Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral ß-Amyloidosis in AßPP/PS1 Transgenic Mice.

Two tetrapeptides, HAEE and RADD, which are ionic-complementary to the primary zinc recognition site of amyloid-ß (Aß), have been reported to inhibit zinc-induced dimerization of the Aß metal-binding domain and slow Aß aggregation in vitro. In the present study, we investigate the impact of HAEE and RADD on the development of cerebral ß-amyloidosis in a mouse model of Alzheimer's disease. We have found chronic intravenous administration of each peptide results in significant decrease of amyloid plaque burden in the treated mice.