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1.
Med Oral Patol Oral Cir Bucal ; 24(5): e643-e651, 2019 Sep 01.
Article in English | MEDLINE | ID: mdl-31422410

ABSTRACT

BACKGROUND: To evaluate the changes in the peri-implant soft tissues of convergent collar implants with biologically oriented preparation technique (BOPT) crowns, 10 months after loading. MATERIAL AND METHODS: A pilot study was carried out from January 2016 to October 2017 involving 14 patients with one or two implants in the posterior mandibular sector. A total of 32 convergent collar implants were placed using a non-submerged protocol. Three months later the provisional cemented crowns were fitted using the BOPT approach with the finish line 1-1.5 mm below the gingival margin, simulating coronal emergence of a natural tooth. The soft tissue changes were measured with an intraoral scanner at two different timepoints: a) on the day of provisionalization, before prosthetic loading; and b) 10 months later without the provisional prosthesis. The STL files were superimposed and the soft tissue changes were recorded using a color scale with measurement of the volumetric changes in mm3. RESULTS: A mean increase in peri-implant mucosal volume of 64.7 mm3 was observed in 29 implants. The zones with the greatest increase in soft tissue volume were the papillae of implants with adjacent teeth and the peri-implant buccal margin. Three implants showed a mean decrease in soft tissue volume of -25.1 mm3. CONCLUSIONS: The fitting and design of crowns using the biologically oriented preparation technique (BOPT) over convergent collar implants affords a significant increase in peri-implant soft tissue volume both at the level of the papillae and in the buccal margin.


Subject(s)
Dental Implants, Single-Tooth , Immediate Dental Implant Loading , Crowns , Dental Implantation, Endosseous , Dental Prosthesis, Implant-Supported , Humans , Pilot Projects , Tooth Extraction , Treatment Outcome
2.
Eur J Dent Educ ; 22(1): e48-e56, 2018 Feb.
Article in English | MEDLINE | ID: mdl-28295943

ABSTRACT

INTRODUCTION: Failure to adopt a correct working posture can lead to occupational diseases. OBJECTIVES: Evaluate knowledge in relation to ergonomics about BHOP concept and its application to routine clinical practice amongst undergraduate and postgraduate dental students in the University of Valencia (Valencia, Spain). MATERIAL AND METHODS: A study based on interviews of undergraduate and postgraduate dental students in the University of Valencia (Valencia, Spain) was carried out. The information from a total of 336 interviews was used for the statistical analysis, differentiating according to gender and academic year: knowledge of ergonomics, pain prevalence and antecedents, assessment of the possible necessity for improved training in ergonomics, and evaluation of postural hygiene. RESULTS: Only 28.6% of the students were found to sit correctly in the dentist chair. Furthermore, in the opinion of the students, very few subjects during the career afforded adequate teaching in relation to ergonomics and working posture. The analysis of postural hygiene showed great variability. There were no significant differences in posture between males and females, although some incorrect postures appeared to be associated with the academic year (P<.05). However, no significant improvements in postural hygiene were noted on progressing from one academic year to the next. CONCLUSIONS: The students in our study were not familiar with the principles of ergonomics and did not sit correctly in the dentist chair. Improved training in this field is required in dental school.


Subject(s)
Ergonomics , Posture , Students, Dental , Female , Humans , Male , Self Report , Spain , Universities , Young Adult
3.
J Thromb Haemost ; 13(7): 1335-44, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25960087

