[The clinical picture, diagnosis and treatment of the stomatological manifestations of Sjögren's disease]. / Klinika, diagnostika i lechenie stomatologicheskikh proiavlenii bolezni Shegrena.

Eighty-three patients with Sjogren's disease, 23 with chronic parotitis and periodontitis, 325 controls were examined by general clinical, dental, X-ray, microbiological, immunological, and morphological methods. A clinico-pathogenetic analysis of dental manifestations of Sjogren's disease was carried out: atrophy and inflammatory process in the buccal mucosa, multiple caries. A pathogenetically based program of therapeutic and prophylactic measures making use of encad, bensilol, bensilol+trimecain is suggested for patients with Sjogren's disease.

[The use of the new bacterial biopreparation Acilact in the combined treatment of periodontitis]. / Primenenie novogo bakterial'nogo biopreparata "Atsilakt" v kompleksnom lechenii parodontita.

Acilact, a bacterial biopreparation representing a complex of live lyophilized acidophilic lactobacteria, was used in combined therapy of 45 patients with periodontitis of mild and medium severity. The drag was applied locally and per os. Clinical parameters improved after therapy; gram-positive cocci and bacilli predominated in local microflora; natural antibacterial resistance of the body improved. This method of therapy is new in principle and pathogenetically grounded. It results in correction of autoflora of the oral cavity and periodontal pouches, and, possibly, of the gastrointestinal tract. Acilact is well tolerated by the patients and induces no side effects, there are no contraindications against its administration.

[Wound infection in the surgical treatment of children with congenital cleft palate]. / Ranevaia infektsiia pri khirurgicheskom lechenii detei s vrozhdennoi rasshchelinoi neba.

Clinico-microbiologic examinations of 153 children with cleft palate aged 2 to 9 were carried out. Two groups of patients with different pattern of operative wound healing after uranoplasty were singled out: 110 ones with primary healing and 13 ones with infectious inflammations of the wound. The incidence of S. aureus carriership on the palatal mucosa before surgery was higher among patients who developed postoperative inflammations. On day 3 after the operation gram-negative bacilli were isolated from the majority of patients with postoperative wound inflammations coursing in the presence of marked dysbacteriosis as against patients in whom the wounds healed by primary intention. The authors suggest a method for wound infection prevention in uranoplasty, consisting in irrigation of the operative wound with acilact (a biopreparation) suspension and shortening of antibiotic prevention course to just 48-72 h; the efficacy of this method was confirmed by a reduction of the incidence of postoperative complications. Normal microflora representatives predominated in the microbiocenosis of the operative wound on days 3 and 10-12 after uranoplasty.

[Antibacterial protection and the microbiological status of the oral cavity in Sjögren's disease]. / Antibakterial'naia zashchita i mikrobiologicheskii status polosti rta pri bolezni Shegrena.

The microflora of the oral cavity was studied with a view to the evaluation of the microbiological status and the content of lysozyme in mixed saliva samples from 14 patients with Sjögren's syndrome and the control group of 19 persons. Disturbances in the biocenosis of the oral cavity of the patients, characterized by the increased occurrence of rod-shaped forms of lactobacilli, yeast-like fungi of the genus Candida and cariogenic streptococci (S. mutans) in the cultures obtained by the inoculation of oral smears, was detected. This "cariogenic situation" was confirmed by clinical data on the stomatological status. In patients with Sjögren's syndrome the intensity of caries, determined by the ratio of carious, filled and extracted teeth, was high and reached 27.4 +/- 1.0 in comparison with 15.3 +/- 0.7 in the control group (P less than 0.05). A decrease in the level of mixed saliva secretion and in the content of lysozyme in secreted saliva was noted in the patients in comparison with the control group (P less than 0.05). The results thus obtained indicate that in Sjögren's syndrome the use of the preparations of eubiotic microorganisms with a view to the correction of the microflora of the oral cavity, as well as the application of 0.1% lysozyme solution to the mucous membrane of the oral cavity, may be recommended among other therapeutic measures.