ABSTRACT
OBJECTIVE: We present a patient with pancreatic cancer who developed weakness, acute renal failure and significantly raised creatine kinase levels post-ERCP and who was assessed as having contrast-induced rhabdomyolysis. RESULTS: The patient underwent haemofiltration and ultimately succumbed to his condition. CONCLUSION: Rhabdomyolysis is a potentially life-threatening condition which occurs because of damage to skeletal muscle, with release of myoglobin and electrolytes into the circulation. The mortality rate is 59% in severe cases, despite appropriate treatment. LEARNING POINTS: Iodine-based contrast can cause rhabdomyolysis by reducing blood flow to the muscle.Renal replacement therapy does not improve the mortality rate of rhabdomyolysis.<10% of patients present with the classic triad of myalgia, muscle weakness and tea-coloured urine; creatine kinase levels greater than 5 times the upper limit of normal are the gold standard for diagnosing rhabdomyolysis that is not related to statin use.
ABSTRACT
The aim of this case report and literature review is to explore the rarely highlighted co-occurrence of malignant melanoma and Parkinson's disease (PD) and to describe the devastating effects on those affected. We present a case of acute confusion and worsening shuffling gait in a patient with Parkinson's disease who eventually succumbed to metastatic malignant melanoma, secondary to a primary malignant melanoma on the back that was treated 6 years earlier. More research is needed to better characterize the associations between these two conditions, and to evaluate the effectiveness of prevention strategies such as melanoma screening for adults with PD. LEARNING POINTS: The underlying mechanism for the co-occurrence of Parkinson's disease (PD) and malignant melanoma remains unclear but available evidence suggests genetic associations and environmental factors as potential causes.Patients with PD may require closer dermatological surveillance, particularly those with other risk factors for melanoma such as prolonged sun exposure.More research is needed to better characterize the associations between PD and skin cancers, and to evaluate the effectiveness of prevention strategies such as melanoma screening for adults with PD.
