Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Molecules ; 19(8): 12011-30, 2014 Aug 12.
Article in English | MEDLINE | ID: mdl-25120054

ABSTRACT

Novel derivatives were prepared by reaction of aromatic amines with 2-(4-ethylphenoxymethyl)benzoyl isothiocyanate, affording the N-[2-(4-ethylphenoxymethyl) benzoyl]-Nꞌ-(substituted phenyl)thiourea. Structural elucidation of these compounds was performed by IR, NMR spectroscopy and elemental analysis. The new compounds were used in combination with Fe3O4 and polyvinylpyrrolidone (PVP) for the coating of medical surfaces. In our experiments, catheter pieces were coated by Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The microbial adherence ability was investigated in 6 multi-well plates by using culture based methods. The obtained surfaces were also assessed for their cytotoxicity with respect to osteoblast cells, by using fluorescence microscopy and MTT assay. The prepared surfaces by advanced laser processing inhibited the adherence and biofilm development ability of Staphylococcus aureus and Pseudomonas aeruginosa tested strains while cytotoxic effects on the 3T3-E1 preosteoblasts embedded in layer shaped alginate hydrogels were not observed. These results suggest that the obtained medical surfaces, based on the novel thiourea derivatives and magnetic nanoparticles with a polymeric shell could represent a promising alternative for the development of new and effective anti-infective strategies.


Subject(s)
Anti-Bacterial Agents/chemistry , Benzamides/chemistry , Biofilms/drug effects , Iron Compounds/chemistry , Polyvinyls/chemistry , Pyrrolidines/chemistry , Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/pharmacology , Benzamides/chemical synthesis , Benzamides/pharmacology , Biofilms/growth & development , Humans , Iron Compounds/pharmacology , Magnetic Resonance Spectroscopy , Nanostructures/administration & dosage , Nanostructures/chemistry , Polyvinyls/chemical synthesis , Polyvinyls/pharmacology , Pseudomonas aeruginosa/drug effects , Pseudomonas aeruginosa/growth & development , Pyrrolidines/chemical synthesis , Pyrrolidines/pharmacology , Staphylococcus aureus/drug effects , Staphylococcus aureus/growth & development
SELECTION OF CITATIONS
SEARCH DETAIL
...