ABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Pyoderma Gangrenosum/diagnosis , Inflammatory Bowel Diseases/diagnosis , Gastrointestinal Hemorrhage/etiology , Skin Ulcer/etiology , Fever/etiologyABSTRACT
No disponible
Subject(s)
Female , Adult , Humans , Foot Dermatoses/diagnosis , Foot Dermatoses/etiology , Acacia/adverse effects , Mycetoma/diagnosis , Mycetoma/etiology , Foot Dermatoses/pathologyABSTRACT
Malignant or noduloulcerative syphilis is an infrequent variant of secondary syphilis which appears in HIV+ patients. It is associated with fever, general malaise and skin lesions in the form of pustules or ulcerative scabs. Histology studies on the lesions show a perivascular infiltration of plasma cells and a formation of granuloma of giant and epitheloid cells. Most patients test positive for syphilis. We discuss the case of a 37-yar-old man who attended our service complaining of fever and scabby nodular lesions all over his skin. Blood testing confirmed that he had syphilis and HIV. The patient responded rapidly to penicillin treatment, with remittance of his fever. The skin lesions disappeared after 8 weeks. The rareness of malignant syphilis and its unusual clinical manifestation is a challenge to medical personnel. This diagnosis ought to be considered in HIV+ patients with fever and ulcerative skin lesions. Penicillin is the treatment of choice.
Subject(s)
HIV Infections/complications , Syphilis/diagnosis , Syphilis/etiology , Adult , Humans , MaleABSTRACT
La sífilis maligna o nódulo-ulcerativa es una forma clínica infrecuente de la sífilis secundaria que aparece en pacientes infectados por el virus de la inmunodeficiencia humana (VIH). Se presenta con fiebre, malestar general y lesiones cutáneas en forma de pústulas o costras ulceradas. El estudio histológico de las lesiones muestra un infiltrado perivascular de células plasmáticas y formación de granulomas de células gigantes y epitelioides. La serología luética es positiva en la mayoría de los pacientes. Presentamos el caso de un varón de 37 años que acude a nuestro Servicio por fiebre y lesiones nódulo-costrosas por todo el tegumento. La sospecha de lúes se apoyó en la histología y se confirmó por la serología positiva. Se solicitó serología VIH que también fue positiva. La respuesta al tratamiento con penicilina fue rápida, con desaparición de la fiebre. Las lesiones cutáneas resolvieron a las 8 semanas. La rareza de la sífilis maligna y su inusual forma clínica de manifestarse es un reto para el clínico. Es un diagnóstico que debe ser considerado en pacientes infectadoss por el VIH con fiebre y lesiones cutáneas ulceradas. El tratamiento de elección es la penicilina
Malignant or noduloulcerative syphilis is an infrequent variant of secondary syphilis which appears in HIV+ patients. It is associated with fever, general malaise and skin lesions in the form of pustules or ulcerative scabs. Histology studies on the lesions show a perivascular infiltration of plasma cells and a formation of granuloma of giant and epitheloid cells. Most patients test positive for syphilis. We discuss the case of a 37-yar-old man who attended our service complaining of fever and scabby nodular lesions all over his skin. Blood testing confirmed that he had syphilis and HIV. The patient responded rapidly to penicillin treatment, with remittance of his fever. The skin lesions disappeared after 8 weeks. The rareness of malignant syphilis and its unusual clinical manifestation is a challenge to medical personnel. This diagnosis ought to be considered in HIV+ patients with fever and ulcerative skin lesions. Penicillin is the treatment of choice
Subject(s)
Male , Adult , Humans , Syphilis/pathology , HIV Infections/complications , AIDS-Related Opportunistic Infections/diagnosis , Penicillins/therapeutic useABSTRACT
No disponible
Subject(s)
Aged, 80 and over , Aged , Female , Humans , Fatal Outcome , Nutrition Disorders , Pellagra , Confusion , Diagnosis, DifferentialABSTRACT
La piodermia gangrenosa y la policondritis recidivante son enfermedades infrecuentes de etiología desconocida a menudo asociadas con procesos autoinmunes. Presentamos el caso de una mujer de 28 años con piodermia gangrenosa y policondritis recidivante que fue tratada con ciclosporina A, mejorando gradualmente los síntomas de ambas entidades. Hasta donde tenemos conocimiento éste es el tercer caso publicado de esta asociación (AU)
Subject(s)
Adult , Female , Humans , Pyoderma Gangrenosum/complications , Pyoderma Gangrenosum/diagnosis , Pyoderma Gangrenosum/therapy , Polychondritis, Relapsing/complications , Polychondritis, Relapsing/diagnosis , Polychondritis, Relapsing/therapy , Cyclosporine/administration & dosage , Cyclosporine/therapeutic use , Biopsy/methods , C-Reactive Protein , Thorax , Necrosis , Diabetic Foot , Foot Ulcer/complications , Foot Ulcer/pathology , Arthritis, Rheumatoid/complications , Skin Diseases/complications , Skin Diseases/diagnosis , Skin Diseases/therapySubject(s)
Hemangiosarcoma/pathology , Skin Neoplasms/pathology , Aged , Female , Humans , Male , Middle AgedABSTRACT
We present herein our experience concerning the use of etretinate and methotrexate as concurrent therapies in three patients with severe psoriasis. On this regimen, rapid clearing of the psoriatic lesions has been achieved in all patients. The efficacy, safety, indications and dosage schedules for this combination therapy are discussed. No significant side effects have been observed in our patients. However, caution must be exercised in the use of this experimental combination regimen, which should only be used in severe psoriasis.
