Inclusion team science improves participation of children with disabilities in pediatric obesity programs.

BACKGROUND: Children with disabilities have higher prevalence rates of obesity compared to children without disabilities. Evidence supports the importance of early interventions in preventing pediatric obesity from progressing to adulthood obesity but there are limited opportunities for children with disabilities to participate in these early life programs. OBJECTIVE: The aim of this study was to examine multiple frameworks of disability inclusion that progressively reshaped an existing pediatric obesity intervention program toward improving participation for children with disabilities. METHODS: A qualitative narrative analysis approach involving semi-structured interviews, focus groups and participant observations was used to describe the experiences of eight obese children with disabilities, twelve obese children without disabilities, ten parents and ten volunteer healthcare student trainers who participated in an obesity intervention program, Fit Kids for Life (FKFL). RESULTS: FKFL participants' positive worldviews of disability inclusion, active involvement of parents and family members, diverse team of health professionals and volunteers, and improved health outcomes facilitated children with disabilities' participation in the program. Disability and obesity stigma and lack of local inclusive sites hindered access and participation for children with disabilities. CONCLUSIONS: Results support using inclusion team science to improve participation and outcomes of a pediatric obesity intervention program for children with disabilities.

Atrial fibrillation in healthy adolescents after highly caffeinated beverage consumption: two case reports.

INTRODUCTION: Energy drinks and highly caffeinated drinks comprise some of the fastest growing products of the beverage industry, often targeting teenagers and young adults. Cardiac arrhythmias in children related to high caffeine consumption have not been well described in the literature. This case series describes the possible association between the consumption of highly caffeinated drinks and the subsequent development of atrial fibrillation in the adolescent population. CASE PRESENTATIONS: We report the cases of two Caucasian adolescent boys of 14 and 16 years of age at the time of presentation, each without a significant cardiac history, who presented with palpitations or vague chest discomfort or both after a recent history of excessive caffeine consumption. Both were found to have atrial fibrillation on electrocardiogram; one patient required digoxin to restore a normal sinus rhythm, and the other self-converted after intravenous fluid administration. CONCLUSION: With the increasing popularity of energy drinks in the pediatric and adolescent population, physicians should be aware of the arrhythmogenic potential associated with highly caffeinated beverage consumption. It is important for pediatricians to understand the lack of regulation in the caffeine content and other ingredients of these high-energy beverages and their complications so that parents and children can be educated about the risk of cardiac arrhythmias with excessive energy drink consumption.

Perinatal isolated atrial flutter associated with maternal cocaine and opiate use in a late preterm infant.

Atrial flutter is a serious form of neonatal tachyarrhythmia. Maternal drug use of cocaine and/or opiate is associated with central and autonomic nervous signs in fetuses and newborn infants. The fetal cardiovascular effects of cocaine and opiate exposure are not well characterized. We present the case of isolated atrial flutter in a late preterm infant who has been perinatally exposed to cocaine and opiate.

Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice.

Carney complex (CNC) is a familial multiple neoplasia syndrome characterized by cardiac and extracardiac myxomas in the setting of spotty skin pigmentation and endocrinopathy. We previously identified PRKAR1A (regulatory subunit 1alpha of protein kinase A) mutations in CNC. Mutational analyses of the PRKAR1A gene in 51 unrelated CNC probands now detect mutations in 65%. All mutations, except for one unique missense mutation, lead to PRKAR1A haploinsufficiency. Therefore, we studied the consequences of prkar1a haploinsufficiency in mice. Although we did not observe cardiac myxomas or altered pigmentation in prkar1a(+/-) mice, we did observe some phenotypes similar to CNC, including altered heart rate variability. Moreover, prkar1a(+/-) mice exhibited a marked propensity for extracardiac tumorigenesis. They developed sarcomas and hepatocellular carcinomas. Sarcomas were frequently associated with myxomatous differentiation. Tumors from prkar1a(+/-) mice did not exhibit prkar1a loss of heterozygosity. Thus, we conclude that although PRKAR1A haploinsufficiency does predispose to tumorigenesis, distinct secondary genetic events are required for tumor formation.