ABSTRACT
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Subject(s)
Humans , Male , Female , Child , Adolescent , Thyroid Neoplasms/diagnosis , Carcinoma/diagnosis , Thyroid Neoplasms/surgery , Time FactorsSubject(s)
Thyroid Neoplasms/diagnosis , Adolescent , Child , Female , Humans , Male , Thyroid Neoplasms/surgery , Time FactorsABSTRACT
Antecedentes y objetivo El cáncer diferenciado de tiroides (CDT) es el tumor endocrino más frecuente, con buen pronóstico y supervivencias superiores al 85%. El objetivo de nuestro trabajo es conocer la supervivencia actual de nuestra serie de CDT y analizar los factores relacionados. Pacientes y métodos Realizamos un estudio retrospectivo de una cohorte de pacientes con CDT (n: 308), 93,5% eran papilares, el 78,2% eran mujeres con una edad media al diagnóstico de 45,4±15,8 años y un tiempo de seguimiento de 8,9 ± 6,8 años. Han sido tratados y seguidos de forma homogénea en nuestro centro hospitalario. Para cada paciente se ha recogido edad al diagnóstico, sexo, histología, estadio TNM, tratamientos empleados y fecha y causa de la muerte. La probabilidad de supervivencia fue calculada por el método de Kaplan Meier. Para analizar los factores relacionados con la supervivencia se realizó un análisis univariante (Log Rank test) y multivariante (Riesgos proporcionales de Cox).Resultados Se produjeron 26 casos de muerte, de ellos 15 pacientes (4,9%) murieron como consecuencia del CDT. La probabilidad de supervivencia acumulada del grupo total fue del 92,7%. En el análisis multivariante las variables asociadas de forma independiente con mortalidad por CDT fueron: metástasis a distancia, tipo histológico folicular, edad al diagnóstico más de 60 años y afectación extratiroidea. Discusión La probabilidad de supervivencia de nuestra serie es equiparable a la de la literatura. El conocimiento de los factores relacionados con peor supervivencia en el medio que trabajamos, es importante para establecer estrategias más activas de tratamiento en pacientes de alto riesgo (AU)
Background and aims Differentiated thyroid carcinoma (DTC) is the most common endocrine tumor. DTC has a good prognosis and survival rates higher than 85%. The aim of our study was to assess our current survival rate and to analyze prognostic factors. Patients and methods A retrospective analysis was conducted of 308 patients with DTC (93.5% with papillary tumors, 78.8% women). Mean age at diagnosis was 45.4±15.8years, and mean follow-up time was 8.9±6.8 years. The whole group was treated and followed up using the same protocol at our hospital. The following data were collected: age at diagnosis, sex, histology, TNM stage, treatments, and date and cause of death. Survival probability was calculated using Kaplan-Meier analyses. Prognostic factors were analyzed using a univariate log rank test and a multivariate Cox regression analysis model. Results Twenty-six patients died during follow-up, 15 of them (4.9%) from DTC. Thyroid carcinoma-related survival was 92.7% for the whole group. In multivariate analyses, the following parameters were associated to a significantly increased risk of death from DTC: presence of distant metastases, follicular histology, age at diagnosis older than 60 years, and extrathyroid invasion. Discussion Our survival rate is similar to that reported in literature. Assessment of prognostic factors related to an increased risk of death in our patient group, is essential to establish active therapeutic approaches in high risk patients (AU)
Subject(s)
Humans , Carcinoma/epidemiology , Thyroid Neoplasms/epidemiology , Retrospective Studies , Carcinoma/pathology , Thyroid Neoplasms/pathology , Risk Factors , Survival RateABSTRACT
BACKGROUND AND AIMS: Differentiated thyroid carcinoma (DTC) is the most common endocrine tumor. DTC has a good prognosis and survival rates higher than 85%. The aim of our study was to assess our current survival rate and to analyze prognostic factors. PATIENTS AND METHODS: A retrospective analysis was conducted of 308 patients with DTC (93.5% with papillary tumors, 78.8% women). Mean age at diagnosis was 45.4±15.8years, and mean follow-up time was 8.9±6.8years. The whole group was treated and followed up using the same protocol at our hospital. The following data were collected: age at diagnosis, sex, histology, TNM stage, treatments, and date and cause of death. Survival probability was calculated using Kaplan-Meier analyses. Prognostic factors were analyzed using a univariate log rank test and a multivariate Cox regression analysis model. RESULTS: Twenty-six patients died during follow-up, 15 of them (4.9%) from DTC. Thyroid carcinoma-related survival was 92.7% for the whole group. In multivariate analyses, the following parameters were associated to a significantly increased risk of death from DTC: presence of distant metastases, follicular histology, age at diagnosis older than 60years, and extrathyroid invasion. DISCUSSION: Our survival rate is similar to that reported in literature. Assessment of prognostic factors related to an increased risk of death in our patient group, is essential to establish active therapeutic approaches in high risk patients.