ABSTRACT

BACKGROUND: Histone deacetylases (HDACs) play a key role in signaling in many cell types. However, little is known about the participation of HDACs, particularly sirtuins (SIRTs), in platelet reactivity. OBJECTIVE: To investigate the role of HDACs in platelets, we examined the effects of SIRT inhibition on platelet function and protein acetylation in human platelets. METHODS: We used washed platelets obtained from healthy subjects. Cambinol (SIRT1 and SIRT2 inhibitor), AGK2 (specific SIRT2 inhibitor) and EX527 (specific SIRT1 inhibitor) were used as SIRT inhibitors. Platelets were stimulated with collagen, thrombin, or U46619, and platelet responses were determined according to optical aggregometry findings, dense granule release, and cytosolic calcium levels (Fura-2AM fluorescence). Protein acetylation and phosphorylation were assessed by immunoblotting. RESULTS: SIRT inhibition remarkably reduced platelet responses (aggregation, granule release, and cytosolic calcium level; P < 0.05). SIRT2 was present in platelets at the level of mRNA and protein, and its specific inhibition reduced platelet responses. The acetylated protein pattern observed in resting platelets changed during platelet aggregation. Inhibition of SIRT2 increased the acetylation of Akt kinase, which in turn blocked agonist-induced Akt phosphorylation and glycogen synthase kinase-3ß phosphorylation, which are markers of Akt activity. Finally, collagen-induced aggregation provoked Akt acetylation. CONCLUSIONS: Regulation of protein acetylation by SIRT2 plays a central role in platelet function. The effects of SIRT2 are mediated in part by the acetylation and inhibition of Akt. These results open a new avenue for research into the control of platelet function, and may help to identify new therapeutic targets.


Subject(s)
Blood Platelets/enzymology , Protein Processing, Post-Translational , Sirtuin 2/blood , Acetylation , Blood Platelets/drug effects , Blood Platelets/metabolism , Calcium/blood , Cytoplasmic Granules/enzymology , Cytoplasmic Granules/metabolism , Glycogen Synthase Kinase 3/blood , Glycogen Synthase Kinase 3 beta , Histone Deacetylase Inhibitors/pharmacology , Humans , Phosphorylation , Platelet Aggregation , Platelet Aggregation Inhibitors/pharmacology , Protein Processing, Post-Translational/drug effects , Proto-Oncogene Proteins c-akt/blood , RNA, Messenger/blood , Secretory Vesicles/enzymology , Secretory Vesicles/metabolism , Signal Transduction , Sirtuin 2/antagonists & inhibitors , Sirtuin 2/genetics
4.
FEBS Lett ; 588(17): 3154-9, 2014 Aug 25.
Article in English | MEDLINE | ID: mdl-24996187

ABSTRACT

We have investigated the presence of thromboxane A2 (TXA2) receptor associated with lipid rafts in human platelets and the regulation of platelet function in response to TXA2 receptor agonists when lipid rafts are disrupted by cholesterol extraction. Platelet aggregation with TXA2 analogs U46619 and IBOP was almost blunted in cholesterol-depleted platelets, as well as αIIbß3 integrin activation and P-selectin exposure. Raft disruption also inhibited TXA2-induced cytosolic calcium increase and nucleotide release, ruling out an implication of P2Y12 receptor. An important proportion of TXA2 receptor (40%) was colocalized at lipid rafts. The presence of the TXA2 receptor associated with lipid rafts in platelets is important for functional platelet responses to TXA2.


Subject(s)
Blood Platelets/cytology , Blood Platelets/physiology , Membrane Microdomains/metabolism , Receptors, Thromboxane A2, Prostaglandin H2/metabolism , Blood Platelets/drug effects , Calcium/metabolism , Cytosol/drug effects , Cytosol/metabolism , Humans , Membrane Microdomains/drug effects , Platelet Activation/drug effects , Thromboxane A2/pharmacology
5.
Actas dermo-sifiliogr. (Ed. impr.) ; 102(8): 605-615, oct. 2011.
Article in Spanish | IBECS | ID: ibc-92563

