Multiwall Carbon Nanotube Composites as Artificial Joint Materials.

Because ultrahigh-molecular-weight polyethylene (UHMWPE) is susceptible to frictional wear when used in sliding members of artificial joints, it is common practice to use cross-linked UHMWPE instead. However, cross-linked UHMWPE has low impact resistance; implant breakage has been reported in some cases. Hence, sliding members of artificial joints pose a major trade-off between wear resistance and impact resistance, which has not been resolved by any UHMWPE. On the other hand, multiwall carbon nanotubes (MWCNTs) are used in industrial products for reinforcement of polymeric materials but not used as biomaterials because of their unclear safety. In the present study, we attempted to solve this trade-off issue by complexing UHMWPE with MWCNTs. In addition, we assessed the safety of these composites for use in sliding members of artificial joints. The results showed the equivalence of MWCNT/UHMWPE composites to cross-linked UHMWPE in terms of wear resistance and to non-cross-linked UHMWPE in terms of impact resistance. In addition, all MWCNT/UHMWPE composites examined complied with the requirements of biosafety testing in accordance with the ISO10993-series specifications for implantable medical devices. Furthermore, because MWCNTs can occur alone in wear dust, MWCNTs in an amount of about 1.5 times that contained in the dust produced from 50 years of wear (in the worst case) were injected into rat knees, which were monitored for 26 weeks. Although mild inflammatory reactions occurred in the joints, the reactions soon became quiescent. In addition, the MWCNTs did not migrate to other organs. Furthermore, MWCNTs did not exhibit carcinogenicity when injected into the knees of mice genetically modified to spontaneously develop cancer. The MWCNT/UHMWPE composite is a new biomaterial expected to be safe for clinical applications in both total hip arthroplasty and total knee arthroplasty as the first sliding member of artificial joints to have both high wear resistance and high impact resistance.

Anxiety before dental surgery under local anesthesia: reducing the items on state anxiety in the State-Trait Anxiety Inventory-form X.

BACKGROUND: It is important to evaluate preoperative anxiety and prepare sedation when performing dental surgery under local anesthesia. Spielberger's State-Trait Anxiety Inventory (STAI) is useful for predicting preoperative anxiety. State anxiety is defined as a subjective feeling of nervousness. Reduction in the number of the state anxiety items (questions) will be clinically important in allowing us to predict anxiety more easily. METHODS: We analyzed the STAI responses from 1,252 patients who visited our institution to undergo dental surgery under local anesthesia. Multiple linear regression analysis was conducted for 9 groups comprising anxiety level determinations using the STAI; we then developed a coefficient of determination and a regression formula. We searched for a group satisfying the largest number of requirements for regression expression while setting any necessary conditions for accurately predicting anxiety before dental surgery under local anesthesia. RESULTS: The regression expression from the group determined as normal for preoperative state anxiety was deemed the most suitable for predicting preoperative anxiety. CONCLUSIONS: It was possible to reduce the number of items in the STAI by focusing on "Preoperative anxiety before dental surgery."

Verification of Implant Surface Modification by a Novel Processing Method.

Metals have been used clinically as biomaterials, especially in the orthopaedic and dental fields. Metals used as implants wear at contact surfaces, producing metal particles and metal ions that may be harmful. Newly developed metal implants and methods of implant surface modification are currently under scrutiny. We evaluated the use of electrolytic in-process dressing (ELID) as a surface finishing method for metal implants. Metal implants processed using the ELID method (ELID group) or not processed (Non-ELID group) were inserted surgically into rabbit femurs. The rabbits were sacrificed postoperatively over a 24-week period. We assessed the concentrations of the cytokines, interleukin (IL)-1ß, IL-6, and tumor necrosis factor-α, the resistance to implant pull-out, and histopathology at the implant site. There was no significant difference between the groups regarding the cytokine concentrations or implant pull-out resistance. Many particles indicating wear around the implant were noted in the Non-ELID group (n=10) but not the ELID group (n=13), while a fibrous membrane adhering to the every implant was noted in the ELID group. The formation of a fibrous membrane rather than metal particles in the ELID group may indicate improved biocompatibility, and it suggests that ELID may prevent corrosion in the areas of contact.

