Composition of yoga-philosophy based mental traits (Gunas) in major psychiatric disorders: A trans-diagnostic approach.

Yoga philosophy includes the theory of Tri-guna (three mental traits): sattva (signifies a tendency to 'goodness'), rajas (tendency towards 'activity'), and tamas (tendency towards "inertia"). This cross-sectional study aimed to understand the differences in the expression of gunas in patients suffering from major psychiatric disorders (n = 113, 40 females) and age-gender-education-matched healthy controls (HCs; n = 113, 40 females). Patients were diagnosed by a psychiatrist using DSM 5 criteria and suffered from the following disorders: depression (n = 30), schizophrenia (SCZ; n = 28), obsessive-compulsive disorder (OCD; n = 23), anxiety (n = 16), and bipolar affective disorder (BPAD; n = 16). Tri-gunas were assessed using a validated tool (Vedic Personality Inventory) and symptoms were assessed using standard scales as per the diagnosis. Multi-variate analysis of variance (MANOVA) was used to assess the differences in guna scores between HCs and patients, and between patients with different diagnoses. A two-tailed Pearson correlation was performed between the gunas and psychometric scales. Results revealed that HCs had significantly higher sattva traits as compared to patients (except those with OCD). Each psychiatric diagnosis also showed a specific guna configuration: (1) Anxiety disorders and OCD: High sattva-rajas, low tamas; (2) Depression: High sattva-tamas, low rajas; (3) Psychotic disorders (SCZ/BPAD): High tamo-rajas, low sattva. Significant positive correlations were observed between rajas traits and anxiety/OC/positive psychotic symptoms, negative psychotic symptoms and tamas traits, and sattva traits and OC symptoms. This finding has clinical implications, both to develop ways of predicting outcomes of psychiatric disorders, as well as to develop psycho-therapeutic and lifestyle interventions targeting the gunas.

Biobased volatile fatty acids (VFA) production via anaerobic acidogenesis of sugar processing industry effluent.

Rapid industrialization and unscientific disposal of industrial wastewaters have resulted in the pollution of water bodies and deterioration of water quality all over the globe. Valorization of industrial wastewaters will help in reducing the negative impact on the environment and will add value to the waste. The present study targets utilization of sugar processing industrial effluent for bio-based production of Volatile fatty acids (VFA) through anaerobic acidogenesis. Batch studies conducted to determine the VFA production potential of sugar processing industry effluent resulted in the VFA yield of 0.70 g/g COD utilized. Further continuous VFA production system was developed and optimization of Organic loading rate (OLR) (2-22 g COD/L·day) was carried out with constant Hydraulic retention time (HRT) of 1 day. The continuous reactors studies resulted in a maximum VFA yield of 0.72 g/g COD utilized and productivity of 11.04 g COD/L·day at OLR of 14 g COD/L·day and 22 g COD/L·day, respectively. The developed process will provide an environmentally safe and efficient method for the conversion of complex industrial wastes to valuable products such as VFA.

Microbial consortia adaptation to substrate changes in anaerobic digestion.

Renewable natural gas (RNG) produced from anaerobic digestion (AD) of agricultural residues is emerging a serious biofuel alternative. Complex nature of lignocellulosic biomass residues coupled with complex biochemical transformations involving a large spectrum of microbial communities make anaerobic digestion of biomass difficult to understand and control. The present work aims at studying adaptation of microbial consortia in AD to substrates changes and correlating these to biogas generation. The double edged study deals with (a) using a common starting culture inoculum on different fractions of pretreated lignocellulosic biomass (LBM) fractions; and (b) using different starter inocula for gas generation from simple glucose substrate. Taxonomic analysis using 16S amplicon sequencing is shown to highlight changes in microbial community structure and predominance, majorly in hydrolytic bacterial populations. Observed variations in the rate of digestion with different starter inocula could be related to differences in microbial community structure and relative abundance. Results with different treated biomass fractions as substrates indicated that AD performance could be related to abundance of substrate-specific microbial communities. The work is a step to a deeper understanding of AD processes that may lead to better control and operation of AD for super-scale production of RNG from biomass feedstocks.

Development, validation, and feasibility of a generic yoga-based intervention for Generalized Anxiety Disorder.

CONTEXT: Evidence suggests that yoga effectively manages anxiety, but techniques are derived from different yoga schools. This paper describes the development, validation, and feasibility of a generic yoga-based intervention in patients with Generalized Anxiety Disorder (GAD). METHODS: The first part of the study consisted of designing a generic yoga module from the traditional and contemporary yogic literature and inputs from ten experienced yoga practitioners. The content was validated using a case-vignette method from 28 yoga experts. These yoga experts rated the usefulness of the practices on a scale of 1-5 (5-extremely useful). The second part consisted of testing the feasibility of this validated generic yoga intervention in an open-label clinical trial in patients with GAD. Two weeks of ten supervised yoga sessions (SYS) were offered by a trained yoga therapist to the recruited participants and subsequently advised for home practice. A weekly booster SYS was also provided for three months after 10SYS. RESULTS: Yoga experts (n = 28) opined that the yoga intervention would be helpful in patients with GAD with minimal modifications. All experts opined that the module was easy to teach, learn and practice. The final yoga module retained 97.7% (42 out of 43) items of the initial module. In the feasibility study, (n = 20) patients were recruited, and fifteen followed-up after one month. All patients were able to learn and practice the final yoga module within ten sessions without any significant adverse effects. The severity of anxiety reduced substantially after the ten days of SYS and this improvement was sustained for the next 4 weeks. CONCLUSION: The designed generic yoga intervention was validated by yoga experts and found safe and feasible in patients with GAD. Patients obtained significant symptom reductions which need to be confirmed in randomized controlled trials.

