Protein polymorphism in three South Amerindian populations.

Electrophoretic polymorphism at loci coding for blood red cells and plasma proteins was analysed in three native populations of South America: Mataco and Macá (from the Gran Chaco), and Guayaki (from the Paraguayan forest). Mean heterozygosity per locus varied from 0.024 and 0.073, the Macá being the most polymorphic population, probably reflecting admixture with the caucasoid population of Asuncion city. Although the external phenotype, blood group frequencies and ethno-linguistic affiliation of the Guayaki clearly differ from those of the Chaco tribes, Nei's genetic distances were very low and almost equidistant among the three populations. Heterogeneity of F(ST) values among polymorphic loci would suggest the action of natural selection.

[Eye involvement in Chagas disease (American trypanosomiasis). 1996/1997 studies in Paraguay]. / Augenbeteiligung bei Chagas-Krankheit (Amerikanische Trypanosomiasis). Untersuchungen in Paraguay 1996/1997.

BACKGROUND: Last year's pilot study, which examined for the first time a representative group of patients with Chagas disease, showed that in this parasitosis changes in the ocular fundus can be expected in the form of defects of the retinal pigment epithelium. Examination of more patients in this study should give further information about the character and extent of the alterations found. MATERIALS AND METHODS: After serological confirmation of the disease, we performed an ophthalmological examination of the anterior and posterior segments. RESULTS: In 21 out of 23 patients the fundus was unobtrusive; 1 patient showed fibrae medullares and 1 patient clear pigment dispersion on the posterior pole. Together with the pilot study, a total of 102 chagasic patients were examined. In 8 patients (7.8%) defects of the retinal pigment epithelium were found, which did not cause any significant loss of vision. CONCLUSIONS: We presume that the described defects are a matter of rare and harmless postinflammatory or immunological changes in the American type of trypanosomiasis.

Prevalence of diabetes mellitus and associated cardiovascular risk factors in an adult urban population in Paraguay.

A cross-sectional study was conducted on a 20-74-year-old population in an urban white-Hispanic population in Paraguay to determine the prevalence of diabetes mellitus (DM), impaired glucose tolerance (IGT), and associated cardiovascular disease (CVD) risk factors. In total 1606 subjects completed the study (response rate 80.3%; 1094 women, 512 men). The overall prevalences were: DM 6.5%, IGT 11.3%, hypertension 17.1%, and obesity 31.6% with more obesity in women (35.7% vs 22.8%, p < 0.05). Age-standardized prevalences were: DM 6.5%, IGT 13.5% in females and DM 5.5%, IGT 7.2% in males. DM and IGT subjects had two or more CV risk factors significantly more often than the normal population. In conclusion, DM, IGT, hypertension, and obesity are common in this South American Hispanic urban population, particularly in women. Public health measures, such as lifestyle education, are required to decrease these noncommunicable diseases.

[Intraocular involvement of Chagas disease (American trypanosomiasis). Studies in Paraguay/South America]. / Beteiligung der Chagas-Krankheit (Amerikanische Trypanosomiasis) am inneren Auge. Untersuchungen in Paraguay/Südamerika.

BACKGROUND: In Central and South America, Chagas' disease is of great epidemiologic importance. The epidemiologic agent is represented by Trypanosoma cruzi, a monocellular parasite, instrumental in human infection is the presence of vectors, which are various species of hematophagous bugs. The eye is one of the most important entrance sites of the parasite, and relatively little information about the relationship between Chagas' disease and eye complications is available. PATIENTS AND METHODS: We examined 79 chagasic patients in order to detect changes in the retina. As a control group, we examined 48 patients with negative serology within the same age range and from the same regions. For every patient we completed a routine ophthalmologic examination, with inspection of the retina using direct and indirect ophthalmoscopy. RESULTS: In most of the chagasic patients, the ocular fundus was unobtrusive; in only 6 out of 79 cases (7.6%) we did observe small parafoveolar retinal pigment epithelium defects and in 1 case (1.3%) distinct pigment epithelium atrophy of the posterior pole. No comparable findings were observed in the control group. CONCLUSION: Compared with the examination results of the control group, in the patients with intermediate and chronic Chagas' disease we observed an accumulation of retinal pigment epithelium defects, which, however, did not cause a significant loss of vision.

Plants used as means of abortion, contraception, sterilization and fecundation by Paraguayan indigenous people.

PIP: Plants used by indigenous Paraguayan groups for contraception, abortion, sterilization, and fertility are identified by species and listed by indigenous group, linguistic family, and self-given name. The preparation and manner of administration of each plant is briefly described.^ieng

Cytological effects of some medicinal plants used in the control of fertility.

PIP: The effects of infusions of Aristolochia triangularis and Stevia rebaudiana, plants used by rural and indigenous populations of Paraguay for the control of fertility, on the cell cycle of Allium cepa L. meristems were investigated. Mitotic phase indices after 2, 4, 6, and 24 hours of treatment with infusions of A. triangularis showed a typical c-mitotic action, and recovery was normal in all cases. In contrast, S. rebaudiana had no specific toxicological effects on the cell cycle, which suggests that its contraceptive properties may not be connected with chromosome cycle.^ieng