ABSTRACT

Introducción: El queratoacantoma es considerado hoy día un carcinoma epidermoide in situ que aparece principalmente en pacientes mayores de 70 años. Se trata de un tumor de buen pronóstico que, en algunos casos, muestra resolución espontánea.El tratamiento de este tipo de tumoración es la exéresis simple. Sin embargo, la localización preferente en las regiones facial y acral, el tamaño y su rápido crecimiento son factores que hacen que la cirugía sea en algunos casos agresiva y antiestética. Objetivo: El objetivo principal del estudio es evaluar la eficacia de la infiltración intralesional de metotrexato en la reducción del tamaño prequirúrgico de la lesión y del correspondiente defecto quirúrgico resultante de la intervención. Material y métodos: Se realizó un estudio prospectivo aleatorizado en el que se incluyeron todos aquellos pacientes atendidos en nuestro Servicio diagnosticados de queratoacantoma de al menos 1,5cm de tamaño entre enero de 2009 y enero de 2010. Se establecieron dos grupos, uno en el que los pacientes recibieron una infiltración de metotrexato previamente al acto quirúrgico y otro en el que se realizó directamente la cirugía. Resultados: De los 25 pacientes incluidos en el estudio, 10 casos recibieron neoadyuvancia con metotrexato intralesional (grupo A) y 15 casos fueron intervenidos mediante cirugía aislada (grupo B).Los pacientes del grupo A mostraron una reducción en el tamaño tumoral en el momento de la cirugía que osciló entre un 50 y un 80%. Ninguno de los pacientes presentó complicaciones relacionadas con la inoculación del metotrexato ni con la intervención quirúrgica. En el grupo B sólo uno de los casos mostró una discreta disminución de sus dimensiones en el momento del acto quirúrgico. El resto de las lesiones mostraron una estabilidad (4 casos; 26%) e incluso un aumento de las dimensiones del tumor (10 casos; 66%) en el momento de la intervención. Cinco de los casos incluidos en este último grupo requirieron ingreso hospitalario en relación con la intervención quirúrgica. Conclusiones: El metotrexato intralesional como terapia neoadyuvante es una medida bien tolerada, que permite evitar cirugías agresivas en pacientes de edades avanzadas que presentan un queratoacantoma de diámetro superior a 1,5cm localizado en la región facial y acral (AU)


Background: Keratoacanthoma is currently considered to be an in situ squamous cell carcinoma that mainly affects patients over 70 years of age. The tumor has a good prognosis and, in some cases, can resolve spontaneously. Treatment involves simple excision. However, since the tumors generally occur on the face or extremities and display rapid growth, aggressive surgery may be required and the cosmetic results may be poor. Objective: The primary study objective was assessment of the efficacy of presurgical intralesional methotrexate infiltration to reduce the size of the tumor and the corresponding surgical defect. Material and methods: A prospective, randomized study was undertaken in patients with a diagnosis of keratoacanthoma of at least 1.5cm who were seen in our service between January 2009 and January 2010. Two groups were established: one receiving a single infiltration of methotrexate prior to surgery and another that did not receive methotrexate. Results: Of the 25 patients included in the study, 10 received neoadjuvant intralesional methotrexate (group A) and 15 underwent surgery without prior infiltration of methotrexate (group B). The patients in group A displayed a reduction of between 50% and 80% in the size of the lesion prior to surgery. No complications were observed either in relation to methotrexate infusion or surgery. In group B, only 1 patient had a slight reduction in the dimensions of the lesion prior to surgery. In the remaining cases, the lesions remained similar (4 cases, 26%) or had increased in size (10 cases, 66%) at the time of surgery. Five patients in this group required hospital admission following surgery. Conclusions: Neoadjuvant intralesional methotrexate is well tolerated and reduces the need for aggressive surgery in elderly patients with keratoacanthoma measuring more than 1.5cm on the face or extremities (AU)


Subject(s)
Humans , Male , Female , Methotrexate/therapeutic use , Keratoacanthoma/diagnosis , Keratoacanthoma/drug therapy , Keratoacanthoma/surgery , Infusions, Intralesional/trends , Neoadjuvant Therapy/trends , Randomized Controlled Trials as Topic , Methotrexate/administration & dosage , Keratoacanthoma/pathology , Infusions, Intralesional/methods
6.
Actas Dermosifiliogr ; 102(8): 605-15, 2011 Oct.
Article in Spanish | MEDLINE | ID: mdl-21742301

