Subject(s)
Desensitization, Immunologic , Passive Cutaneous Anaphylaxis , Peanut Hypersensitivity/prevention & control , Adult , Aged , Allergens/adverse effects , Allergens/immunology , Arachis/adverse effects , Case-Control Studies , Desensitization, Immunologic/methods , Dose-Response Relationship, Immunologic , Female , Humans , Male , Middle Aged , Peanut Hypersensitivity/diagnosis , Peanut Hypersensitivity/immunology , Treatment Outcome , Young AdultABSTRACT
BACKGROUND: Octylisothiazolinone is a biocide that has been reported as a moderate, but rare contact allergen. OBJECTIVES: To investigate the occurrence of octylisothiazolinone contact allergy and allergic contact dermatitis diagnosed and registered in the Allergen Bank at Odense University Hospital during the past 20 years. Octylisothiazolinone has been used for targeted testing only. METHOD: All octylisothiazolinone-patch test results registered in the Allergen Bank between January 1992 and February 2012 were analyzed. RESULTS: A total of 20 out of 648 patients patch tested with octylisothiazolinone had positive reactions. The majority of the patients (90%) with relevant sensitizations to octylisothiazolinone had been exposed in occupational settings and most patients were painters. CONCLUSIONS: Octylisothiazolinone is a relevant sensitizer.
Subject(s)
Dermatitis, Allergic Contact/diagnosis , Dermatitis, Occupational/diagnosis , Occupational Exposure/adverse effects , Paint/adverse effects , Thiazoles/adverse effects , Adult , Causality , Denmark/epidemiology , Dermatitis, Allergic Contact/epidemiology , Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/epidemiology , Dermatitis, Occupational/etiology , Female , Humans , Male , Middle Aged , Occupational Exposure/statistics & numerical data , Patch Tests/statistics & numerical data , Risk Factors , Thiazoles/administration & dosage , Workplace , Young AdultABSTRACT
BACKGROUND: Painters are among the occupational groups that most commonly experience occupational contact dermatitis, but few investigations exist concerning this occupation. OBJECTIVES: To characterize painters with contact dermatitis and identify the most common allergens associated with the occupation. Materials and methods. All patch test results of 219 painters and 1095 matched controls registered by the Danish Contact Dermatitis Group between 2001 and 2010 were analysed. RESULTS: Hand eczema (p < 0.0001) and occupational contact dermatitis (p < 0.0001) were observed significantly more often in the painters than in the group of controls. Sensitizations to the following allergens from the European baseline series were associated with the occupation and were statistically significant: methylchloroisothiazolinone/methylisothiazolinone, epoxy resin, formaldehyde, and quaternium-15. Three different isothiazolinones emerged as the most frequent sensitizers of the allergens tested in addition to the baseline series. CONCLUSIONS: The results indicate that painters have an increased risk of developing occupational hand eczema. Isothiazolinones and epoxy resin proved to be the two most frequent sensitizers in painters.
