Subject(s)
Histiocytoma, Benign Fibrous/pathology , Hyperpigmentation/pathology , Mucinoses/pathology , Nevus/pathology , Adult , Biopsy, Needle , Comorbidity , Histiocytoma, Benign Fibrous/complications , Histiocytoma, Benign Fibrous/physiopathology , Humans , Hyperpigmentation/physiopathology , Immunohistochemistry , Male , Monitoring, Physiologic , Mucinoses/physiopathology , Nevus/physiopathology , PrognosisSubject(s)
Convalescence , Enterocolitis, Pseudomembranous/complications , Psychophysiologic Disorders/complications , Self-Injurious Behavior/diagnosis , Sepsis/etiology , Skin Care/adverse effects , Skin Ulcer/diagnosis , Skin Ulcer/psychology , Aged , Anti-Bacterial Agents/therapeutic use , Antifungal Agents/therapeutic use , Antiparasitic Agents/therapeutic use , Clostridioides difficile/isolation & purification , Face , Female , Humans , Self-Injurious Behavior/complications , Self-Injurious Behavior/psychology , Sepsis/drug therapy , Simplexvirus/isolation & purification , Skin Ulcer/drug therapy , Skin Ulcer/pathology , Stomatitis, Herpetic/diagnosis , Stomatitis, Herpetic/virology , Unconsciousness/etiologyABSTRACT
We present an extremely rare case of low-grade cylindromatous adnexal carcinoma (CAC) on the right chest wall of a 77-year-old man. Histopathologically, the neoplasm was initially diagnosed as a cylindroma that developed over the course of 13 years. A diagnosis of low-grade CAC was rendered after the documentation of a local recurrence and histopathology of the recurrent tumor. To further assess the evolution of low-grade CAC over time, we compared the morphology, mitotic account, proliferative markers and adhesion molecule immunoreactivity among paired primary and recurrent tumors. Unlike those earlier reported, our case showed the maintenance of tumor morphology after a recurrence without areas of obvious malignant transformation or metaplastic change. We showed here for the first time the expression of adhesion molecules of CAC/spiradenoma and a comparison of proliferation indices between a primary tumor and its local recurrence. This peculiar tumor differs from previously reported cases and harbors a malignant potential although the histopathological features of malignancy are subtle. Our meta-analysis of the literature provided background information regarding this rare entity. Alterations of E-cadherin and GCDFP-15 expression may provide additional helpful clues in differential diagnosis and determining the clinical behavior of this unusual neoplasm. Further studies are warranted to confirm the potential discriminative role of these markers.
Subject(s)
Autoantibodies/metabolism , Cell Adhesion Molecules/immunology , Pemphigoid, Benign Mucous Membrane/immunology , Cell Adhesion Molecules/chemistry , Humans , Laminin , Male , Middle Aged , Pemphigoid, Benign Mucous Membrane/drug therapy , Pemphigoid, Benign Mucous Membrane/pathology , Prednisolone/therapeutic use , Protein Subunits , KalininSubject(s)
Antimetabolites, Antineoplastic/administration & dosage , Lymphoma, Large-Cell, Anaplastic/drug therapy , Methotrexate/administration & dosage , Skin Neoplasms/drug therapy , Aged , Biomarkers, Tumor/analysis , Biopsy , Female , Humans , Immunohistochemistry , Injections, Intralesional , Lymphoma, Large-Cell, Anaplastic/chemistry , Lymphoma, Large-Cell, Anaplastic/immunology , Lymphoma, Large-Cell, Anaplastic/pathology , Skin Neoplasms/chemistry , Skin Neoplasms/immunology , Skin Neoplasms/pathology , Treatment OutcomeABSTRACT
BACKGROUND: To improve health outcomes during the treatment for pruritic skin diseases, it is important to understand which factors most influence patients' concerns about oral antihistamine drugs. OBJECTIVES: To survey the nature of patients' concerns about oral antihistamine drugs and to examine the factors associated with them. METHODS: Patients with pruritic skin diseases expressed their concerns regarding the use of oral antihistamine drugs. The independent effects of the patients' background characteristics on their concerns were examined by multiple logistic regression analysis. RESULTS: A total of 291 outpatients were completed the study. Overall, 32% of patients were worried about using oral antihistamine drugs. The most common concern was about their adverse drug events (except drowsiness) and the effects of long-term use. Overall, being concerned about antihistamine use was found to be significantly and independently associated with a younger age, severe itching, being a homemaker, and having previous personal experience of embarrassment due to drowsiness caused by taking over-the-counter drugs. CONCLUSIONS: Several factors are associated with altered self-reported concerns about antihistamines. Our results suggest the importance of understanding the nature of patients' fears about oral antihistamine use so that sound advice can be offered to them in a timely manner.