ABSTRACT

BACKGROUND: Keratoacanthoma is currently considered to be an in situ squamous cell carcinoma that mainly affects patients over 70 years of age. The tumor has a good prognosis and, in some cases, can resolve spontaneously. Treatment involves simple excision. However, since the tumors generally occur on the face or extremities and display rapid growth, aggressive surgery may be required and the cosmetic results may be poor. OBJECTIVE: The primary study objective was assessment of the efficacy of presurgical intralesional methotrexate infiltration to reduce the size of the tumor and the corresponding surgical defect. MATERIAL AND METHODS: A prospective, randomized study was undertaken in patients with a diagnosis of keratoacanthoma of at least 1.5 cm who were seen in our service between January 2009 and January 2010. Two groups were established: one receiving a single infiltration of methotrexate prior to surgery and another that did not receive methotrexate. RESULTS: Of the 25 patients included in the study, 10 received neoadjuvant intralesional methotrexate (group A) and 15 underwent surgery without prior infiltration of methotrexate (group B). The patients in group A displayed a reduction of between 50% and 80% in the size of the lesion prior to surgery. No complications were observed either in relation to methotrexate infusion or surgery. In group B, only 1 patient had a slight reduction in the dimensions of the lesion prior to surgery. In the remaining cases, the lesions remained similar (4 cases, 26%) or had increased in size (10 cases, 66%) at the time of surgery. Five patients in this group required hospital admission following surgery. CONCLUSIONS: Neoadjuvant intralesional methotrexate is well tolerated and reduces the need for aggressive surgery in elderly patients with keratoacanthoma measuring more than 1.5 cm on the face or extremities.


Subject(s)
Antimetabolites, Antineoplastic/therapeutic use , Keratoacanthoma/drug therapy , Methotrexate/therapeutic use , Neoadjuvant Therapy , Skin Neoplasms/drug therapy , Aged , Aged, 80 and over , Antimetabolites, Antineoplastic/administration & dosage , Combined Modality Therapy , Double-Blind Method , Esthetics , Facial Neoplasms/drug therapy , Facial Neoplasms/pathology , Facial Neoplasms/surgery , Female , Hand , Humans , Injections, Intralesional , Keratoacanthoma/pathology , Keratoacanthoma/surgery , Male , Methotrexate/administration & dosage , Middle Aged , Prospective Studies , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Treatment Outcome , Tumor Burden
7.
J Thromb Haemost ; 6(4): 615-21, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18221358

ABSTRACT

BACKGROUND: Permanent inactivation of cyclooxygenase-1 and inhibition of platelet thromboxane A(2) (TxA(2)) constitute the main mechanisms underlying the prevention of vascular disease by aspirin. METHODS AND RESULTS: We studied platelet TxA(2) synthesis and its impact on platelet reactivity and platelet-erythrocyte [platelet-rich plasma (PRP)-RBC] interactions in 533 aspirin-treated patients with vascular disease. Seventy aspirin-free and 16 aspirin-treated normal subjects were evaluated as controls. Collagen (1 mug mL(-1))-induced platelet activation ((14)C-5HT release) and recruitment (proaggregatory activity of cell-free releasates from activated platelets) were assessed in PRP, PRP + RBC, and whole blood (WB). TxA(2) was quantified in releasates from WB. Aspirin inhibited TxA(2) synthesis and platelet function in all patients, but to different degrees. Forty-two patients (8%) displayed partial (<95%) inhibition of TxA(2) relative to that of aspirin-free controls. They produced >3.5 ng mL(-1) TxA(2) and had higher platelet reactivity than 491 patients who had undetectable TxA(2) or produced residual TxA(2) (R-TxA(2);

Subject(s)
Aspirin/therapeutic use , Blood Platelets/chemistry , Cyclooxygenase Inhibitors/therapeutic use , Erythrocytes/physiology , Thromboxane A2/blood , Vascular Diseases/blood , Aged , Aspirin/pharmacology , Collagen/pharmacology , Cyclooxygenase 1/blood , Cyclooxygenase Inhibitors/pharmacology , Drug Resistance/physiology , Female , Humans , Male , Middle Aged , Platelet Activation/drug effects , Platelet Aggregation/drug effects , Platelet-Rich Plasma , Serotonin/metabolism , Thromboxane A2/biosynthesis , Vascular Diseases/drug therapy
8.
An. psiquiatr ; 19(8): 337-342, sept. 2003. ilus, tab
Article in Es | IBECS | ID: ibc-28386

