and was carried on the head from infancy into adult life. The clinical, radiological, and the operative findings revealed no intracranial extension. The two lesions were histologically verified as dermoid cysts. Surgical excision was curative.
Subject(s)
Dermoid Cyst/congenital , Scalp , Skin Neoplasms/congenital , Adult , Black People , Dermoid Cyst/pathology , Female , Humans , Male , Nigeria , Scalp/pathology , Skin Neoplasms/pathologyABSTRACT
The case of a one-year-old Nigerian with tuberculous panophthalmitis is reported. He presented initially with a localised episceleral mass which was thought to be retinoblastoma due to rapid spread over the fundus induced by subconjunctival depromedrol. Histological examination of the enucleated eye showed that the lesion was due to tuberculosis. The subsequent favorable response of the ocular and radiological chest lesions to antituberculous therapy was quite remarkable. In contrast, there was an adverse response to radiotherapy which had followed enucleation on the strong suspicion of retinoblastoma. Not unnaturally, ocular tuberculosis was not thought of because of the rarity of ocular involvement with this disease. To our knowledge, this is the first case of its type reported from the African Continent.
