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1.
Hippocampus ; 20(10): 1109-23, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20872737

ABSTRACT

Increased excitability and plasticity of adult-generated hippocampal granule cells during a critical period suggests that they may "orthogonalize" memories according to time. One version of this "temporal tag" hypothesis suggests that young granule cells are particularly responsive during a specific time period after their genesis, allowing them to play a significant role in sculpting CA3 representations, after which they become much less responsive to any input. An alternative possibility is that the granule cells active during their window of increased plasticity, and excitability become selectively tuned to events that occurred during that time and participate in later reinstatement of those experiences, to the exclusion of other cells. To discriminate between these possibilities, rats were exposed to different environments at different times over many weeks, and cell activation was subsequently assessed during a single session in which all environments were revisited. Dispersing the initial experiences in time did not lead to the increase in total recruitment at reinstatement time predicted by the selective tuning hypothesis. The data indicate that, during a given time frame, only a very small number of granule cells participate in many experiences, with most not participating significantly in any. Based on these and previous data, the small excitable population of granule cells probably correspond to the most recently generated cells. It appears that, rather than contributing to the recollection of long past events, most granule cells, possibly 90-95%, are effectively "retired." If granule cells indeed sculpt CA3 representations (which remains to be shown), then a possible consequence of having a new set of granule cells participate when old memories are reinstated is that new representations of these experiences might be generated in CA3. Whatever the case, the present data may be interpreted to undermine the standard "orthogonalizer" theory of the role of the dentate gyrus in memory.


Subject(s)
CA3 Region, Hippocampal/cytology , CA3 Region, Hippocampal/physiology , Neurogenesis/physiology , Neurons/cytology , Neurons/physiology , Animals , Electroshock , Environment, Controlled , Male , Memory/physiology , Models, Neurological , Neuronal Plasticity/physiology , Rats , Rats, Inbred F344 , Time Factors
2.
Neuroscience ; 130(2): 519-26, 2005.
Article in English | MEDLINE | ID: mdl-15664708

ABSTRACT

One of several tenable hypotheses that can be proposed to explain the complex dynamics of spatially selective hippocampal neural activity postulates that the region of space over which a given cell receives its external input is actually much smaller than the classical 'place field.' According to this notion, the later portions of the field reflect some form of network hysteresis resulting from 'reverberatory' activity within reentrant, synaptically coupled cell assemblies within the hippocampus. This hypothesis predicts that transient, global inhibition, induced after the onset of firing, might truncate the remainder of the place field. To test this hypothesis, principal afferents to the hippocampus were stimulated bilaterally in rats running on a circular track, evoking widespread inhibition throughout the hippocampus, and abolishing all spike activity from simultaneously recorded populations of CA1 pyramidal cells for periods of 150-300 ms. Stimulation at any point within the place field of a given cell suppressed firing only for such brief intervals, followed by an immediate resumption for the remainder of the field. These results suggest that without additional cellular and/or synaptic mechanisms, reverberatory activity alone within the hippocampus does not account for the shape and spatial extent of place fields.


Subject(s)
Action Potentials/physiology , Hippocampus/physiology , Nerve Net/physiology , Orientation/physiology , Space Perception/physiology , Synaptic Transmission/physiology , Afferent Pathways/physiology , Animals , Electric Stimulation , Male , Models, Neurological , Neural Inhibition/physiology , Pyramidal Cells/physiology , Rats , Rats, Inbred F344 , Synapses/physiology
3.
J Neurosci ; 21(12): 4505-13, 2001 Jun 15.
Article in English | MEDLINE | ID: mdl-11404438

ABSTRACT

Converging evidence suggests that the hippocampus is essential for goal-directed spatial navigation. Successful navigation requires not only the ability to compute an appropriate path toward the target but is also guided by recognition of places along the trajectory between start and goal. To determine whether the hippocampus contributes to place recognition, we trained rats with hippocampal lesions in an annular water maze with a remotely controlled escape platform at a constant location in the corridor. The platform remained submerged and unavailable until the rat had swum at least one full lap. Probe trials with the platform unavailable for 60 sec were inserted at regular intervals. In these trials, the rat would swim over the platform several times, regardless of its navigational abilities. After a few training sessions, all sham-operated control animals reduced their swim velocity when they approached the platform, indicating that they recognized the target location. Rats with hippocampal lesions, in contrast, swam at the same velocity as elsewhere in the corridor. Preoperative training or prolonged postoperative training did not alleviate the deficit. Rats with hippocampal lesions were able to learn a cued version of the task, which implies that the failure to slow down was not attributable to motor inflexibility. Thus, hippocampal lesions caused a severe but selective deficit in the identification of a location, suggesting that the hippocampus may be essential for image recognition during spatial navigation.