Polyethylene Wear Associated With 26- and 32-mm Heads in Total Hip Arthroplasty: A Multicenter, Prospective Study.

BACKGROUND: Although there were many clinical studies of highly cross-linked polyethylene (XLPE) wear among different femoral head diameters, few referred to thickness of XLPE in case larger femoral heads were used because smaller sockets were frequently used for Asian population. METHODS: This prospective study included 240 hips that underwent primary total hip arthroplasty using XLPE combined with 26-mm (group S) or 32-mm (group L) cobalt-chromium head with maximum follow-up of 10 years. We measured 3-dimensional (3-D) linear penetration rate of XLPE among same implant design groups except head diameter and estimated the validity of thinner XLPE. RESULTS: Our study demonstrated comparable 3-D linear penetration rates, which were 0.06 ± 0.07 mm/y for group S and 0.03 ± 0.02 mm/y for group L at 10 years after surgery and penetration rates seemed to be almost constant with no significant difference after 3 years. Minimum liner thickness (5.3 mm for 48-mm socket in combination with 32-mm femoral head) and the second thinnest XLPE (6.3 mm in case of socket from 50 mm to 54 mm combined with 32-mm femoral head) was distributed in 25% and 72% with group L, respectively, and there were no significant differences in penetration rates between 5.3-mm- and 6.3-mm-thickness groups. CONCLUSION: Our study suggested that whether to select 26- or 32-mm diameters of femoral head does not affect XLPE wear in combination with this type of articulation.

Biomechanical comparison of the fixation after curved periacetabular osteotomy using titanium and bioabsorbable screws.

PURPOSE: We performed curved periacetabular osteotomy, a modification of the Bernese periacetabular osteotomy, to treat hip dysplasia. The purpose of our study was to compare the biomechanical stability of acetabular fragments fixed in place with 3 titanium screws, or with 2 or 3 bioabsorbable screws composed of particulate resorbable uncalcined hydroxyapatite (HA) and poly-L-lactic acid (PLLA) termed HA/PLLA screws. METHODS: Curved periacetabular osteotomy was performed on 24 composite model hemipelves. Three groups of 8 specimens were affixed with 1) 3 titanium screws, 2) 2 HA/PLLA screws, or 3) 3 HA/PLLA screws. After fixation, the hemipelves were biomechanically attested with simulated push-off phase of the gait cycle using a servohydraulic material testing system. RESULTS: The average failure loads were not significantly different among the3 groups tested. However, the group repaired with 3 HA/PLLA screws showed significantly greater stiffness than the other groups. CONCLUSIONS: All 3 fixation methods provided sufficient stability to allow for early partial weight-bearing after surgery. The use of 3 HA/PLLA screws provided significantly greater stiffness for acetabular fragment fixation.

Analysis of medialisation of the femoral head in periacetabular osteotomy using three-dimensional computed tomography.

BACKGROUND: Periacetabular osteotomy has been established as an effective treatment for osteoarthritis caused by developmental dysplasia of the hip. Medialisation of the femoral head during periacetabular osteotomy is crucial for providing significant reduction in joint contact stress. The purpose of this study was to evaluate effective procedures for medialisation of the femoral head during periacetabular osteotomy using three-dimensional computed tomography (3DCT). METHODS: Thirty hips in 30 patients with hip dysplasia underwent both radiographic and 3DCT scans before and after surgery. The direction of the rotation of the acetabular fragment and movement of the femoral head were evaluated to analyse which parameters contributed to medialisation of the femoral head. RESULTS: Anterior coverage of the acetabular fragment and internal rotation in the axial plane contributed to both medialisation of the femoral head and anteversion of the retroverted acetabulum. CONCLUSIONS: This study demonstrated that re-orientation of the acetabulum was spatially confirmed by the method using 3DCT images.

A comparison of dynamic rotational knee instability between anatomic single-bundle and over-the-top anterior cruciate ligament reconstruction using triaxial accelerometry.

