ABSTRACT
Physical development, development of sensory and motor reflexes, behavioral and mnestic patterns were studied infantile and juvenile rat pups born by female rats receiving Afobazole during pregnancy. Physical development and development of sensory and motor reflexes in rats were completed without pathologies by the age of 2 months. During the infantile period, the rat pups demonstrated reduced body weight gain, delayed eye opening and pupillary response formation, decreased muscle force, and suppressed motor behavior. During the juvenile period, body weight gain and development of motor behavior were intensified. Females demonstrated later vagina opening and poorer mnestic responses. In males, the terms of sexual maturation were unchanged and processes of learning and memory retrieval were not impaired.
Subject(s)
Anti-Anxiety Agents/adverse effects , Benzimidazoles/adverse effects , Maternal Exposure/adverse effects , Morpholines/adverse effects , Prenatal Exposure Delayed Effects/etiology , Animals , Animals, Newborn , Avoidance Learning/drug effects , Behavior, Animal/drug effects , Female , Maze Learning/drug effects , Memory/drug effects , Motor Activity/drug effects , Muscle Strength/drug effects , Muscle, Skeletal/drug effects , Muscle, Skeletal/growth & development , Pregnancy , Prenatal Exposure Delayed Effects/physiopathology , Rats , Reflex, Pupillary/drug effects , Sexual Maturation/drug effects , Weight Gain/drug effectsABSTRACT
Experiments on pregnant female rats showed that the beta-phenylglutaminic acid hydrochloride derivative neuroglutam (glutaron), exhibiting antidepressant and anxiolytic activity upon intragastric administration in doses of 26, 130 and 650 mg/kg to female rats from 6 to 16 days of pregnancy, does not impair organo- and fetogenesis processes (developments of fetus) registered during the anthenatal period, decreases fetal death, and activates the processes of prenatal development of the fetus bv 11.1% (p < 0.001), 8.3% (p < 0.001), and 2.8% (p < 0.05), respectively.
Subject(s)
Antidepressive Agents/pharmacology , Fetal Development/drug effects , Organogenesis/drug effects , Animals , Female , Pregnancy , RatsABSTRACT
Experiments on pregnant rats have demonstrated the absence of damaging effect of Afobazole administered during the antenatal period on organogenesis in fetuses. Afobazole in a dose of 5 mg/kg given to pregnant rats on gestation days 6-16 reduced pre- and post-implantation fetal mortality and improved fertility; 20-day-old embryos had no developmental abnormalities and did not differ from controls by craniocaudal size, body weight, and skeleton ossification. Afobazole in a dose of 100 mg/kg reduced pre- and post-implantation fetal mortality, but had no effect on fertility. No congenital malformations were found in the fetuses, but they were characterized by lower craniocaudal size, body weight, and number of ossification foci in the sternum and spine.
Subject(s)
Anti-Anxiety Agents/toxicity , Benzimidazoles/toxicity , Fetal Development/drug effects , Morpholines/toxicity , Organogenesis/drug effects , Pregnancy Complications/drug therapy , Animals , Anti-Anxiety Agents/therapeutic use , Benzimidazoles/therapeutic use , Drug Evaluation, Preclinical , Female , Male , Maternal-Fetal Exchange , Morpholines/therapeutic use , Pregnancy , RatsABSTRACT
Effectiveness of saline suspension of Corynebacterium pseudodiphtheriticum containing spray was assessed in a 30-days chamber experiment modeling the effects of hyperthermia and polluted air on humans. Spray was targeted at eliminating Staphylococcus aureus from the nasal cavity of human subjects. Three of four volunteers became S. aureus carriers in the course of the experiment, and one was a chronic carrier of methicillin-resistant S. aureus (MRSA). Spray application eradicated S. aureus in three subjects and reduced its presence in the MRSA carrier. Results of the study suggest that C. pseudodiphtheriticum can be used for control of S. aureus in the nasal environment. However, further investigations are required.