Subject(s)
Goals , Hippocampus/physiology , Maze Learning/physiology , Recognition, Psychology/physiology , Spatial Behavior/physiology , Analysis of Variance , Animals , Appetitive Behavior/drug effects , Appetitive Behavior/physiology , Cues , Hippocampus/cytology , Hippocampus/drug effects , Ibotenic Acid/administration & dosage , Male , Microinjections , Rats , Rats, Long-Evans , Reaction Time/drug effects , Recognition, Psychology/drug effects , Spatial Behavior/drug effects , Swimming/physiology
4.
Eur J Neurosci ; 13(6): 1197-208, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11285017

ABSTRACT

To provide a background for studying place-related activity in hippocampal neurons during spatial learning, we compared the activity of hippocampal place cells in an annular watermaze and an analogous land-based task. Complex-spike cells had robust place correlates in both conditions, and a significant proportion of the cells had place fields at the same locations. However, the in-field firing rates were slightly higher in the wet condition. Elevated firing was observed also in an open water task. There was no enhancement when the platform location was varied randomly or when there was no platform at all. Second, the place fields were under stronger directional modulation during swimming. In the annular task, directional sensitivity appeared regardless of whether the animals were trained to find a platform or not. There were directionally modulated units also in the open watermaze, but the number was smaller than in the corridor. Altogether, these observations suggest that place fields in the watermaze are largely controlled by the same factors as on dry land, in spite of the differences in kinaesthetic and vestibular input. Differences in firing rate and directional control may depend on the geometric and cognitive structure of the task rather than the medium on which the rats are moving.


Subject(s)
Hippocampus/physiology , Maze Learning/physiology , Pyramidal Cells/physiology , Space Perception/physiology , Animals , Behavior, Animal/physiology , Brain Mapping , Electrophysiology , Hippocampus/cytology , Male , Rats , Rats, Long-Evans , Swimming/physiology
5.
J Neurosci ; 21(5): 1635-44, 2001 Mar 01.
Article in English | MEDLINE | ID: mdl-11222654

ABSTRACT

To explore the plastic representation of information in spatially selective hippocampal pyramidal neurons, we made multiple single-unit recordings in rats trained to find a hidden platform at a constant location in a hippocampal-dependent annular watermaze task. Hippocampal pyramidal cells exhibited place-related firing in the watermaze. Place fields tended to accumulate near the platform, even in probe trials without immediate escape. The percentage of cells with peak activity around the hidden platform was more than twice the percentage firing in equally large areas elsewhere in the arena. The effect was independent of the actual position of the platform in the room frame. It was dissociable from ongoing motor behavior and was not related to linear or angular speed, swim direction, or variation in hippocampal theta activity. There was no accumulation of firing in any particular region in rats that were trained with a variable platform location. These training-dependent effects suggest that regions of particular behavioral significance may be over-represented in the hippocampal spatial map, even when these regions are completely unmarked.


Subject(s)
Hippocampus/physiology , Maze Learning/physiology , Pyramidal Cells/physiology , Action Potentials/physiology , Animals , Appetitive Behavior/physiology , Behavior, Animal/physiology , Electrodes, Implanted , Electroencephalography , Male , Motor Activity/physiology , Neuronal Plasticity/physiology , Rats , Rats, Long-Evans , Signal Processing, Computer-Assisted , Spatial Behavior/physiology
6.
J Neurosci ; 21(1): 356-62, 2001 Jan 01.
Article in English | MEDLINE | ID: mdl-11150353

ABSTRACT

If information is stored as distributed patterns of synaptic weights in the hippocampal formation, retention should be vulnerable to electrically induced long-term potentiation (LTP) of hippocampal synapses after learning. This prediction was tested by training animals in a spatial water maze task and then delivering bursts of high-frequency (HF) or control stimulation to the perforant path in the angular bundle. High-frequency stimulation induced LTP in the dentate gyrus and probably also at other hippocampal termination sites. Retention in a later probe test was disrupted. When the competitive NMDA receptor antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) was administered before the high-frequency stimulation, water maze retention was unimpaired. CPP administration blocked the induction of LTP. Thus, high-frequency stimulation of hippocampal afferents disrupts memory retention only when it induces a change in the spatial pattern of synaptic weights. The NMDA receptor dependency of this retrograde amnesia is consistent with the synaptic plasticity and memory hypothesis.


