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15.
Pediatr Dermatol ; 39(2): 305-306, 2022 Mar.
Article in English | MEDLINE | ID: mdl-34779035

ABSTRACT

A 14-year-old girl who reported generalized scaling and hyperkeratosis since age 1 year presented with severe pruritus of several months' duration. Scabies mites were detected, and molecular genetic analysis subsequently revealed a rare pathogenic variant in the keratin 2 (KRT2) gene, confirming a diagnosis of superficial epidermolytic ichthyosis. Treatment with oral ivermectin led to complete remission of symptoms. Disorders of keratinization can mimic clinical signs of scabies, leading to a delay in diagnosis.


Subject(s)
Hyperkeratosis, Epidermolytic , Keratosis , Scabies , Adolescent , Animals , Female , Humans , Hyperkeratosis, Epidermolytic/diagnosis , Hyperkeratosis, Epidermolytic/drug therapy , Hyperkeratosis, Epidermolytic/genetics , Infant , Keratin-2/genetics , Sarcoptes scabiei/genetics , Scabies/complications , Scabies/diagnosis , Scabies/drug therapy
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