1.
Chem Commun (Camb)
; (24): 2494-6, 2007 Jun 28.
Article
in English
| MEDLINE
| ID: mdl-17563807
ABSTRACT
3(2H)-Furanones can be prepared by a catalytic asymmetric protocol from enynones, which, if electron-rich, require only one reagent and involve two reactions in a single operation--a domino process.
Subject(s)
Furans/chemistry , Alkynes/chemistry , Catalysis , Furans/chemical synthesis , Models, Molecular , Molecular Structure , Stereoisomerism
2.
Bioorg Med Chem Lett
; 17(1): 136-41, 2007 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-17046252
ABSTRACT
Syntheses of aryloxyalkanoic acid hydroxyamides are described, all of which are potent inhibitors of histone deacetylase, some being more potent in vitro than trichostatin A (IC(50)=3 nM). Variation of the substituents on the benzene ring as well as fusion of a second ring have marked effects on potency, in vitro IC(50) values down to 1 nM being obtained.