ABSTRACT

En este artículo analizamos la posible relación entre determinados rasgos de personalidad y la profesión médica o sus distintas especialidades. En concreto, intentamos determinar la existencia de unos determinados perfiles de personalidad en los estudiantes que se sienten atraídos por cada especialidad médica. El estudio se realizó aplicando el 16 PF de Cattell. Los resultados obtenidos apuntan a la relación de ciertos rasgos de la personalidad con la preferencia por ciertas especialidades. Así, los estudiantes que habían optado por las especialidades de "Pediatría", "Ginecología" y "especialidades sensoriales" tendieron a ser respecto al resto de estudiantes más "afectuosos" (A+), "confiados" (L-) y "prácticos" (M-); los que escogieron la especialidad de "Psiquiatría" fueron más "sensibles" (I+) e "imaginativos" (M+) y los que prefirieron "Traumatología" "duros"(I-) y "prácticos"(M-). Los que optaron por las especialidades de "Medicina Interna" y "Cirugía" no presentaron un perfil de personalidad diferenciado del conjunto de estudiantes de Medicina (AU)


Subject(s)
Female , Male , Humans , Students, Medical/psychology , Medicine/trends , Occupations , Pediatrics , Gynecology , Traumatology , Psychiatry , Socioeconomic Survey , Spain , Personality
9.
Actas Esp Psiquiatr ; 31(1): 24-30, 2003.
Article in Spanish | MEDLINE | ID: mdl-12590369

ABSTRACT

OBJECTIVE: In this paper, we try to analyze he possible relationships between gender of the Medical students, their personality and their vocational preferences. MATERIAL AND METHODS: A total of 1,482 2nd year medical students from the Valencia University were analyzed. They answered and anonymous survey on their sociodemographic characteristics and their vocational interests. We determined their personality profile with the 16 PF of Cattell. The data obtained were analyzed with the logistic regression techniques. RESULTS: Most of the population analyzed were female (62.7%) with a medium age of 20 years. The Pediatric and Gynecology-Obstetrics specialities were preferred mostly by female students and Orthopedic surgery by male students. The female students had a specific personality traits, they were more <> (A+), <> (G+), Boldness (H+), <> (n+) and <> (Q3+). While the male students were more <> (I+), <> (L+), <> (M+), <> Q2(+). CONCLUSIONS: Gender has a significant influence on the medical student both in their vocational preferences as well as their personality profile.


Subject(s)
Career Choice , Personality , Students, Medical/psychology , Adult , Female , Humans , Male , Personality Inventory , Sex Factors
10.
Actas esp. psiquiatr ; 31(1): 24-30, ene. 2003.
Article in Es | IBECS | ID: ibc-28855

ABSTRACT

Introducción. En este artículo intentamos analizar las posibles relaciones entre el sexo de los estudiantes de medicina, su personalidad y sus preferencias vocacionales. Material y métodos. Se analizan 1.484 estudiantes de segundo curso de Medicina de la Universidad de Valencia, a los que se les ha realizado una encuesta anónima sobre sus características sociodemográficas, sus intereses vocacionales y su perfil de personalidad mediante el 16 PF de Cattell. Los datos obtenidos se han analizado mediante técnicas de regresión logística. Resultados. La población analizada fue de predominio femenino (62,7 por ciento) y con una edad media de 20 años. Las especialidades de Ginecología y Pediatría fueron preferidas mayoritariamente por las estudiantes de sexo femenino y la de Traumatología por los de sexo masculino. Además las estudiantes de sexo femenino presentan unas características de personalidad diferenciadas, siendo más "afectuosas" (A+), "conscientes" (G+), "emprendedoras" (H+), "astutas" (N+) y "controladas" (Q3+). Mientras que los de sexo masculino fueron más "duros" (I+), "suspicaces" (L+), "prácticos" (M+), "rebeldes" (Q1+) y "autosuficientes" (Q2+).Conclusiones. Los estudiantes de medicina presentan diferencias significativas tanto en su personalidad como en sus preferencias vocacionales según el sexo (AU)


