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Org Biomol Chem
; 14(21): 4943-6, 2016 Jun 07.
Article
in English
| MEDLINE
| ID: mdl-27171614
ABSTRACT
An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented. Key steps of the strategy include tandem Petasis and Diels-Alder reactions, and divergent complexity-generating cyclization cascades from a key dialdehyde intermediate. The methodology is validated through the synthesis of a representative compound set, which has been used in the production of 1617 molecules for the European Lead Factory.