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Cancer ; 98(2): 315-9, 2003 Jul 15.
Article in English | MEDLINE | ID: mdl-12872351

ABSTRACT

BACKGROUND: Invasive infection by Fusarium sp. is associated with high mortality in patients with hematologic cancer. Yet to the authors' knowledge, little is known regarding predictors of adverse outcome. METHODS: The authors conducted a retrospective review of the records of patients with hematologic carcinoma and invasive fusariosis who were treated at one institution in the U.S. and at 11 centers in Brazil. RESULTS: The records of 84 patients were evaluated. Neutropenia was present in 83% and 33 patients had undergone stem cell transplantation. Only 18 patients (21%) were alive 90 days after the diagnosis of fusariosis. Multivariate predictors of poor outcome were persistent neutropenia (hazard ratio [HR] of 5.43; 95% confidence interval [95% CI], 2.64-11.11) and use of corticosteroids (HR of 2.18; 95% CI, 1.98-3.96). The actuarial survival rate of patients without any of these factors was 67% compared with 30% for patients who recovered from neutropenia but were receiving corticosteroids and 4% for patients with persistent neutropenia only. None of the patients with both risk factors survived (P<0.0001). CONCLUSIONS: Measures to reduce the duration of neutropenia, as well as the judicious use of corticosteroids, may reduce the high mortality rate of fusariosis in patients with hematologic cancer.


Subject(s)
Fusarium/isolation & purification , Hematologic Neoplasms/complications , Immunocompromised Host , Mycoses/mortality , Adolescent , Adult , Aged , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Child , Child, Preschool , Female , Hematologic Neoplasms/immunology , Humans , Male , Middle Aged , Mycoses/complications , Mycoses/drug therapy , Prognosis , Retrospective Studies , Stem Cell Transplantation , Survival Analysis
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