Subject(s)
Adult , Male , Female , Humans , Personality , Career Choice , Students, Medical , Sex Factors , Personality Inventory
11.
An. psiquiatr ; 18(2): 47-53, feb. 2002.
Article in Es | IBECS | ID: ibc-13418

ABSTRACT

En este artículo intentamos determinar la posible existencia de perfiles de personalidad diferenciados en los estudiantes que se sienten atraídos por cada Especialidad Médica frente a una especialidad Quirúrgica. Material y método: Se analizan 1.484 estudiantes de 2º Curso de Medicina de la Universidad de Valencia, a los que se les ha realizado una encuesta anónima sobre sus características sociodemográficas, sus intereses vocacionales y se ha determinado su perfil de personalidad mediante el 16 PF de Cattell. Los datos obtenidos se han analizado mediante técnicas de regresión logística. Resultados: La población analizada fue de predominio femenino (62,7 por ciento) y con una edad media de 20 años. La especialidades Médicas fueron preferidas por un 38,4 por ciento de los estudiantes y las Quirúrgicas por un 39,05 por ciento. El perfil de los estudiantes con mayor tendencia a elegir "Especialidades Quirúrgicas" se caracteriza por ser "impulsivos" (F+) y "duros emocionalmente" (I+); Mientras que los que preferían "Especialidades Médicas" tendían a ser "sensibles emocionalmente" (I-), "confiados" (L-), "astutos" (N+) e "independientes" (QIV+).Conclusiones: Los resultados de nuestro trabajo parecen confirmar la existencia de unos rasgos de personalidad diferentes en los estudiantes que prefieren una "Especialidades Quirúrgica" frente a una "Especialidad Médica" (AU)


Subject(s)
Adult , Female , Male , Humans , Students, Medical/psychology , Personality Assessment , Specialties, Surgical , Choice Behavior , Logistic Models
12.
Actas Esp Psiquiatr ; 29(6): 396-402, 2001.
Article in Spanish | MEDLINE | ID: mdl-11730578

ABSTRACT

UNLABELLED: The vocational indefinition has been related by different authors with higher levels of personal immaturity, dependency sentiments or anxiety. In this paper, we analyses the possible rapport between specific personality traits and the vocational definition in the Medical Students. MATERIAL AND METHOD: It has been analyses 1484 students of 2nd year of Medicine in the Valencia University. They have responded an anonymous interview about their characteristic sociodemographics and their vocational interests. We determinate their Personality Profile with the 16 P.F. of Cattell. The done got has been analysed with Techniques of Regression Logistic. RESULTS AND CONCLUSIONS: The majority of the analysed population were female (62,7%) and with a medium age of 20 years. The majority of the students have definite vocationally in the 2nd year of Medicine: the 81% against the 19%. The students who haven't defined vocationally trend to be more unstable (C-), expedient (G-), strong minded (I-) and shrewd (N+). CONCLUSIONS: The results of our study seems to confirm the association between the career indecision in the Medical Students and specifics traits of personality, particularly the traits associated with the immaturity personal.


Subject(s)
Health Occupations , Personality , Students, Medical/psychology , Adult , Female , Humans , Male , Personality Inventory
13.
Actas esp. psiquiatr ; 29(6): 396-402, nov. 2001. tab, graf
Article in Es | IBECS | ID: ibc-918

