ABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Angioedema/chemically induced , Captopril/adverse effects , Angioedema/diagnosis , Hypertension/drug therapy , Hypertension/complicationsSubject(s)
Blister/etiology , Tuberculin Test/adverse effects , Adult , Blister/pathology , Female , HumansABSTRACT
No disponible
Subject(s)
Female , Adult , Humans , Tuberculosis/diagnosis , Tuberculin Test/adverse effects , Skin Diseases, Vesiculobullous/chemically inducedABSTRACT
BACKGROUND: Plasma cell balanitis or balanitis of Zoon (BZ) is a frequent diagnosis in mature men and lesions are generally localized on the glans but may involve the prepuce; its aetiology remains unknown. OBJECTIVES: To present our experience with tacrolimus 0.1% ointment in the treatment of two patients with BZ refractive to other topical treatments. PATIENTS AND METHODS: Two uncircumcised mature caucasian males were seen, both presenting with BZ; topical tacrolimus 0.1% ointment twice daily was prescribed in each case. RESULTS: Marked improvement of the lesions in both patients has been observed, with follow-up of 1 year and 10 months, respectively. CONCLUSIONS: Topical tacrolimus 0.1% ointment is an effective and safe treatment for BZ.
Subject(s)
Balanitis/drug therapy , Immunosuppressive Agents/therapeutic use , Tacrolimus/therapeutic use , Aged , Balanitis/pathology , Follow-Up Studies , Humans , Male , Ointments , Plasma Cells/pathologyABSTRACT
BACKGROUND: Becker's naevus (BN) may represent a distressing cosmetic handicap and a challenging issue regarding treatment. OBJECTIVES: To compare clinical and histopathological findings of patients with BN treated with two different lasers: an erbium:yttrium-aluminium-garnet (Er:YAG) system vs. a neodymium:YAG (Nd:YAG) laser. PATIENTS AND METHODS: In this prospective and comparative study we present the clinical and histopathological evolution during a 2-year follow-up of 22 patients with BN treated with only one pass of the Er:YAG laser (n = 11) or three treatment sessions with the Q-switched Nd:YAG system (n = 11). RESULTS: Clinical evaluation 2 years after treatment with the Er:YAG laser showed complete clearance (100%) in 54% of the patients (n = 6) and clearance of > 50% in 100% of the subjects. In relation to Nd:YAG laser treatments our results echo those of other authors. Numerous sessions are necessary to get an acceptable clinical clearance rate. Only one patient showed marked clearance (51-99%) after three treatment sessions. Moderate (26-50%) and mild (1-25%) clearance was observed in 45.5% (n = 5) and 27.3% (n = 3) of the patients. CONCLUSIONS: Both Er:YAG and Nd:YAG are safe tools to treat BN. However, in terms of pigment removal, one pass with Er:YAG is a superior technique to three treatment sessions with the Nd:YAG.
Subject(s)
Laser Coagulation/methods , Laser Therapy , Nevus, Pigmented/surgery , Skin Neoplasms/surgery , Adult , Female , Follow-Up Studies , Humans , Laser Coagulation/adverse effects , Lasers/adverse effects , Male , Nevus, Pigmented/pathology , Nevus, Pigmented/radiotherapy , Prospective Studies , Skin Neoplasms/pathology , Skin Neoplasms/radiotherapy , Treatment OutcomeABSTRACT
BACKGROUND: Histologic findings are not echoed in the visible effect in the epidermis after skin rejuvenation. SUBJECTS AND METHODS: Ten women (Group A) received five treatment sessions with a 595-nm pulsed dye laser immediately followed by a 1450-nm diode laser. Two other demographically similar groups of 10 patients each, Groups B and C, were treated with the 595-nm pulsed dye laser or the 1450-nm diode laser alone, respectively. RESULTS: Good dermal collagen remodeling was observed in Group A. Overall better and faster results were seen in Group A. The 6-month clinical outcome was best in Group A followed by Group C and Group B. CONCLUSIONS: Wavelengths of 595 plus 1450 nm for skin rejuvenation produced good results with much higher patient satisfaction than those obtained with the 595- or 1450-nm wavelengths alone.
