ABSTRACT
Fourteen of 52 unselected patients with systemic lupus erythematosus (SLE) (27%) had ligamentous derangement demonstrated by either Jaccoud's syndrome and/or patellar tendon elongation. Three cases had only Jaccoud's syndrome, 4 isolated patellar tendinous laxity, while the remaining 7 presented both findings. Jaccoud's syndrome and/or tendinous laxity were not associated to an increased frequency of arthritis, corticosteroid therapy or a longer disease duration, but significantly associated with increased serum PTH levels secondary to chronic renal failure. Hyperparathyroidism secondary to chronic renal failure should, therefore, be considered a potential factor contributing to the development of Jaccoud's syndrome and/or tendinous laxity in patients with SLE.
Subject(s)
Arthritis/physiopathology , Hyperparathyroidism, Secondary/physiopathology , Joint Instability/physiopathology , Lupus Erythematosus, Systemic/physiopathology , Tendons/physiopathology , Adolescent , Adult , Calcium/blood , Child , Creatinine/urine , Female , Foot Deformities, Congenital , Hand Deformities, Congenital , Humans , Knee Joint/physiopathology , Male , Middle Aged , Parathyroid Hormone/blood , Phosphorus/blood , Uric Acid/bloodABSTRACT
We describe a patient with systemic lupus erythematosus, chronic renal failure and secondary hyperparathyroidism who developed laxity and elongation of the patellar tendon, followed by its rupture one year later. Hydroxyapatite and urate crystals were identified from the chalky material surrounding the patellar tendon observed at surgery. These findings suggest that tendon laxity and elongation could possibly be detected before its rupture and that secondary hyperparathyroidism could be considered as another causative factor of tendon damage in patients with systemic lupus erythematosus.
Subject(s)
Hyperparathyroidism, Secondary/complications , Knee , Lupus Erythematosus, Systemic/complications , Tendon Injuries/etiology , Adult , Chronic Disease , Female , Humans , Hyperparathyroidism, Secondary/etiology , Kidney Diseases/complications , Knee/diagnostic imaging , Radiography , Rupture, Spontaneous , Tendon Injuries/diagnostic imaging , Tendon Injuries/pathology , Tendons/diagnostic imaging , Tendons/pathologyABSTRACT
En el presente trabajo se analizan los hallazgos obtenidos con la determinacion de los antigenos H.L.A. en relacion a distintas enfermedades en Medicina Interna. Se presentan los datos observados de frecuencia fenotipica y genotipica en la poblacion normal y su distribucion en los loci A, B, C y DR. En cuanto al estudio de asociaciones patologicas se analiza la frecuencia de los antigenos de histocompatibilidad en la artritis reumatoidea juvenil espondilitis anquilisante y artritis psoriasica. En relacion a enfermedades endocrinometabolicas han sido analizados pacientes con diabetes mellitus insulinodependientes y un grupo de pacientes con hipertiroidismo. Finalmente se analizan los hallazgos observados en enfermedad celiaca y en portadores cronicos asintomaticos del antigeno de superficie de la hepatitis viral tipo B
Subject(s)
Humans , Gene Frequency , HLA AntigensABSTRACT
En el presente trabajo se analizan los hallazgos obtenidos con la determinacion de los antigenos H.L.A. en relacion a distintas enfermedades en Medicina Interna. Se presentan los datos observados de frecuencia fenotipica y genotipica en la poblacion normal y su distribucion en los loci A, B, C y DR. En cuanto al estudio de asociaciones patologicas se analiza la frecuencia de los antigenos de histocompatibilidad en la artritis reumatoidea juvenil espondilitis anquilisante y artritis psoriasica. En relacion a enfermedades endocrinometabolicas han sido analizados pacientes con diabetes mellitus insulinodependientes y un grupo de pacientes con hipertiroidismo. Finalmente se analizan los hallazgos observados en enfermedad celiaca y en portadores cronicos asintomaticos del antigeno de superficie de la hepatitis viral tipo B
Subject(s)
Humans , HLA Antigens , Gene FrequencyABSTRACT
Serum amyloid protein (SAA) levels were determined by radioimmunoassay in 90 children with juvenile rheumatoid arthritis (JRA). Significantly higher levels of SAA were present in children with the polyarticular and systemic forms of the disease. SAA levels correlate with disease activity, increasing during acute exacerbations, decreasing during remission and in patients having prednisone therapy. High serum SAA concentrations in children with JRA did not correlate with the presence of secondary amyloidosis and may be useful as a disease monitor.