Subject(s)
Amnesia, Retrograde/metabolism , Long-Term Potentiation , Memory Disorders/metabolism , Receptors, N-Methyl-D-Aspartate/metabolism , Afferent Pathways/physiology , Animals , Dentate Gyrus/cytology , Dentate Gyrus/physiology , Electric Stimulation , Electrodes, Implanted , Evoked Potentials/physiology , Excitatory Amino Acid Antagonists/pharmacology , Excitatory Postsynaptic Potentials/physiology , Hippocampus/physiology , Hippocampus/surgery , Long-Term Potentiation/drug effects , Long-Term Potentiation/physiology , Male , Maze Learning/drug effects , Maze Learning/physiology , Neuronal Plasticity/physiology , Perforant Pathway/physiology , Piperazines/pharmacology , Rats , Rats, Long-Evans , Reaction Time/drug effects , Reaction Time/physiology , Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors , Retention, Psychology/drug effects , Retention, Psychology/physiology
8.
J Neurosci ; 19(24): RC49, 1999 Dec 15.
Article in English | MEDLINE | ID: mdl-10594093

ABSTRACT

Spatial learning is impaired by NMDA receptor antagonists at doses that block hippocampal long-term potentiation (LTP). The deficit is not observed in animals that have received spatial or nonspatial pretraining in a different water maze. To determine whether this conditional impairment reflects debilitating sensorimotor effects of NMDA receptor antagonists in na¿ve animals, we compared spatial learning in na¿ve and pretrained animals in which induction of LTP was blocked by a saturation procedure with no obvious effects on sensorimotor functions. Rats with unilateral hippocampal lesions were implanted with multiple bipolar stimulation electrodes in the angular bundle and a recording electrode in the dentate gyrus of the intact hemisphere. Half of the rats were pretrained to find a hidden platform in a water maze. A week later, pretrained and na¿ve rats received either high-frequency (HF) or low-frequency (LF) stimulation at 2 hr intervals, until no further LTP could be induced. The stimulation did not interefere with performance on a balance task or a visual platform task. After stimulation, all rats were trained in a second water maze. Whereas na¿ve HF animals were impaired, pretrained HF animals acquired the new task rapidly and searched as extensively around the platform as LF control animals. These results suggest that pretraining prevents disruption of spatial learning after saturation of LTP in the absence of sensorimotor impairment, that hippocampal LTP might not be crucial for spatial representation per se, and that LTP may be involved only when spatial and contextual or procedural learning take place simultaneously.


Subject(s)
Dentate Gyrus/physiology , Hippocampus/physiology , Long-Term Potentiation/physiology , Maze Learning/physiology , Animals , Electric Stimulation , Evoked Potentials/physiology , Male , Neuronal Plasticity/physiology , Rats , Rats, Long-Evans , Reaction Time/physiology
9.
Neurosci Biobehav Rev ; 23(5): 661-72, 1999 May.
Article in English | MEDLINE | ID: mdl-10392658

ABSTRACT

Long-term potentiation (LTP) has become a leading candidate mechanism for memory formation. The proposed link between LTP and memory rests primarily on a single type of behavioural evidence: disruption of learning by interventions that block critical steps in the induction of LTP. As such blockade may disrupt non-mnemonic functions also, the LTP-learning question should be approached with multiple strategies. One alternative approach is to determine whether hippocampus-dependent learning is blocked by saturation of hippocampal LTP before training. Early investigations found that spatial learning was impaired after cumulative LTP in dentate perforant-path synapses. Several groups failed to replicate these findings, but it is now clear that hippocampus-dependent spatial learning is disrupted only if LTP is saturated throughout the terminal field of the tetanized pathway. Moreover, to prevent compensatory modifications in the hippocampal network, a massed tetanization and training protocol may be required. The blockade of learning by repetition of the very same stimulus that induces LTP suggests that LTP-like modifications are necessary for memory encoding in the hippocampus.