PURPOSE: Recently, single-bundle (SB) anterior cruciate ligament (ACL) reconstruction has been advanced by the anatomic concept, but the biomechanical outcome of the anatomic method has not been fully investigated, especially for rotational instability. Anatomic SB and the single over-the-top procedures are the treatment of choice for primary cases and revision or skeletally immature cases, respectively. The purpose of this study was to investigate the dynamic rotational instability of anatomic SB and over-the-top reconstruction during a pivot shift test using triaxial accelerometry. METHODS: Eight fresh frozen human cadaveric knees were used in this study. Rotational instability measurement was conducted during a pivot shift test by the use of a triaxial accelerometer attached to the tibia. The tests were performed in the ACL-intact, ACL-deficient and ACL-reconstructed knees with two different procedures (anatomic SB and over-the-top). The acceleration in three directions and the magnitude of acceleration were measured to evaluate rotational instability and compare between four different knee states. RESULTS: The overall magnitude of acceleration was significantly different (P < 0.01) between the ACL-intact knees and the ACL-deficient knees. Both anatomic SB and over-the-top ACL reconstruction significantly reduced the overall magnitude of acceleration compared to the ACL-deficient knees, but still had larger accelerations compared to the ACL-intact knees. There was no significant difference for the overall magnitude of acceleration between anatomic SB and over-the-top reconstruction procedure. CONCLUSION: Over-the-top reconstruction provides comparable result to anatomic SB reconstruction in terms of controlling the dynamic rotational stability. Over-the-top reconstruction might be one of the options for revision cases and in skeletally immature patients.

Three lateral osteotomy designs for bilateral sagittal split osteotomy: biomechanical evaluation with three-dimensional finite element analysis.

BACKGROUND: The location of the lateral osteotomy cut during bilateral sagittal split osteotomy (BSSO) varies according to the surgeon's preference, and no consensus has been reached regarding the ideal location from the perspective of biomechanics. The purpose of this study was to evaluate the mechanical behavior of the mandible and screw-miniplate system among three lateral osteotomy designs for BSSO by using three-dimensional (3-D) finite element analysis (FEA). METHODS: The Trauner-Obwegeser (TO), Obwegeser (Ob), and Obwegeser-Dal Pont (OD) methods were used for BSSO. In all the FEA simulations, the distal segments were advanced by 5 mm. Each model was fixed by using miniplates. These were applied at four different locations, including along Champy's lines, to give 12 different FEA miniplate fixation methods. We examined these models under two different loads. RESULTS: The magnitudes of tooth displacement, the maximum bone stress in the vicinity of the screws, and the maximum stress on the screw-miniplate system were less in the OD method than in the Ob and TO methods at all the miniplate locations. In addition, Champy's lines models were less than those at the other miniplate locations. CONCLUSIONS: The OD method allows greater mechanical stability of the mandible than the other two techniques. Further, miniplates placed along Champy's lines provide greater mechanical advantage than those placed at other locations.

Modified pubic osteotomy for medialization of the femoral head in periacetabular osteotomy: a retrospective study of 144 hips.

BACKGROUND AND PURPOSE: Medial displacement of the femoral head reduces the force transmitted across the hip joint. Since 2005, we have performed a modified Ganz's osteotomy with curved periacetabular osteotomy (CPO) to obtain medialization of the femoral head. The modification involves cutting of the pubis at 30 degrees to the horizontal line. Here, we examined whether this modified CPO procedure medialized the femoral head more than the conventional CPO procedure. PATIENTS AND METHODS: 69 patients (mean age 37 years, 72 hips) treated with the modified CPO procedure (the M group) were compared with 68 patients (mean age 38 years, 72 hips) previously treated with conventional CPO (the C group). All patients were operated because of dysplastic hips. We used radiographic measurements from anteroposterior radiographs. The magnitude of the resultant hip force normalized with respect to the body weight (R/WB) and hip contact joint stress (Pmax/ WB) was calculated in all cases. RESULTS: The average lateral center-edge (CE) angle, acetabular roof obliquity (ARO), and acetabulum-head index (AHI) improved in both groups. The CE angle, ARO, and AHI were similar in the 2 groups before and after surgery. Medialization of the femoral head was larger in the M group than in the C group (p < 0.001). The average value of the resultant hip force decreased from 3.2 to 2.9 in the M group and remained unchanged, at 3.1, in the C group. In addition, the average value of the peak contact stress decreased more in the M group (from 9.4 kPa/N to 3.4 kPa/N) than in the C group (from 9.1 kPa/N to 4.3 kPa/N). INTERPRETATION: In dysplastic hips, the modified CPO reduces the contact hip stress more than the conventional CPO because of better medialization of the femoral head.