ABSTRACT

La falta de definición vocacional se ha relacionado por distintos autores con una mayor inmadurez, sentimientos de dependencia o niveles de ansiedad. En este articulo analizamos la posible relación entre la definición vocacional y los rasgos de personalidad en los estudiantes de Medicina. Material y método: Se analizan 1.484 estudiantes de segundo curso de Medicina de la Universidad de Valencia. Se ha realizado una encuesta anónima sobre sus características sociodemográficas y sus intereses vocacionales. Se ha determinado su perfil de personalidad mediante el 16 PF de Cattell. Los datos obtenidos se han analizado mediante técnicas de regresión logística. Resultados: La población analizada fue de predominio femenino (62,7 por ciento) con una edad media de 20 años. La mayor parte de los estudiantes se había definido vocacionalmente en segundo curso de Medicina: el 81 por ciento frente al 19 por ciento. Los estudiantes que 'no se han definido vocacionalmente' en segundo curso de Medicina tienden a ser más 'inestables emocionalmente' (C-), 'despreocupados' (G-), 'duros, poco predispuestos a ilusionarse' (I-) y 'astutos' (N+).Conclusiones: Los resultados de nuestro estudio parecen confirmar la asociación de la 'indefinición vocacional' en los estudiantes de Medicina con algunos rasgos de personalidad, sobre todo los relacionados con una mayor inmadurez personal (AU)


Subject(s)
Humans , Vocational Education , Students, Medical , Personality , Data Collection
14.
An. psiquiatr ; 17(1): 1-7, ene. 2001. tab, graf
Article in Es | IBECS | ID: ibc-1563

ABSTRACT

En este artículo intentamos analizar la posible relación entre determinados rasgos de personalidad y el retraso académico en los estudiantes de Medicina. Material y método: Se han analizado 1.369 estudiantes de segundo curso a los que se les ha administrado el 16 PF de Cattell para determinar su perfil de personalidad. Se ha utilizado la edad de los estudiantes para valorar su retraso académico. Los datos obtenidos han sido analizados aplicando una t de Student. Resultados: La población analizada fue de predominio femenino (63,7 por ciento) y con una edad media de 19,6 años. Los estudiantes con retraso académico fueron significativamente más "graves" (F-); "sensibles emocionalmente" (I+) y "seguros de sí mismos" (O-). Sin embargo estos resultados fueron de escasa magnitud. Conclusiones: A pesar de las diferencias encontradas entre los estudiantes con o sin retraso académico; pensamos que por las características del 16 PF éstas no son suficientemente discriminantes (AU)


Subject(s)
Adult , Female , Male , Humans , Students, Medical , Personality Assessment , Underachievement , Personality Tests/statistics & numerical data , Pilot Projects , Prevalence , Spain/epidemiology
15.
Actas esp. psiquiatr ; 29(1): 14-18, ene. 2001.
Article in Es | IBECS | ID: ibc-1443

ABSTRACT

Introducción: En este artículo analizamos la posible relación entre determinados rasgos de personalidad y la especialidad de Psiquiatría, intentando determinar la existencia de un determinado perfil de personalidad en los estudiantes que se sienten atraídos por esta especialidad. Material y método: Se analizan 1484 estudiantes de segundo curso de Medicina de la Universidad de Valencia, a los que se les ha realizado una encuesta anónima sobre sus características sociodemográficas y sus intereses vocacionales. Se ha determinado su perfil de personalidad mediante el 16 PF de Cattell. Los datos obtenidos se han analizado mediante una t de Student. Resultados y conclusiones: La población analizada fue de predominio femenino (62,7 por ciento) y con una edad media de 20 años. La especialidad de 'Psiquiatría' fue elegida por el 8,06 por ciento de los estudiantes. Estos estudiantes tendieron a ser con respecto al resto de estudiantes 'sensibles, inmaduros emocionalmente, inseguros' (I+) e 'inestables, impulsivos, desordenados' (Q3-). La revisión bibliográfica consultada parece confirmar esta tendencia (AU)


Subject(s)
Adult , Male , Female , Humans , Personality , Psychiatry , Career Choice , Students, Medical
16.
Circulation ; 102(16): 1924-30, 2000 Oct 17.
Article in English | MEDLINE | ID: mdl-11034940

