Subject(s)
Graft Rejection/physiopathology , Kidney Transplantation/physiology , Postpartum Period , Pregnancy Complications , Adult , Blood Transfusion , Chronic Disease , Creatinine/blood , Female , Graft Rejection/epidemiology , Histocompatibility Testing , Humans , Kidney Transplantation/immunology , Postoperative Complications/epidemiology , Pregnancy , ProteinuriaABSTRACT
Forty nine children with hepatitis B virus-mediated glomerulonephritis (GN) were observed during the last 11 years. Boys were more frequently affected than girls, the ratio being 38 : 11. Young infants (1 to 5 years of age) predominated in the group. The incidence of membranous form of glomerulonephritis was high (34 out of 44 kidney biopsy cases, 77%), the rest of patients showing mesangiocapillary GN-8 (18%) and mesangial proliferative GN-2 (5%). The disease proved to be self limiting. Immunosuppressive or indomethacin treatment did not modify the course and outcome of the disease. Liver disease in these patients often persisted after the resolution of glomerulonephritis.
Subject(s)
Glomerulonephritis/etiology , Hepatitis B/complications , Child , Child, Preschool , Female , Glomerulonephritis/pathology , Hematuria/etiology , Hepatitis B/pathology , Humans , Infant , Kidney/pathology , Male , Nephrotic Syndrome/etiology , Proteinuria/etiologySubject(s)
Glomerulonephritis/pathology , Kidney Transplantation , Adolescent , Adult , Biopsy , Child , Female , Glomerulonephritis/etiology , Glomerulosclerosis, Focal Segmental/pathology , Humans , Immunoglobulins/analysis , Kidney/immunology , Kidney/pathology , Male , Microscopy, Electron , Middle Aged , Nephrectomy , RecurrenceABSTRACT
Kidney tissue from 99 unselected necropsy cases of various forms of hepatitis and liver cirrhosis was examined by histology and direct immunofluorescence. Glomerular deposits of hepatitis B surface antigen (HBsAg), IgG, IgM, and complement were found in nine of 59 cases (15%) of acute and subacute hepatitis and in seven of 40 cases (17%) of chronic aggressive hepatitis and liver cirrhosis. Different amounts of granular hepatitis B surface antigen immune deposits were distributed along glomerular capillary walls and/or in mesangial areas. Glomerular lesions found in these cases consisted of thickening of glomerular capillary walls, a slight increase in glomerular cellularity, and an increase of mesangial matrix. These glomerular lesions are considered to result from the humoral immune elimination of circulating viral surface antigen immune complexes.
Subject(s)
Hepatitis B/pathology , Kidney Glomerulus/pathology , Complement C3/analysis , Fluorescent Antibody Technique , Hepatitis B/immunology , Hepatitis B Core Antigens/analysis , Hepatitis B Surface Antigens/analysis , Humans , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Kidney Glomerulus/immunology , Liver/immunology , Liver Cirrhosis/immunology , Liver Cirrhosis/pathology , Spleen/immunologyABSTRACT
The present studies were undertaken to characterize cytotoxic activity of lymphocyte-(ADCC) in the course of primary glomerulonephritis and to evaluate the influence of some of the immunosuppressive drugs on lymphocytes of examined patients. 18 patients were studied; 12 of them were treated by combined therapy with prednisone, azathioprine and chlorambucil. Results were analyzed on the basis of healthy individuals ADCC activity. In the 11 treated patients significant decrease of ADCC activity was observed while non-treated group exhibited as high activity as healthy individuals. Which of given drugs is responsible for the decreased ADCC activity, remains questionable and is currently under the study.
