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Iran J Immunol ; 9(2): 109-19, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22735798

ABSTRACT

BACKGROUND: Malassezia furfur is a lipophilic yeast that causes skin disease. OBJECTIVE: To evaluate the level of IL-10, IFN-γ and IL-12P70 in co-incubation of peripheral blood mononuclear cells (PBMCs) with M. furfur grown in the presence of some different types of natural oils. METHODS: PBMCs were obtained from blood samples of normal volunteers. M. furfur was cultured in different culture media containing almond oil, fish oil, walnut oil, full-fat milk, and a fat-free medium; and the yeasts grown were harvested and used for co-incubation with PBMCs in vitro. The IFN-γ, IL-10, and IL-12P70 levels were measured at different time intervals using ELISA methods. RESULTS: Generally, IFN-γ and IL-10 levels in the co-incubation of yeasts with walnut oil group (WOG) and fish oil group (FOG) were higher than those in the almond oil group (AOG) and full-fat milk group (FFMG). Although the IL-12P70 was higher in groups such as AOG, FOG, and WOG; the increase was not statistically significant. CONCLUSION: The results demonstrated that the type of fat used by M. furfur in the culture media can influence the immune response and increasesIFN-γ and IL-10 levels in an early time point of the culture system.


Subject(s)
Leukocytes, Mononuclear/drug effects , Malassezia/immunology , Tinea Versicolor/immunology , Animals , Cattle , Cells, Cultured , Cytokines/metabolism , Fish Oils/pharmacology , Fishes/immunology , Humans , Juglans/immunology , Leukocytes, Mononuclear/immunology , Lymphocyte Activation/drug effects , Milk/metabolism , Plant Oils/pharmacology
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