ABSTRACT
Chagas disease and sleeping sickness are neglected tropical diseases closely related to poverty, for which the development of plant-derived treatments has not been a promising prospect. Thus, we systematicaly review the preclinical in vivo evidence on the applicability of plant-based products in the treatment of Trypanosoma cruzi and Trypanosoma brucei infections. Characteristics such as disease models, treatments, toxicological safety and methodological bias were analysed. We recovered 66 full text articles from 16 countries investigating 91 plant species. The disease models and treatments were highly variable. Most studies used native (n = 36, 54·54%) or exotic (n = 30, 45·46%) plants with ethnodirected indication (n = 45, 68·18%) for trypanosomiasis treatment. Complete phytochemical screening and toxicity assays were reported in only 15 (22·73%) and 32 (48·49%) studies, respectively. The currently available preclinical evidence is at high risk of bias. The absence of or incomplete characterization of animal models, treatment protocols, and phytochemical/toxicity analyses impaired the internal validity of the individual studies. Contradictory results of a same plant species compromise the external validity of the evidence, making it difficult determine the effectiveness, safety and biotechnological potential of plant-derived products in the development of new anti-infective agents to treat T. cruzi and T. brucei infections.
Subject(s)
Drug Evaluation, Preclinical , Plant Extracts/pharmacology , Trypanocidal Agents/pharmacology , Trypanosoma brucei brucei/drug effects , Trypanosoma cruzi/drug effects , Animals , Cattle , Chagas Disease/drug therapy , Neglected Diseases/drug therapy , Plant Extracts/therapeutic use , Trypanocidal Agents/therapeutic use , Trypanosomiasis, African/drug therapy , Trypanosomiasis, Bovine/drug therapyABSTRACT
A terapêutica dos pênfigos se fundamenta na corticoterapia sistêmica em doses altas. O uso de imunodepressores é preconizado para reduzir a dose total do coticóide e consequentemente seus efeitos colaterais. Såo descritos os resultados da pulsoterapia com ciclofosfamida em quatro casos de pênfigo foliáceo e um caso de pênfigo vulgar de difícil controle observados no Hospital Universitário Clementino Fraga Filho, no período de 1985 a 1993. Houve remissåo completa e prolongada da doença em um caso de pênfigo foliáceo. A manutençåo de prednisona pode ser reduzida no caso de pênfigo vulgar
