ABSTRACT
The reliability of the results of serological examination in diagnostics of associated infections was studied on a model of artificially provoked vaccinal infections in humans and in laboratory animals. The effect of administered monopreparations on changes in the level of both homologous and heterologous antibodies was tested. The character of immunological changes following simultaneous administration of two or more respiratory viruses was analysed and the effect of these viruses in diseases of divers etiology was studied. According to the results of experiments on laboratory animals, repeated administration of any of the earlier used respiratory viruses stimulated the accumulation of only homologous antibodies while heterologous antibodies did not increase at all.
Subject(s)
Respiratory Tract Infections/diagnosis , Serologic Tests , Virus Diseases/diagnosis , Adenoviridae/immunology , Administration, Intranasal , Administration, Oral , Animals , Antibodies, Viral/biosynthesis , Antibody Specificity , Child , Child, Preschool , Clinical Trials as Topic , Cricetinae , Diagnosis, Differential , Humans , Immunization , Influenza Vaccines/administration & dosage , Neutralization Tests , Placebos , Respiratory Syncytial Viruses/immunology , Respirovirus/immunology , Vaccines, Attenuated/administration & dosage , Viral Vaccines/administration & dosageABSTRACT
The reliability of the results of serological examination in diagnostics of associated infections was studied on a model of artificially provoked vaccinal infections in humans and in laboratory animals. The effect of administered monopreparations on changes in the level of both homologous and heterologous antibodies was tested. The character of immunological changes following simultaneous administration of two or more respiratory viruses was analysed and the effect of these viruses in diseases of divers etiology was studied. According to the results of experiments on laboratory animals, repeated administration of any of the earlier used respiratory viruses stimulated the accumulation of only homologous antibodies while heterologous antibodies did not increase at all. The results revealed the possibility of simultaneous immunological reorganization of a child's organism in response to the influence of several different antigens from the group of respiratory viruses acting synchronously or in succession. Results of the analysis demonstrated the reliability of the employed serological methods of diagnosis of respiratory virus infections.
