Estudio inmunologico del paciente neoplasico. / Immunologic study of patients with neoplasms

Los autores efectuaron un estudio inmunologico en 211 pacientes con enfermedades neoplasicas malignas y piensan que el resultado de las pruebas cutaneas y el pronostico sobre la evolucion de los enfermos depende en gran parte de su estado nutricional

Estudio inmunologico del paciente neoplasico. / Immunologic study of patients with neoplasms

Los autores efectuaron un estudio inmunologico en 211 pacientes con enfermedades neoplasicas malignas y piensan que el resultado de las pruebas cutaneas y el pronostico sobre la evolucion de los enfermos depende en gran parte de su estado nutricional

[Prophylaxis of acute gastroduodenal lesions in critically ill patients]. / Profilaxis de las lesiones agudas gastroduodenales en pacientes críticos.

There were 220 patients studied, of which 44 were considered "critical" according to pre-established factors. In all of them, intra-gastrical pH in serious forms was detected, establishing that 45% of the "non-critical" patients had a pH factor less than 4. In these 61 patients and in the 44 "critical" patients a gastric alkalinization was sought, using between 1.2 and 2.4 grams of cimetidina daily, to which alkalines were added when necessary. Nine percent of the critical patients (4 of 44) had H.D.A., while 11 of 33 (33%) of the critically ill from a previous series that had not been treated had pronounced gastro-intestinal bleeding lesions (p less than 0.01.) The potential difference of gastric mucous in critical patients was measured likewise, being significantly less (means = 17.37 +/- 1.13) than in the non-critical patients (means = 30.2 +/- 1.13) (p less than 0.005). The use of cimetidina as an inhibitor of gastric secretion in a dosage of 1.2 grams was effective in 73% of the non-critical patients and in only 29% of the critical patients. Despite an increase in the dosage up to 2.4 grams in 9% of the critical and 22% of the non-critical patients, it was necessary to add alkalines. This lack of response shows a correlation between the amount of risk factors (3 of 10 patients had 3 factors) and the existence of hepatitic insufficiency (5 out of 16 patients and 5 out of 26 of sepsis).

Efectos de los bloqueantes histaminicos H1 y H2 en la ulcera de sujecion en la rata. / Effects of histamine H1 and H2 receptor blockaders in stress ulcer in rats

Se estudio el efecto bloqueante de los receptores H1 y H2, solos o asociados, en ratas sometidas a "stress" por sujecion de 4 horas y frio. Se desprende de los resultados que la cimetidina disminuye significativamente el numero de ulceraciones (p<0.001), no asi los bloqueantes H1, ya sea en forma independiente o asociados a la cimetidina

Utilidad de la povidona iodada en la antisepsia colonica intraoperatoria. / Utility of povidone-iodine in intraoperative colonic antisepsis

La PVP-I ha demostrado, actuando durante solo 10 minutos, notable accion germicida tanto in vitro como in vivo en el colon de perros. In vitro se observo una reduccion bacteriana de 93,34%. En el colon de perros la reduccion alcanzo a 77,28% para los germenes aerobios y a 95% para los anaerobios. En ninguna oportunidad se observaron efectos locales o generales indeseables. Los resultados obtenidos permiten considerar a la PVP-I como muy util para la preparacion inmediata en cirugia colonica, tanto urgente como electiva

Profilaxis de las lesiones agudas gastroduodenales en pacientes críticos. / [Prophylaxis of acute gastroduodenal lesions in critically ill patients]

There were 220 patients studied, of which 44 were considered [quot ]critical[quot ] according to pre-established factors. In all of them, intra-gastrical pH in serious forms was detected, establishing that 45

of the [quot ]non-critical[quot ] patients had a pH factor less than 4. In these 61 patients and in the 44 [quot ]critical[quot ] patients a gastric alkalinization was sought, using between 1.2 and 2.4 grams of cimetidina daily, to which alkalines were added when necessary. Nine percent of the critical patients (4 of 44) had H.D.A., while 11 of 33 (33

) of the critically ill from a previous series that had not been treated had pronounced gastro-intestinal bleeding lesions (p less than 0.01.) The potential difference of gastric mucous in critical patients was measured likewise, being significantly less (means = 17.37 +/- 1.13) than in the non-critical patients (means = 30.2 +/- 1.13) (p less than 0.005). The use of cimetidina as an inhibitor of gastric secretion in a dosage of 1.2 grams was effective in 73

of the non-critical patients and in only 29

of the critical patients. Despite an increase in the dosage up to 2.4 grams in 9

of the critical and 22

of the non-critical patients, it was necessary to add alkalines. This lack of response shows a correlation between the amount of risk factors (3 of 10 patients had 3 factors) and the existence of hepatitic insufficiency (5 out of 16 patients and 5 out of 26 of sepsis).

Efectos de los bloqueantes histaminicos H1 y H2 en la ulcera de sujecion en la rata. / Effects of histamine H1 and H2 receptor blockaders in stress ulcer in rats

Se estudio el efecto bloqueante de los receptores H1 y H2, solos o asociados, en ratas sometidas a "stress" por sujecion de 4 horas y frio. Se desprende de los resultados que la cimetidina disminuye significativamente el numero de ulceraciones (p<0.001), no asi los bloqueantes H1, ya sea en forma independiente o asociados a la cimetidina

Utilidad de la povidona iodada en la antisepsia colonica intraoperatoria. / Utility of povidone-iodine in intraoperative colonic antisepsis

La PVP-I ha demostrado, actuando durante solo 10 minutos, notable accion germicida tanto in vitro como in vivo en el colon de perros. In vitro se observo una reduccion bacteriana de 93,34%. En el colon de perros la reduccion alcanzo a 77,28% para los germenes aerobios y a 95% para los anaerobios. En ninguna oportunidad se observaron efectos locales o generales indeseables. Los resultados obtenidos permiten considerar a la PVP-I como muy util para la preparacion inmediata en cirugia colonica, tanto urgente como electiva

[Experimental studies on pramiverine (author's transl)]. / Experimentelle Untersuchungen mit Pramiverin

A preventive effect of 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine, Sistalgin) was determined on the experimental gastric ulcer in rats. In 14 patients with duodenal ulcers the maximally stimulated gastric secretion was significantly reduced by 50% after pramiverine, which may serve as a reliable criterium for the evaluation of prospective surgical vagotomy. Electromyographic examinations of stomach and duodenum demonstrated the decrease of spontaneous pressure waves in patients and the pressure increases induced by neostigmine. During hypotensive duodenography without the introduction of a probe, pramiverine by a prolonged reduction of motility permits excellent radiological diagnosis in the duodenum and jejunum.