Correlation of prakriti diagnosis using AyuSoft prakriti diagnostic tool with clinician rating in patients with psychiatric disorders.

Assessment of individual constitution (prakriti) has been an important basic construct of the Ayurveda system of medicine. The AyuSoft prakriti diagnostic tool has been extensively used in Ayurveda research. However, we could not find any literature regarding reliability of a prakriti diagnostic tool in patients with psychiatric conditions. One hundred and twelve patients (M = 70) suffering from various psychiatric disorders as per ICD-10 criteria were recruited (Depression = 31; Schizophrenia = 30, Anxiety disorders = 27; OCD = 9; BPAD = 15). The AyuSoft tool (developed by C-DAC, Pune, India) was applied to determine their prakriti after obtaining written informed consent. Two Ayurveda physicians independently assessed prakriti of the same patients through clinical examination. Inter-rater reliability was assessed between prakriti scores obtained from AyuSoft and those from the Ayurveda physicians by determining Cohen's Kappa intra-class correlation coefficient (ICC). ICC estimates and their 95% confidence intervals were calculated using SPSS statistical package (version 24.0) based on a mean-rating (k = 2), consistency and two-way mixed-effects model. We observed that there was a significant correlation between dosha scores obtained through AyuSoft and those from the two Ayurveda physicians (for all three doshas: p < 0.01). Inter-rater reliability was moderately strong for vata (ICC = 0.72; Cronbach's alpha = 0.83), good for pitta (ICC = 0.58; Cronbach's alpha = 0.62) and comparatively weak for kaphadosha (ICC = 0.44; Cronbach's alpha = 0.51) respectively. Prakriti diagnosis by AyuSoft was feasible in stabilized psychiatric patients and was found comparable to clinical diagnosis of prakriti by Ayurveda physicians in patients with psychiatric disorders.

Nanostructured WO3/graphene composites for sensing NO x at room temperature.

WO3 has emerged as an outstanding nanomaterial composite for gas sensing applications. In this paper, we report the synthesis of WO3 using two different capping agents, namely, oxalic acid and citric acid, along with cetyltrimethyl ammonium bromide (CTAB). The effect of capping agent on the morphology of WO3 material was investigated and presented. The WO3 materials were characterized using X-ray diffraction analysis (XRD), field emission transmission electron microscopy (FETEM), field emission scanning electron microscopy (FESEM), particle size distribution (PSD) analysis, and UV-visible spectroscopic analysis. WO3 synthesized using oxalic acid exhibited orthorhombic phase with crystallite size of 10 nm, while WO3 obtained using citric acid shows monoclinic phase with crystallite size of 20 nm. WO3 obtained using both capping agents were used to study their gas sensing characteristics, particularly for NO x gas. The cross sensitivity towards interfering gases and organic vapors such as acetone, ethanol, methanol and triethylamine (TEA) was monitored and explained. Furthermore, the composites of WO3 were prepared with graphene by physical mixing to improve the sensitivity, response and recovery time. The composites were tested for gas sensing at room temperature as well as at 50 °C and 100 °C. The results indicated that the citric acid-assisted WO3 material exhibits better response towards NO x sensing when compared with oxalic acid-assisted WO3. Moreover, the sensitivity of the WO3/graphene nanocomposite was better than that of the pristine WO3 material towards NO x gas. The WO3 composite prepared using citric acid as capping agent and graphene exhibits sensing response and recovery time of 29 and 24 s, respectively.

Significance of arterial stiffness in Tridosha analysis: A pilot study.

BACKGROUND: The variations in Tridoshas are the basis for disease diagnosis and treatment in Ayurveda. The doshas are assessed by sensing the pulse manually with fingers which depends on skill of the physician. There is a need to measure doshas using instruments and study them objectively. OBJECTIVE: Arterial stiffness is well established pulse parameter in modern medicine and is closely associated to kathinya in the context of Ayurveda. The aim of our study was to measure arterial stiffness using Nadi Tarangini, a pulse acquisition system, and investigate the significant variations of stiffness across Tridosha locations. MATERIALS AND METHODS: A total of 42 samples of vata, pitta and kapha pulses with proper systolic and diastolic peaks were included in the study. The arterial stiffness parameters namely stiffness index (SI) and reflection index (RI) were considered for the study. The data was analyzed using one-way ANOVA followed by Tamhane's T2 test. The changes in SI and RI between males and females were assessed using independent samples t test. RESULTS: SI at vata (5.669 ± 1.165) was significantly low compared to pitta (8.910 ± 3.509) and kapha (8.021 ± 2.814); RI at vata (0.846 ± 0.071) was significantly low compared to pitta (0.945 ± 0.043) and kapha (0.952 ± 0.033). SI at kapha was significantly low in females compared to males. CONCLUSION: The SI and RI acquired using Nadi Tarangini have shown significant variations across Tridosha locations. The framework developed to measure the arterial stiffness across Tridosha locations can be used for the interventional studies in Ayurveda which in turn can help in disease diagnosis and treatment.