[Influence of socio-economic status on the utilization of epidural analgesia during labor]. / Einfluss von Faktoren des sozioökonomischen Status auf die Anwendung der Periduralanästhesie subpartal.

OBJECTIVE: Evaluation of the influence of socio-economic status on the utilization of epidural analgesia during labor. MATERIAL AND METHODS: Modes of delivery, insurance, marital status and maternal occupation were retrospectively reviewed between 2000 and 2003 according to the birth documentation of all deliveries at the department of obstetrics and gynaecology, university of Wuerzburg, Germany. Using the maternal occupation groups were formed according to the minimum degree of education required for its practise. Women with epidural analgesia during labor were compared to those without it. RESULTS: 30 % of all deliveries during the evaluated four years were aided by employing epidural analgesics. For both collectives there were no changes of percentages concerning insurance, marital status or maternal occupation during this time. With 12-24 %, epidural analgesia was more often performed in patients undergoing operative transvaginal deliveries in comparison to women without epidural analgesics (2-5 %). There are no differences between the two groups concerning maternal occupation, insurance or marital status. However, looking at the collective of women with epidural analgesia during labor, epidural analgesia is more often used among women with private insurance. Concerning the degree of education there is also a marginal significant difference in the utilization of epidural analgesia in favour for women with a higher educational degree. CONCLUSION: The use of intrapartum epidural analgesia is associated with insurance and maternal occupation/educational degree.

Heat shock protein 27 is associated with decreased survival in node-negative breast cancer patients.

BACKGROUND: Heat shock protein 27 (hsp27) is a molecular chaperone which supports cells to keep their homeostasis under stressful conditions. It is associated with resistance to chemotherapeutics, radiation and hyperthermia. The aim of this retrospective study was to investigate the prognostic value of hsp27 for patients with node-negative breast cancer. MATERIALS AND METHODS: Paraffin sections of 191 patients were stained immunohistochemically with a monoclonal antibody against hsp27. Median follow-up was 177 months. The results were correlated with clinical and histopathological parameters using the Chi-square test. RESULTS: There was no significant correlation between hsp27 expression and standard histopathological features or the proliferation marker ki-67. Disease-free survival (DFS) was not altered for patients expressing hsp27-positive tumors, whereas overall survival (OS) [p=0. 02] and survival after first recurrence (SR) [p=0.01] were significantly decreased. CONCLUSION: The expression of hsp27 in primary breast cancers is associated with a short survival for node-negative patients.