1.
J Anal Toxicol
; 27(5): 318-22, 2003.
Article
in English
| MEDLINE
| ID: mdl-12908947
ABSTRACT
We present a fatal case involving the combined ingestion of amphetamine, 3,4-methylenedioxymethylamphetamine, 3,4-methylenedioxyamphetamine, and paramethoxyamphetamine. Various postmortem specimens (e.g., several blood samples, urine, and tissue samples) were analyzed to study the distribution of the compounds and their metabolites in the human body. Quantitation took place using liquid chromatography-sonic spray ionization-mass spectrometry after pretreatment with a liquid-liquid extraction. The medico-legal findings were compatible with a disseminated intravascular coagulation induced by hyperthermia caused by the simultaneous intake of the amphetamine analogues.
Subject(s)
3,4-Methylenedioxyamphetamine/analogs & derivatives , Amphetamine/poisoning , Designer Drugs/poisoning , N-Methyl-3,4-methylenedioxyamphetamine/poisoning , 3,4-Methylenedioxyamphetamine/pharmacokinetics , 3,4-Methylenedioxyamphetamine/poisoning , Adult , Amphetamine/pharmacokinetics , Amphetamines , Autopsy , Chromatography, Liquid/methods , Drug Interactions , Fatal Outcome , Humans , Male , N-Methyl-3,4-methylenedioxyamphetamine/pharmacokinetics , Spectrometry, Mass, Electrospray Ionization/methods , Tissue Distribution
2.
Rapid Commun Mass Spectrom
; 15(18): 1773-5, 2001.
Article
in English
| MEDLINE
| ID: mdl-11555880