ABSTRACT

BACKGROUND: Fibrinogen binding to the active conformation of the alpha(IIb)beta(3) integrin receptor (glycoprotein IIb/IIIa) and cytoskeletal reorganization are important events in platelet function. Tyrosine phosphorylation of platelet proteins plays an essential role in platelet signal transduction pathways. We studied the participation of tyrosine kinases on these aspects of platelet reactivity and their importance in cyclooxygenase (COX)-1-independent mechanisms in thrombin-stimulated human platelets. METHODS AND RESULTS: Using washed platelets from normal donors and tyrphostin-A47 and aspirin as tyrosine kinase and COX-1 inhibitors, respectively, we found that tyrphostin-A47 downregulated (1) the thrombin-activated conformational change of alpha(IIb)beta(3), (2) actin polymerization and cytoskeletal reorganization, and (3) the quantity of tyrosine-phospho-rylated proteins associated with the reorganized cytoskeleton. The latter are important components of multimolecular signaling complexes. Concomitantly, platelet aggregation and secretion were significantly reduced. Aspirin did not affect receptor activation or tyrosine phosphorylation but did decrease the initial (30-second) burst of actin polymerization. Importantly, aspirin significantly amplified the inhibitory effect of tyrphostin-A47 on all aspects of platelet reactivity that we evaluated. CONCLUSIONS: Tyrosine protein phosphorylation is a regulatory control system of the inside-out mechanism of alpha(IIb)beta(3) activation and cytoskeletal assembly in thrombin-stimulated human platelets. Inhibition of these aspects of platelet function with tyrphostin-A47 is amplified when platelets are treated with aspirin. Therefore, tyrosine phosphorylation is a major component of early signaling events and of COX-1-independent mechanisms of thrombin-induced platelet reactivity. The study results may indicate a novel target for therapeutic intervention.


Subject(s)
Blood Platelets/metabolism , Cytoskeletal Proteins/metabolism , Platelet Glycoprotein GPIIb-IIIa Complex/metabolism , Thrombin/metabolism , Aspirin/pharmacology , Blood Platelets/cytology , Blood Platelets/drug effects , Cyclooxygenase 1 , Down-Regulation , Enzyme Inhibitors/pharmacology , Humans , Isoenzymes/antagonists & inhibitors , Membrane Proteins , Phosphorylation/drug effects , Platelet Aggregation/drug effects , Prostaglandin-Endoperoxide Synthases , Protein-Tyrosine Kinases/antagonists & inhibitors , Signal Transduction/drug effects , Thrombin/pharmacology , Tyrosine/metabolism , Tyrphostins/pharmacology
17.
Av. odontoestomatol ; 16(3): 171-176, abr. 2000. ilus, tab, graf
Article in Es | IBECS | ID: ibc-9654

ABSTRACT

Se presenta un estudio experimental in vitro en el que se compara la retención que ofrecen los retenedores circunferenciales tipo Ackers de resina acetálica con los de cromo-cobalto. Se realizan para ello 6 coronas de cromo-níquel, 3 con forma de canino superior y 3 con forma de primer premolar superior y cada una de ellas con un grado diferente de retención (0.25, 0.50 y 0.75 mm). Sobre cada una de ellas se confecciona un retenedor de resina acetálica y uno de cromo-cobalto, siendo testados por una máquina Instron. Los resultados confirman que los retenedores de cromo-cobalto son más retentivos, y que los acetálicos ofrecen una retención suficiente para cumplir su cometido (AU)


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Subject(s)
Humans , Dental Prosthesis Retention/methods , Orthodontic Retainers , Metals, Heavy/therapeutic use , Resins/therapeutic use , Denture, Partial, Removable , Tooth Crown , Cuspid , Bicuspid , Chromium/therapeutic use , Nickel/therapeutic use , Cobalt/therapeutic use
18.
Rev Eur Odontoestomatol ; 2(5): 325-8, 1990.
Article in Spanish | MEDLINE | ID: mdl-2094265

ABSTRACT

We have a bibliografical study of the composite odontomas from the diagnostical point of view. We will present two clinical cases. Once the medical revision is done, and the tumor is localized, we analyze lesions associated with the tumor and compare the diagnostic from the clinical point of view as well as the radiografical point of view.


Subject(s)
Maxillary Neoplasms/diagnosis , Odontogenic Tumors/diagnosis , Odontoma/diagnosis , Child , Humans , Male , Tooth Eruption , Tooth Fractures
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