Relato de esporotricose felina (Sporothrix schenckii) com transmissäo para o homem: aspectos clínicos, microbiológicos e anatomopatológicos / Cat sporotrichosis (Sporothrix schenckii) with transmission to human being: clinical, microbiological and pathological aspects

Descreve-se um caso de esporotricose em gato, abordando os aspectos clínicos, microbiológicos e anatomopatológicos. Faz-se mençäo à ocorrência da doença no proprietário e no médico veterinário que tiveram contato direto com o animal, ressaltando a importância do gato na transmissäo desta zoonose

Flora fungica do ar e do piso no Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. / Fungic flora in the air and floor at the \"Hospital das Clinicas\" of the Federal University of Minas Gerais, Belo Horizonte, Brazil

Em 11 setores do Hospital das Clinicas da Universidade Federal de Minas Gerais, previamente selecionados quanto as condicoes de contaminacao e controle de acesso ao publico, subdivididos em 49 ambientes de coleta, foram analisados material do ar e do piso, nos horarios da manha e da tarde, com auxilio de placas de Petri com Agar-Sabouraud-Glicose e cotonetes esterilizados para a colheita do material do piso no periodo de 17 de abril a 29 de maio 1980, intercalados de 3 em 3 dias, perfazendo um total de 2940 colheitas. Dentre 9064 colonias isoladas foram identificados 48 generos; 26,90% dos fungos nao apresentaram orgao de frutificacao e foram classificados como Cladosporium (65,03%) Aspergillus (37,08%), Fusarium (22,10%), Penicillium, (19,86%), Aureobasidium (18,40%), Curvularia (16,20%), Nigrospora (15,30%). No ar e no horario da manha, foi observada uma maior quantidade de fungos. Os ambientes considerados contaminados, apresentaram maior concentracao dos mesmos. Entretanto, na cirurgica, onde se deveria esperar uma menor quantidade de esporos fungicos ocorreu o inverso

[Combination of 5-fluorocytosine and amphotericin B in the treatment of chromomycosis]. / Associação de 5-fluorocitosina e anfotericina B no tratamento da cromomicose.

The authors discuss the problem of resistance of chromomycosis to 5-fluorocytosine (5-FC), observed in a previous study in 7 patients initially treated with the drug and subsequently treated with 5-FC associated with other medicaments. All the associations, including that with amphotericin B, failed to overcome resistance. Experiments in mice and "in vitro" show a synergism between 5-FC and amphotericin B against "C. albicans", "C. neoformans" and "Fonsecaeae pedrosoi" already confirmed in human subjects infected with the above mentioned fungi. Resistance to 5-FC seems to be irreversible, as shown in previous experiments. The mechanism of action of the drugs on the fungi is discussed, as well as the fact that amphothericin B prevents the development of resistance to 5-FC. Results obtained with the use of the above association in 5 cases of chromomycosis are presented; all the patients had old and well established lesions, and in three cases these lesions were large and disseminated, conditions probably associated with the development of resistance to 5-FC used alone. The drugs were given in small doses, inferior to those usually recommended. The good therapeutic results seem to confirm the synergism observed in laboratory trials. Four cases were discharged as cured and one abandoned treatment for personal reasons. The association seems to act more rapidly than 5-FC alone. Tolerance was excellent in all cases.