Peripheral serotonergic mechanisms in the cardiovascular system of epidermoid lung cancer patients.

The aim of the work was to evaluate the peripheral serotonergic mechanisms in patients with epidermoid lung cancer. The study was performed on lung cancer patients diagnosed on the basis of histopathological findings. The subjects were treated by radiotherapy. Whole blood 5HT in patients with epidermoid lung cancer was increased, whereas uptake of 3H-5HT by platelets was diminished in these patients when compared to control group. Radiotherapy caused a lowering of serotonin in blood to levels observed in healthy subjects. Platelet aggregation induced by ADP was diminished in patients with epidermoid lung cancer, however radiotherapy resulted in an increased sensitivity of platelets to ADP (an enhanced aggregation). On the other hand, serotonergic amplification of ADP-induced platelet aggregation was higher in these patients. This effect was inhibited by radiotherapy. On the basis of our results, we may suggest that peripheral serotonergic mechanisms play an important role in pathogenesis and course of epidermoid lung cancer in humans.

[Stromal sarcoma--a contribution to the theory on the histoclinical aspects of neoplasms]. / Ginekologia i poloznictwo.

The authors report histological and clinical analysis of 7 patients with malignant proliferation of the stromal colls in the endometrium. In 3 patients the histological pattern differed form that in the remaining cases in a greater number of cell divisions and higher grade of cell atypia. Despite this, the clinical pattern was similar in nearly all cases. The reported material cannot support the hypothesis of two forms of the disease: stromal sarcoma and stromatosis. Both these diagnoses carry a poor prognosis.

[Results of treatment of patients with adenoacanthoma and mixed endometrial carcinoma]. / Wyniki leczenia chorych z rozpoznaniem adenoacanthoma i carcinoma mixtum endometrii.

The authors analysed 348 patients with endometrial carcinoma taking into account the diagnoses of adenocarcinoma, adenoacanthoma and mixed carcinoma. In evaluating these patients the degree of histological malignancy, extent of malignant infiltration in the uterus were considered, development of endometrial carcinoma in different phases of life of the women was studied, the hormonal profile and the methods of treatment were analysed. It is stressed that the prognosis of mixed carcinoma is worse than that of adenoacanthoma.