Subject(s)
Face , Laser Therapy , Low-Level Light Therapy , Rejuvenation , Skin Aging/radiation effects , Adult , Female , Humans , Middle Aged , Treatment OutcomeABSTRACT
BACKGROUND: Radiotherapy as a first-choice treatment for in situ extramammary Paget disease has been successfully used. OBJECTIVES: To review the most relevant aspects of radiotherapy as first-choice treatment in selected cases of in situ extramammary Paget disease of the vulva. PATIENTS AND METHODS: Two Caucasian females aged 76 and 92 years with in situ extramammary Paget disease localized in the genital region were treated by means of ortovoltage X-rays: 100 kV, 8 mA, 1.7 mm Al filter, field size of 12-cm cone, and source skin distance of 30 cm. Both patients received 40 Gy, 200 cGy per fraction, five fractions per week. RESULTS: Complete regression of in situ extramammary Paget disease was observed in both patients after radical radiation therapy and neither local recurrences nor internal malignancies were detected. CONCLUSIONS: Radiotherapy is a curative treatment in selected cases of in situ extramammary Paget disease affecting the vulva.
Subject(s)
Paget Disease, Extramammary/radiotherapy , Vulvar Neoplasms/radiotherapy , Aged , Aged, 80 and over , Female , Humans , Paget Disease, Extramammary/pathology , Radiation Dosage , Vulvar Neoplasms/pathologyABSTRACT
El desarrollo tecnológico del último siglo trajo consigo la incorporación de adelantos en los métodos diagnósticos no invasivos en la medicina, así como en la dermatología. Hoy día el dermatólogo cuenta con técnicas precisas, como la ecografía, la resonancia magnética (RM) o la tomografía computarizada (TC), que permiten obtener información de manera rápida sobre enfermedades de la piel y anexos. En esta primera parte revisaremos aspectos de técnicas como la dermatoscopia, la perfilometría o el ultrasonido de alta resolución, así como las técnicas que se emplean para valorar el pH, la hidratación, la flora y la función de barrera de la piel (AU)
Subject(s)
Humans , Diagnostic Techniques and Procedures , Skin Diseases/diagnosisSubject(s)
Alopecia/surgery , Hair/transplantation , Adult , Alopecia/drug therapy , Alopecia/pathology , Cicatrix/pathology , Female , HumansABSTRACT
BACKGROUND AND OBJECTIVE: Few reports about melanocytic lesions treatment by means of noncoherent-intense-pulsed light (NCIPL) have been published. Here we evaluate the clinical results of a relapsing hairy intradermal melanocytic nevus treated with a noncoherent-intense-pulsed light source. STUDY DESIGN/MATERIALS AND METHODS: A facial repigmented hairy intradermal melanocytic nevus that relapsed after shave excision, received four treatment sessions of a noncoherent-intense-pulsed light source (EpiLight, ESC Medical Systems Ltd, Israel) with the following parameters: 755 nm, a fluence energy of 40-42.5 J/cm(2), triple mode, a pulse width of 3.8 ms, and a delay of 20 ms, at 4-week intervals. RESULTS: Complete pigment clearance and hair removal was obtained. We have neither observed repigmentation nor hair regrowth after a 6 month-follow-up. No side effects were documented. CONCLUSIONS: Noncoherent-intense-pulse light is an effective treatment for hairy-pigmented melanocytic nevus.
Subject(s)
Neoplasm Recurrence, Local/therapy , Nevus, Pigmented/surgery , Nevus, Pigmented/therapy , Phototherapy , Adult , Female , HumansABSTRACT
BACKGROUND: Widespread unilateral nevus spilus causes important cosmetic and psychological disturbances, and only a few therapeutic options can guarantee good functional and cosmetic results. OBJECTIVE: To evaluate the clinical response of a patient with widespread segmental nevus spilus to Q-switched (QS) alexandrite laser. METHODS: The treatment was QS alexandrite laser (755 nm, 100 nsec) with a mean fluence of 7.28 +/- 0.37 J/cm2 using a single-impact technique at 10 +/- 8.47-week intervals. RESULTS: Fifty percent clearance of the facial portion of the lesion was observed after 16 treatment sessions with QS alexandrite laser. CONCLUSION: QS alexandrite laser is suitable for removal of widespread segmental nevus spilus.
Subject(s)
Facial Neoplasms/therapy , Laser Therapy , Nevus, Pigmented/therapy , Skin Neoplasms/therapy , Adolescent , Biopsy , Facial Neoplasms/pathology , Follow-Up Studies , Humans , Male , Nevus, Pigmented/pathology , Retreatment , Skin/pathology , Skin Neoplasms/pathologyABSTRACT
BACKGROUND: Radiotherapy as a first-choice treatment for extramammary Paget's (EMP) disease in situ has been seldom used. OBJECTIVE: To review the most relevant aspects of radiotherapy as first-choice treatment in selected cases of anogenital EMP disease in situ. METHODS: Two men with an age range of 71-79 years (mean age 75 +/- 5.6 years) with EMP disease in situ localized in the genital region were treated by means of X-rays of 100 kV, 440 cGy/day, 3 days a week over 3 weeks until a total dose of 3960 cGy was completed. RESULTS: Complete regression of EMP disease in situ was observed in both patients after radical radiation therapy and neither local recurrences nor internal malignancies have been documented. CONCLUSION: Radiotherapy is a curative treatment in selected cases of EMP disease in situ affecting large areas of the anogenital region.
