ABSTRACT
BACKGROUND: Beyond the typical respiratory symptoms associated with novel coronavirus, increasing evidence has been reported of the neurological manifestations affecting both the central and peripheral nervous systems. CASE PRESENTATION: We observed a 30-year-old Persian woman developing acute motor sensory axonal neuropathy, a variant of Guillain-Barré syndrome that overlaps Miller Fisher syndrome, 30 days after confirmed coronavirus disease-2019 infection. Our case highlight the rare occurrence of Guillain-Barré syndrome overlapping with Miller Fisher during the coronavirus disease-2019 pandemic. These neurologic manifestations may occur because of an aberrant immune response to coronavirus disease-2019. CONCLUSIONS: The early recognition of Guillain-Barré syndrome symptoms is critical, given the associated severe motor disabilities that may seriously limit the quality of life of these patients. We may still have much to learn about the co-occurrence of Guillain-Barré syndrome and Miller Fisher to improve the quality of life of these patients requiring an accurate evaluation by neurologists.
Subject(s)
COVID-19 , Guillain-Barre Syndrome , Miller Fisher Syndrome , Adult , Female , Guillain-Barre Syndrome/diagnosis , Humans , Miller Fisher Syndrome/complications , Miller Fisher Syndrome/diagnosis , Quality of Life , SARS-CoV-2ABSTRACT
Physical rehabilitation aims people with physical impairments to enhance and restore their functional ability. The Microsoft Kinect v1 and v2 technologies apply depth information and machine vision techniques to generate 3D coordinates of a set of anatomical landmarks on the human body regarded as Kinect joints. Trigonometry relationship between Kinect joints can be used to extract body Range of Motion (ROM). The purpose of this study was to evaluate stability of Kinect for ROM measurement during static stretching exercises. According to the literature, the stability of Kinect in static exercises has been reported to a limited extent. 13 healthy men participated in this study and performed 5 exercises in 2 different distances from the cameras. Exercises were recorded by Kinect v1 and Kinect v2, concurrently. The stability of Kinect was also evaluated for 5 ROMs including: elbow flexion, shoulder abduction, wrist pronation, wrist flexion, and wrist ulnar deviation. Maximum and average joint displacement errors were used for stability analysis. Results showed that Kinect v2 is more stable compared to Kinect v1. Kinect v2 joints showed displacement error of more than 15 mm for wrist. For the other joints, Kinect showed an average displacement error of less than 10 mm.
Subject(s)
Joints/physiology , Muscle Stretching Exercises , Range of Motion, Articular , Adult , Female , Humans , Male , Software , Young AdultABSTRACT
BACKGROUND: Tissue engineering is used for the treatment of many diseases, and the ideal cell source for cartilage tissue engineering is chondrocytes. The main limitation of chondrocyte is the low number of cells in cartilage tissue engineering. This study investigated a suitable cell source with high proliferation rate to obtain a large number of chondrocytes. METHODS: Adult cartilage tissue samples were obtained from adult patients undergoing surgical procedure, and infant cartilage tissue samples were obtained from polydactyly surgical waste. After isolation and expansion of chondrocytes, the proliferation rate was evaluated by calculating population doubling time (PDT) and MTT assay for both types of cells. Cartilage film was prepared with sheets of over confluent chondrocytes. The cartilage tissue film from infant and adult chondrocytes were evaluated histologically and by immunefluorescent staining collagen type 2. RESULTS: PDT and MTT assays revealed that the growth rate of the infant chondrocytes was significantly higher than adult chondrocytes. Histological findings showed that sheets were thicker in the cartilage film of infant chondrocytes and they had more extracellular matrix between the sheets of cells than the cartilage film of adult chondrocytes. The findings of the immunofluorescent staining of cartilage film indicated that collagen type II film of polyductily was more positive than adult chondrocytes. CONCLUSION: The recent study presented a new cell source to overcome the limitation of low number of chondrocytes for cell therapy of cartilage defects in adults and also sheets of cells able to overcome the problems of scaffolds.
