Breast cancer treatment and outcomes at Cape Coast Teaching Hospital, Ghana.

Objectives: This study sought to determine the presentation, treatment and outcomes of breast cancer among women in Cape Coast, Ghana. Design: Retrospective medical record review. Setting: Cape Coast Teaching Hospital, Cape Coast, Ghana. Participants: Female breast cancer patients. Interventions: None. Main outcome measures: Proportion of female breast cancer patients presenting with advanced disease. Results: Approximately 84% of women had a primary presentation of breast cancer, with metastatic disease present in 34% of patients. Surgical management mainly involved partial mastectomy (21.7%) and total mastectomy (78.6%), with the most common postoperative complications being surgical site infections (3.8%). Non-surgical management involved chemotherapy, radiation therapy and anti-estrogen therapy, with Stage 3 and 4 patients twofold more likely to receive neoadjuvant chemotherapy than earlier stages (OR= 2.0 95% CI (1.4, 3.0, p<0.001). Grade 1 cancers were diagnosed in 11.0%, Grade 2 in 43.8%, and Grade 3 in 45.2%. The mean cancer size was 6.5 centimetres (range 1.5 to 20.0). Lymphatic vascular invasion was present in 59/125 (47.2%), estrogen receptor status was positive in 32.6%, progesterone receptors were positive in 22.1%, and Her-2/neu was positive in 32.6%. Triple-negative breast cancer was identified in 41/89 (46.1%). Conclusions: Women with breast cancer typically present to the Cape Coast Teaching Hospital with advanced stage disease and experience poor outcomes. Funding: Funding for this study was provided by the Harvard Medical School Scholars in Medicine.

Assessment of iodine status among pregnant women in a rural community in ghana - a cross sectional study.

BACKGROUND: Pregnancy is associated with parallel increase in both iodine, and thyroid hormone requirements suggesting that, there may be the need for additional iodine intake during this period to prevent potential iodine insufficiency. Medically, an excess or reduced intake of this micronutrient has negative effects on the individual's health. This study aimed at identifying the pattern of iodine levels among pregnant women at Kissi, Ghana. METHOD: A cross-sectional study was carried out among pregnant women on antenatal care at Kissi Health Centre (KHC) which serves the rural town with a population of about 4,500, located in the Komenda/Edina/Eguafo/Abirem (KEEA) municipality in the Central Region of Ghana. Demographic information, iodated salt usage and other pertinent information such as tobacco use were captured using a questionnaire. In addition, urine iodine concentration was estimated through the Ammonium per sulfate method after collecting on-the-spot urine samples. RESULTS: Prevalence of iodine deficiency in pregnant women was 42.5 %. Of the 80 participants who were on iodized salt, only 16.25 % had mild iodine deficiency with none suffering from moderate or severe iodine deficiency. Of the 40 participants who did not use iodized salt, 35 %, 30 %, and 30 % suffered from severe, moderate and mild iodine deficiency respectively. CONCLUSION: The high prevalence of iodine deficiency reported in this study suggests that urgent national measures are required to correct iodine insufficiency in pregnant women in these communities.