ABSTRACT
There were studied up the peripheral blood indices in 109 patients, suffering odontogenic phlegmon (OPH), coexistant with severe and of medium severity systemic inflammatory response syndrome (SIRS). In the patients with OPH and severe SIRS (with the complicated course), the blood neutrophils indices, concerning endogenic intoxication and functional activity, differ essentially from those parameters, present in patients, suffering noncomplicated course of the disease.
Subject(s)
Cellulitis/surgery , Focal Infection, Dental/surgery , Neutrophils , Systemic Inflammatory Response Syndrome/diagnosis , Adolescent , Adult , Aged , Apoptosis , C-Reactive Protein/analysis , Cellulitis/blood , Cellulitis/etiology , Cellulitis/immunology , Focal Infection, Dental/blood , Focal Infection, Dental/complications , Focal Infection, Dental/immunology , Humans , Leukocyte Count , Luminescent Measurements , Middle Aged , Neutrophils/cytology , Neutrophils/immunology , Neutrophils/pathology , Oligonucleotides/blood , Oligopeptides/blood , Predictive Value of Tests , Prognosis , Systemic Inflammatory Response Syndrome/blood , Systemic Inflammatory Response Syndrome/etiology , Systemic Inflammatory Response Syndrome/immunology , Young AdultABSTRACT
The content of mRNA for alpha-synuclein (a key protein of the dopaminergic system) was elevated in the peripheral lymphocytes of patients with alcohol dependence syndrome. Increased level of alpha-synuclein mRNA was not associated with changes in the expression of NR4A2 gene encoding Nurrl, one of the main transcription factors of dopaminergic neurons.
Subject(s)
Alcoholism/genetics , Genetic Predisposition to Disease , Lymphocytes/metabolism , alpha-Synuclein/genetics , Adult , Analysis of Variance , DNA-Binding Proteins/genetics , Humans , Male , Middle Aged , Nuclear Receptor Subfamily 4, Group A, Member 2 , Transcription Factors/geneticsSubject(s)
Adrenergic beta-Antagonists/therapeutic use , Atrial Fibrillation/drug therapy , Bisoprolol/therapeutic use , Heart Failure/drug therapy , Myocardial Contraction/drug effects , Sotalol/therapeutic use , Tachycardia, Paroxysmal/drug therapy , Adult , Aged , Atrial Fibrillation/complications , Atrial Fibrillation/physiopathology , Exercise Test , Female , Heart Failure/complications , Heart Failure/physiopathology , Humans , Male , Middle Aged , Tachycardia, Paroxysmal/complications , Tachycardia, Paroxysmal/physiopathology , Treatment OutcomeABSTRACT
AIM: Efficacy and tolerability of carvedilol vs captopril were studied at 24-h monitoring of blood pressure (BP) in hypertensive patients with an uncompletated hypertensive crisis (HC). MATERIAL AND METHODS: The trial included 43 patients (23 males and 20 females aged 58 +/- 4.1 years) with an uncomplicated HC (duration of hypertension 9.4 +/- 1.1 years). Twenty patients of group 1 received oral carvedilol (25 mg), 23 patients of group 2--oral captopril (25 mg). The criterion of efficacy was a 15-25% decrease of BP within 60-120 min. RESULTS: Attenuation of HC symptoms and tolerability was the same in both groups. Forty five minutes after the drug intake systolic pressure lowered by 11.1% (p = 0.039) and 10.9% (p = 0.042) in group 1 and 2, respectively; diastolic pressure--by 14.9% (p = 0.037) and 17.9% (p = 0.018), respectively. Heart rate diminished significantly only in group 1 (by 10.9%, p = 0.043) 30 min after carvedilol intake. A maximal BP fall in group 1 occurred 180 min after the drug intake: systolic by 23.5% (p = 0.0001), diastolic by 26.9% (p < 0.0001). In group 2 the BP fall was 23.3% (p < 0.0001) and 29.1% (p < 0.0001) on min 165 and 150, respectively. Systolic and diastolic pressures lowered faster in group 1. The effect of carvedilol lasted longer--372.6 +/- 19.3 min and 245.1 +/- 13.7 min, respectively, p = 0. 0001. CONCLUSION: A hypotensive effect of carvedilol and captopril in hypertensive patients with an uncomplicated HC was the same. Carvedilol produced a longer and a more stable effect.
Subject(s)
Adrenergic alpha-Antagonists/therapeutic use , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Captopril/therapeutic use , Carbazoles/therapeutic use , Hypertension/drug therapy , Propanolamines/therapeutic use , Administration, Oral , Adrenergic alpha-Antagonists/administration & dosage , Adult , Aged , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Blood Pressure/drug effects , Captopril/administration & dosage , Carbazoles/administration & dosage , Carvedilol , Female , Follow-Up Studies , Humans , Hypertension/physiopathology , Male , Middle Aged , Propanolamines/administration & dosage , Treatment OutcomeABSTRACT
There was established high efficacy of method of the low dosed vacuum draining of wound with predominance of putrefactive-necrotic affection was established in patients with phlegmon of maxillofacial region.