Evaluation of dynamic instability of the dysplastic hip with use of triaxial accelerometry.

BACKGROUND: Dysfunction of the hip secondary to dysplasia is a complex problem that includes excessive stresses on the articular cartilage, dynamic hip instability, and muscular fatigue, eventually leading to degenerative arthritis if left uncorrected. Mechanical stress on the dysplastic hip has been widely described, but dynamic instability requires further evaluation. The purpose of this study was to investigate dynamic instability of the dysplastic hip with use of triaxial accelerometry. METHODS: We evaluated forty-eight hips of twenty-four patients with unilateral hip dysplasia (a center-edge angle of <25 degrees ). All contralateral hips were disease-free with normal radiographic findings. An accelerometer was used to record triaxial acceleration while the patient was walking (x-axis: superoinferior direction, y-axis: anteroposterior direction, and z-axis: mediolateral direction). Sensors were attached to the skin, with adhesive tape, over the greater trochanter and the anterior superior iliac spine bilaterally. The time of heel-strike was confirmed visually and by superoinferior acceleration. The averages of the peak values of the middle three gait cycles were used for data analysis. The overall magnitude of acceleration was calculated to evaluate hip instability. The overall magnitudes of acceleration of the dysplastic and contralateral, normal hips were compared with the radiographic data. RESULTS: The three directions of acceleration were the same in all cases. The overall magnitude of acceleration of the dysplastic hips was significantly larger than that of the contralateral, normal hips (p < 0.0001). There was a negative correlation between the overall magnitude of acceleration and both the center-edge angle and the acetabular head index, and there was a positive correlation between the overall magnitude of acceleration and both the acetabular roof angle and the Sharp angle. CONCLUSIONS: Hip instability is increased in proportion to the degree of dysplasia. Triaxial accelerometry is helpful in the evaluation of dynamic instability of the dysplastic hip. The center-edge angle can be used as an indicator of hip instability.

Tensile properties of the human acetabular labrum-the first report.

The tensile properties of the human acetabular labrum were investigated using a uniaxial tension testing apparatus. The superior quadrant of the acetabular labrum was harvested from patients who underwent hip surgery. The obtained labra were sliced and shaped into rectangles for measuring uniaxial tension. We hypothesized that several characteristics such as gender, age, degeneration due to primary ailment, and the severity of the acetabular dysplasia would influence the tensile properties of the labrum. Antero-posterior radiographs of the pelvis have been used to evaluate the severity of the acetabular dysplasia and to diagnose the developmental dysplasia of the hip joint (DDH) clinically. Thus, we investigated the correlation between each of two representative radiological measurements-the CE angle and the Sharp angle-and tensile properties to assess the influence of the severity of the acetabular dysplasia. The tensile stress-strain curves for the labrum assumed a sigmoid shape. The mean tensile stress at failure for all specimens was 8.8+/-4.1 MPa. The mean strain at failure for all specimens was 48.5+/-10.4%. The mean tensile modulus was 66.4+/-42.2 MPa. Mean tensile stress at failure for specimens from males was greater than that of specimens from females. A significant difference was found in the maximum stress at failure among the three diagnosis-based groups: the other group withstood the highest stress before failure, whereas the osteoarthritis (OA) group withstood the lowest. No significant correlations with age or radiological characteristics were found for tensile stress, strain at failure, or tensile modulus. Our results suggest that labra obtained from male patients have stronger tensile stress than those from female patients, and that degenerative changes may influence the properties of the acetabular labrum.