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Genes Chromosomes Cancer ; 44(2): 218-23, 2005 Oct.
Article in English | MEDLINE | ID: mdl-15942942

ABSTRACT

We present an extensive characterization of 10 B-cell lymphomas with a t(9;14)(p13;q32). The presence of the PAX5/IGH gene rearrangement was demonstrated by fluorescence in situ hybridization (FISH) using a validated probe set, whereas complex karyotypic changes were reassessed by multiplex-FISH (M-FISH). Pathologic and clinical review revealed the presence of this rearrangement in 4 histiocyte-rich, T-cell-rich B-cell lymphomas (HRTR-BCLs) and 2 posttransplantation diffuse large B-cell lymphomas (PTLD-DLBCLs). In contrast to initial observations describing this translocation in lymphoplasmacytic lymphoma (LPL) and LPL-derived large B-cell lymphoma, our data showed a wide morphologic and clinical spectrum associated with the PAX5/IGH rearrangement, pointing to an association between this aberration and a subset of de novo DLBCLs presenting with advanced disease and adverse prognosis. In addition, the recurrent incidence of this rearrangement in both HRTR-BCL (4 cases) and PTLD-DLBCL (2 cases) was previously unrecognized and is intriguing.


Subject(s)
DNA-Binding Proteins/genetics , Gene Rearrangement , Immunoglobulin Heavy Chains/genetics , Lymphoma, B-Cell/genetics , Transcription Factors/genetics , Translocation, Genetic , Aged , Aged, 80 and over , Chromosomes, Human, Pair 14 , Chromosomes, Human, Pair 9 , Female , Humans , Karyotyping , Male , Middle Aged , PAX5 Transcription Factor
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