Vocational interests in the United States: Sex, age, ethnicity, and year effects.

Vocational interests predict educational and career choices, job performance, and career success (Rounds & Su, 2014). Although sex differences in vocational interests have long been observed (Thorndike, 1911), an appropriate overall measure has been lacking from the literature. Using a cross-sectional sample of United States residents aged 14 to 63 who completed the Strong Interest Inventory assessment between 2005 and 2014 (N = 1,283,110), I examined sex, age, ethnicity, and year effects on work related interest levels using both multivariate and univariate effect size estimates of individual dimensions (Holland's Realistic, Investigative, Artistic, Social, Enterprising, and Conventional). Men scored higher on Realistic (d = -1.14), Investigative (d = -.32), Enterprising (d = -.22), and Conventional (d = -.23), while women scored higher on Artistic (d = .19) and Social (d = .38), mostly replicating previous univariate findings. Multivariate, overall sex differences were very large (disattenuated Mahalanobis' D = 1.61; 27% overlap). Interest levels were slightly lower and overall sex differences larger in younger samples. Overall sex differences have narrowed slightly for 18-22 year-olds in more recent samples. Generally very small ethnicity effects included relatively higher Investigative and Enterprising scores for Asians, Indians, and Middle Easterners, lower Realistic scores for Blacks and Native Americans, higher Realistic, Artistic, and Social scores for Pacific Islanders, and lower Conventional scores for Whites. Using Prediger's (1982) model, women were more interested in people (d = 1.01) and ideas (d = .18), while men were more interested in things and data. These results, consistent with previous reviews showing large sex differences and small year effects, suggest that large sex differences in work related interests will continue to be observed for decades. (PsycINFO Database Record

Disposition of caspofungin, a novel antifungal agent, in mice, rats, rabbits, and monkeys.

The metabolism, excretion, and pharmacokinetics of caspofungin (Cancidas; Merck & Co., Inc.) were investigated after administration of a single intravenous dose to mice, rats, rabbits, and monkeys. Caspofungin had a low plasma clearance (0.29 to 1.05 ml/min/kg) and a long terminal elimination half-life (11.7 h to 59.7 h) in all preclinical species. The elimination kinetics of caspofungin were multiphasic and displayed an initial distribution phase followed by a dominant beta-elimination phase. The presence of low levels of prolonged radioactivity in plasma was observed and was partially attributable to the chemical degradation product M0. Excretion studies with [(3)H]caspofungin indicated that the hepatic and renal routes play an important role in the elimination of caspofungin, as a large percentage of the radiolabeled dose was recovered in urine and feces. Excretion of radioactivity in all species studied was slow, and low levels of radioactivity were detected in daily urine and fecal samples throughout a prolonged collection period. Although urinary profiles indicated the presence of several metabolites (M0, M1, M2, M3, M4, M5, and M6), the majority of the total radioactivity was associated with the polar metabolites M1 [4(S)-hydroxy-4-(4-hydroxyphenyl)-L-threonine] and M2 [N-acetyl-4(S)-hydroxy-4-(4-hydroxyphenyl)-L-threonine]. Caspofungin was thus primarily eliminated by metabolic transformation; however, the rate of metabolism was slow. These results suggest that distribution plays a prominent role in determining the plasma pharmacokinetics and disposition of caspofungin, as very little excretion or biotransformation occurred during the early days after dose administration, a period during which concentrations in plasma fell substantially. The disposition of caspofungin in preclinical species was similar to that reported previously in humans.

The relational-interdependent self-construal, self-concept consistency, and well-being.

Examination of the assumptions underlying consistency perspectives in social and personality psychology reveals that they are based on an independent, individualistic view of the self. If the self is constructed as relational or interdependent with others, consistency may be less important in social behavior and well-being. Using a variety of measures of well-being, the studies showed that there is a weaker relation between consistency and well-being for individuals with a highly relational self-construal than for those with a low relational self-construal. Study 3 examined the association between the self-construal, consistency, authenticity, and well-being. These findings reveal the importance of a cultural analysis of theories of the self, personality, and well-being for further theory development.

Getting to know you: the relational self-construal, relational cognition, and well-being.

Individuals with a highly relational self-construal define the self in terms of their close relationships with others. Consequently, they seek to nurture and develop new relationships. These studies examine individual differences in the self-construal in the context of a new roommate relationship, with a focus on cognitive aspects of relationship development. Study 1 revealed that persons with a highly relational self-construal were better able than others to predict a new roommate's values and beliefs. Study 2 showed that highly relational individuals tended to think optimistically about a new roommate's feelings about the relationship. The relational self-construal was more strongly related to these measures of relationship cognition in distant relationships than in very close relationships. Participants' self-construals and their perceptions of the closeness of the roommate relationship interacted in predicting well-being, revealing an unexpected negative relation between closeness and well-being for participants with a low relational self-construal.

Thinking about oneself and others: the relational-interdependent self-construal and social cognition.

These studies focus on the relational-interdependent self-construal's association with implicit or indirect cognitive processes. In the relational-interdependent self-construal, the self is defined largely in terms of close relationships, resulting in variation in self-related processes. In Studies 1 and 2, the relational self-construal was associated with positive implicit evaluations of relational concepts and with tightly organized cognitive networks of relational terms. Studies 3 and 4 demonstrated that this self-construal was associated with memory for and implicit organization of relational information. In Studies 5 and 6, the relational self-construal was positively related to the degree to which participants described themselves and a friend similarly. The implications of the relational self-construal for theories of relationship cognition and for other self-related cognitive processes are discussed.