Subject(s)
Paget Disease, Extramammary/radiotherapy , Skin Neoplasms/radiotherapy , Aged , Genitalia, Male , Humans , Male , Paget Disease, Extramammary/pathology , Skin Neoplasms/pathology , Treatment OutcomeABSTRACT
BACKGROUND AND OBJECTIVE: Q-switched laser systems have been shown to be useful for removal of nevus of Ota, a pigmented lesion on the face. The purpose of this study was to evaluate the efficacy of Q-switched alexandrite laser in the treatment of nevus of Ota in 13 patients. STUDY DESIGN/MATERIALS AND METHODS: A spot test was made at 6.0, 7.0, and 8.0 J/cm(2) energy fluence, and the best energy fluence was selected after a 2-month postoperative evaluation. Q-switched alexandrite laser with a mean fluence of 7.290.46 J/cm(2) was used at 8-week intervals. Total treatment ranged from 1 to 15 sessions (mean 7.1 +/- 5.1 sessions). The single shot technique was used. RESULTS: More than 75% lightening was achieved in seven patients, between 51% and 75% in three, less than 50% in one, and less than 25% in one. In two patients with excellent clearance, a very light gray macula in the lower eyelid persisted after 8 and 14 treatment sessions, respectively. Mild transient hypopigmentation that subsided spontaneously after 2 months was observed in one patient. No repigmentation was seen. CONCLUSIONS: The Q-switched alexandrite laser seems to be an effective and safe modality for the treatment of nevus of Ota.
Subject(s)
Facial Neoplasms/surgery , Laser Therapy/methods , Nevus of Ota/surgery , Skin Neoplasms/surgery , Adolescent , Adult , Child , Female , Humans , Middle Aged , Treatment OutcomeABSTRACT
BACKGROUND: Few reports about melanocytic lesion treatment using intense pulsed light have been published. OBJECTIVES: To evaluate the clinical results of diverse melanocytic lesions after treatment with an intense pulsed light source. METHODS: Superficial and deep melanocytic lesions were treated by an intense pulsed light source with the following parameters: filters of 590, 615, and 755 nm, a fluence energy of 34-38 J/cm2, double mode, a pulse width of 3.8-4.5 msec, and a delay of 20 msec, at 4- to 8-week intervals. Two treatment sessions were applied to superficial lesions, while deep ones received four. RESULTS: A clearance of 76-100% (excellent) was obtained for superficial lesions such as ephelides, epidermal melasma, and café au lait macules. Nevus spilus showed good clinical clearance (51-75%); however, deep lesions such as nevus of Becker, epidermal nevus, and mixed melasma showed an average clearance of less than 25%. Postinflammatory hyperpigmentation was observed in melasma. CONCLUSION: Intense pulsed light is an effective treatment for superficial melanocytic lesions; however, those with a deep component improve only if repetitive treatment sessions are applied.
Subject(s)
Hyperpigmentation/therapy , Phototherapy/methods , Adolescent , Adult , Female , Humans , Hyperpigmentation/pathology , Male , Middle AgedABSTRACT
BACKGROUND AND OBJECTIVE: Different treatment modalities have been advocated for necrobiosis lipoidica diabeticorum but clinical response is unpredictable. The purpose of this study was to evaluate the usefulness of pulsed dye laser (Candela SPTL, Irvine, MA, USA) in the treatment of an area of necrobiosis lipoidica of 4 cm in diameter on the anterior aspect of the leg in a non-diabetic patient. MATERIALS AND METHODS: A spot test was made at 6.0, 6.5 and 7.0 J/cm(2) energy fluences and the best energy fluence was selected after a 2-month postoperative evaluation. The patient received three treatment sessions with a fluence of 6.5 J/cm(2), 585-nm wavelength, 5-mm spot size, and 450 micro(s) pulse duration at 8-week intervals. The patient was given routine skin care advice with emollient cream and sunscreen (SPF 15) until the following session. RESULTS: Overall cosmetic improvement was achieved, with a decrease of erythema and telangiectasis, and stabilization in terms of progression (size) in the left half of the lesion, with no modification of atrophy or pigmentary changes. The right upper quadrant of the lesion showed an erythematous peripheral halo with minimal reduction in the erythema and telangiectasia, and discrete size increase. CONCLUSION: Pulsed dye laser may be a useful treatment for improving the telangiectasia and erythematous component of necrobiosis lipoidica.
