1.
Bioorg Med Chem Lett
; 8(7): 725-30, 1998 Apr 07.
Article
in English
| MEDLINE
| ID: mdl-9871530
ABSTRACT
A series of novel, potent and selective pyrido[1,2-a]pyrazine dopamine D4 receptor antagonists are reported including CP-293,019 (D4 Ki = 3.4 nM, D2 Ki > 3,310 nM), which also inhibits apomorphine-induced hyperlocomotion in rats after oral dosing.
Subject(s)
Dopamine Antagonists/chemical synthesis , Dopamine D2 Receptor Antagonists , Motor Activity/drug effects , Pyrazines/chemical synthesis , Pyrimidines/chemical synthesis , Animals , Apomorphine/pharmacology , Dopamine Antagonists/chemistry , Dopamine Antagonists/pharmacology , Drug Design , Haloperidol/pharmacology , Indicators and Reagents , Molecular Structure , Pyrazines/chemistry , Pyrazines/pharmacology , Pyrimidines/chemistry , Pyrimidines/pharmacology , Rats , Receptors, Dopamine D4 , Structure-Activity Relationship
2.
J Med Chem
; 35(23): 4503-5, 1992 Nov 13.
Article
in English
| MEDLINE
| ID: mdl-1447752