Subject(s)
Humans , Female , Pregnancy , Pregnancy Complications/diagnosis , Pregnancy Complications/therapy , Algorithms , Diabetes Mellitus, Type 2/classification , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 1/classification , Diabetes Mellitus, Type 1/complications , Glycated Hemoglobin/analysis , Arterial Pressure/physiology , Diabetic Neuropathies/complications , Diabetic Neuropathies/diagnosis , Diabetic Neuropathies/therapyABSTRACT
Beta-endorphin (beta-ED) levels were evaluated in blood and seminal plasma of men with infertility due to varicocele, obstructive and nonobstructive azoospermia, and idiopathic oligoasthenospermia. The relation of this opiate to serum levels of gonadotropins, prolactin, testosterone, androstenedione, and dehydroepiandrosterone sulfate has also been investigated. beta-ED levels in seminal plasma were significantly higher than in blood plasma (p less than 0.001) in all persons studied. No statistically significant differences were found for beta-ED concentrations in semen or blood among any of the infertility situations studied. Nor were significant correlations observed between the concentration of this opiate and that of gonadotropins, prolactin, and androgens. The measurement of beta-ED in semen has little value in the differential diagnosis of male infertility. Nonetheless, its presence in high levels in semen must have some unknown function. Possibly, it comes from the various sites of the male reproductive tract, since no significant differences were found between obstructive and nonobstructive azoospermias.
Subject(s)
Endorphins/analysis , Infertility, Male/physiopathology , Androstenedione/blood , Dehydroepiandrosterone/blood , Endorphins/blood , Follicle Stimulating Hormone/blood , Humans , Luteinizing Hormone/blood , Male , Prolactin/blood , Semen/analysis , Testosterone/blood , beta-EndorphinABSTRACT
The urinary kinetics of triiodothyronine (T3) in healthy young and old people has been studied. The behavior of urinary excretion is similar in both age groups, expressed in our mathematical model in the cumulative kinetics as well as in the urinary rate. However, a significant decrease (P less than 0.025) of renal clearance of T3 in elderly individuals has been found. No significant differences (P greater than 0.05) were observed in any other kinetic parameters. The possible influence of the reduction of glomerular filtrate has been discussed as the most important pathogenic factor of the decreased renal clearance of this hormone. Possibly, modifications of the distribution volumes are also involved. Due to the limited number of persons studied, for ethical reasons, the results obtained are not definitive.
