1.
J Med Primatol
; 51(5): 284-287, 2022 10.
Article
in English
| MEDLINE
| ID: mdl-36030392
ABSTRACT
Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross-species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4+ T cell decline and increases in plasma viral loads.
Subject(s)
Rodent Diseases , Simian Acquired Immunodeficiency Syndrome , Simian Immunodeficiency Virus , Animals , Humans , Macaca mulatta , Mice , Serial Passage , Simian Immunodeficiency Virus/genetics , Viral Load
2.
J Med Primatol
; 51(5): 288-291, 2022 10.
Article
in English
| MEDLINE
| ID: mdl-36030391
ABSTRACT
Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV-1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV-1 Group M over the course of four generations. Higher initial viral load, increased CD4+ T-cell decline, and nonsynonymous substitutions arose suggesting viral evolution.
