Subject(s)
Acetylcysteine/therapeutic use , Expectorants/therapeutic use , Oxidative Stress/physiology , Pulmonary Disease, Chronic Obstructive/drug therapy , Animals , Free Radical Scavengers/therapeutic use , Humans , Models, Animal , Pulmonary Disease, Chronic Obstructive/etiology , Rats , Smoking/adverse effectsABSTRACT
No disponible
Subject(s)
Rats , Animals , Humans , Tobacco Use Disorder , Free Radical Scavengers , Oxidative Stress , Pulmonary Disease, Chronic Obstructive , Models, Animal , Acetylcysteine , ExpectorantsSubject(s)
Lung/abnormalities , Adult , Congenital Abnormalities/diagnosis , Female , Humans , Pulmonary Atelectasis/etiologyABSTRACT
Pseudo chylothorax is a rare form of pleural effusion. It appears in long-term effusions, generally those lasting more than 5 years. The most frequent causes are tuberculous pleuritis and pleurel effusion secondary to rheumatoid arthritis. We describe a patient with pleural effusion lasting over 20 years who developed pseudo chylothorax and Mycobacterium tuberculosis in fluid culture.
Subject(s)
Chylothorax/etiology , Mycobacterium tuberculosis/isolation & purification , Pleural Effusion/microbiology , Tuberculosis, Pleural/complications , Aged , Humans , Male , Pleural Effusion/diagnostic imaging , Radiography , Time FactorsABSTRACT
We report the features of 51 cases of hospital-acquired Legionella pneumophila pneumonia (HLP), diagnosed in our hospital during a period of about 5 years. Mean age was 64.6 years, and the male:female ratio 1.6. 29% of HLP involved patients who were not admitted to the hospital at the time of diagnosis. The monthly distribution showed a maximal incidence in July and August. Only 6% of cases involved patients without underlying diseases. The most common underlying diseases were chronic obstructive lung disease (COLD) (37%), heart disease (29%) and immunosuppressant therapy (29%). 21% of the patients with renal transplant had HLP. The only constant clinical feature was fever of 37.8 degrees C or higher. During the first 24-48 hours of illness, respiratory symptoms were not present in 41% of cases, and thoracic abnormalities in the physical examination were not present in 31%. The laboratory abnormalities were nonspecific and with incidence rates lower than 50%. In 41% of patients there was hypoxemia (60 mmHg or lower) with FiO2 of 0.21. The most common radiological finding was the initial unilateral and unilobar involvement. Pleural effusion and cavitation developed in 20% and 4%, respectively. Overall mortality rate was 12%. In the 43 patients treated early with intravenous erythromycin, mortality rate was 7%. We think that the relatively low incidence of severe underlying immunosuppression and the inclusion of hospital-acquired pneumonia in our institution influenced the low mortality rate of the present study, in contrast with other series of hospital-acquired legionellosis.
Subject(s)
Cross Infection/pathology , Legionnaires' Disease/pathology , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle AgedSubject(s)
Amiodarone/adverse effects , Benzofurans/adverse effects , Pulmonary Fibrosis/chemically induced , Aged , Humans , MaleSubject(s)
Immunologic Deficiency Syndromes/complications , Pneumonia, Pneumocystis/complications , Aged , Drug Combinations/therapeutic use , Humans , Hypoglycemia/chemically induced , Male , Pentamidine/adverse effects , Pentamidine/therapeutic use , Pneumonia, Pneumocystis/drug therapy , Sulfamethoxazole/therapeutic use , Trimethoprim/therapeutic use , Trimethoprim, Sulfamethoxazole Drug CombinationSubject(s)
Mediastinal Diseases/diagnosis , Mediastinal Neoplasms/diagnosis , Adolescent , Adult , Aged , Child , Cysts/diagnosis , Female , Goiter, Substernal/diagnosis , Humans , Lymphoma/diagnosis , Male , Middle Aged , Neoplasms, Germ Cell and Embryonal/diagnosis , Neoplasms, Nerve Tissue/diagnosis , Retrospective Studies , Thymoma/diagnosisSubject(s)
Cholesterol/analysis , Pneumonia/pathology , Cholesterol Esters/analysis , Female , Humans , Lung/pathology , Macrophages/analysis , Middle AgedSubject(s)
Granuloma/complications , Lung Diseases/complications , Lymphomatoid Granulomatosis/complications , Vasculitis/etiology , Adolescent , Adult , Child , Diagnosis, Differential , Female , Granuloma/diagnosis , Granulomatosis with Polyangiitis/diagnosis , Humans , Lung Diseases/diagnosis , Lymphomatoid Granulomatosis/diagnosis , Male , Middle AgedSubject(s)
Tuberculosis, Miliary/diagnosis , Adolescent , Adult , Age Factors , Aged , Child , Child, Preschool , Disease Susceptibility , Female , Humans , Infant , Male , Middle Aged , Spain , Tuberculosis, Miliary/epidemiology , Tuberculosis, Miliary/pathologyABSTRACT
Eight cases of chronic eosinophilic pneumonia (CEP) diagnosed between January 1977 and December 1979 are described. Clinical manifestations included toxic syndrome, cough and fever, lasting from 1 to 15 months. Chest x-ray revealed peripheric bilateral infiltrates, with the exception of one case. In two patients there was no peripheral eosinophilia and five received antituberculous drugs at some point during the illness. In all cases tests for fungi and parasites were negative. In only two patients was an increase in IgE found. Hystological study confirmed CEP in 7 patients through either trans-bronchial biopsy or minimal thoracotomy. Treatment with corticosteroids was dramatically effective in all patients; both clinically and radiologically. In two cases which were asymptomatic, decreased carbon monoxide diffusing capacity persisted six months later. One hundred fifteen cases of CEP published since Carrington et al. first described CEP as a separate entity of the pulmonary infiltrates with eosinophilia syndrome are reviewed.
Subject(s)
Pulmonary Eosinophilia/diagnostic imaging , Adrenal Cortex Hormones/therapeutic use , Adult , Aged , Biopsy , Chronic Disease , Female , Humans , Lung/pathology , Male , Middle Aged , Pulmonary Eosinophilia/drug therapy , Pulmonary Eosinophilia/pathology , Pulmonary Eosinophilia/physiopathology , Radiography , Respiratory Function TestsABSTRACT
From a series of 110 patients with sarcoidosis seen at our hospital from October 1971 to September 1979, five cases were found with histologically proven pleural sarcoidosis, an incidence of 4.6%. Pleural involvement was not described in the surgical or autopsy protocols. Infiltration by sarcoid granulomas was found in the visceral and/or parietal layers in five cases of seven in whom pleural tissue was available for examination. The layer affected depended directly on the available sample. Only one patient had pleural effusion, which was an exudate with a high lymphocyte count; the case corresponded to a stage II sarcoidosis. The number of histologically proven cases of pleural sarcoidosis reported in the medical literature is very small, only 52 cass, including our own. In conclusion, it appears that the frequency of pleural sarcoidosis is falsely low, and that the availability of pleural tissue in patients with sarcoidosis undergoing thoracotomy might rise the figures heretofore encountered.