Subject(s)
Hippocampus/physiology , Learning/physiology , Long-Term Potentiation/physiology , Synapses/physiology , Animals , Humans
10.
Cell Mol Life Sci ; 55(4): 593-600, 1999 Apr.
Article in English | MEDLINE | ID: mdl-10357229

ABSTRACT

Although information may be stored in the brain is changes in the strength of existing synapses, formation of new synapses has long been thought of as an additional substrate for memory storage. The identification of subcellular structural changes following learning in mammals poses a serious 'needle-in-the-haystack' problem. In most attempts to demonstrate structural plasticity during learning, animals have been exposed for prolonged periods to complex environments, where they are confronted with a variety of sensory, motor- and spatial challenges throughout the exposure period. These environments are thought to promote several forms of learning. Repeated exposure to such environments has been shown to increase the density of spines and dendritic complexity in relevant brain structures. The number of neurons has also been reported to increase in some areas. It is not clear, however, whether the new synapses emerging from these forms of plasticity mediate specific information storage, or whether they reflect a more general sophistication of the excited parts of the network.


Subject(s)
Memory/physiology , Synapses/physiology , Animals , Hippocampus/cytology , Learning/physiology , Mammals , Neuronal Plasticity
11.
Science ; 281(5385): 2038-42, 1998 Sep 25.
Article in English | MEDLINE | ID: mdl-9748165

ABSTRACT

If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naïve test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (<10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.


Subject(s)
Hippocampus/physiology , Long-Term Potentiation/physiology , Maze Learning/physiology , Animals , Dentate Gyrus/physiology , Electric Stimulation , Electrodes, Implanted , Evoked Potentials , Excitatory Postsynaptic Potentials , Male , Perforant Pathway , Rats , Synapses/physiology , Tetany
12.
J Neurosci ; 18(18): 7535-42, 1998 Sep 15.
Article in English | MEDLINE | ID: mdl-9736671

ABSTRACT

To determine whether memory is processed in a localized or distributed manner by the hippocampus, we inactivated small regions of the structure in pretrained rats before a retention test. Ibotenic acid-induced lesions removing 40% of the hippocampal tissue disrupted retrieval of spatial memory in a water maze but failed to affect new learning or retrieval of a task that was acquired postoperatively. Partial inactivation of the hippocampus by local intrahippocampal 5-aminomethyl-3-hydroxyisoxazole muscimol infusion also impaired retrieval but not new learning. This impairment was temporary; infusions had no effect on retrieval of predrug performance when the test was conducted 48 hr after the infusion. Systematic variation of the volume of dorsal and ventral hippocampal lesions showed that successful retrieval required the integrity of the entire dorsal 70% of the hippocampus. Our data suggest that although spatial tasks can be acquired with local ensembles of hippocampal neurons when other parts of the hippocampus are inactivated, spatial memory is normally both encoded and retrieved by a widely distributed hippocampal network.


Subject(s)
Hippocampus/physiology , Maze Learning/physiology , Memory/physiology , Spatial Behavior/physiology , Animals , Conditioning, Psychological/drug effects , Conditioning, Psychological/physiology , GABA Agonists/pharmacology , Hippocampus/surgery , Male , Maze Learning/drug effects , Muscimol/pharmacology , Rats , Rats, Inbred Strains , Septal Nuclei/physiology , Spatial Behavior/drug effects
13.
Hippocampus ; 8(6): 608-19, 1998.
Article in English | MEDLINE | ID: mdl-9882018

ABSTRACT

The hippocampus is critically involved in certain kinds of memory. During memory formation, it may operate as an integrated unit, or isolated parts may be responsible for different functions. Recent evidence suggests that the hippocampus is functionally differentiated along its dorsoventral (septotemporal) axis. The cortical and subcortical connections of the dorsal and ventral hippocampus are different, with information derived from the sensory cortices entering mainly in the dorsal two-thirds or three-quarters of the dentate gyrus. Rats can acquire a spatial navigation task if small tissue blocks are spared within this region, but equally large blocks at the ventral end are not capable of supporting spatial learning. In primates, the posterior hippocampus (corresponding to the dorsal hippocampus of rodents) appears to be more important than anterior areas for encoding of spatial memory and certain forms of nonspatial memory. The ventral (or anterior) hippocampal formation is to some extent disconnected from the rest of the structure both in terms of intrahippocampal and extrahippocampal connections and may be performing functions that are qualitatively different from, and independent of, those of the dorsal hippocampal formation.


Subject(s)
Hippocampus/anatomy & histology , Hippocampus/physiology , Memory/physiology , Animals , Humans , Rats , Space Perception
14.
J Comp Neurol ; 380(3): 373-81, 1997 Apr 14.
Article in English | MEDLINE | ID: mdl-9087519

ABSTRACT

The hippocampus is critically involved in spatial learning. Spatial training in adult rats, which improved their spatial learning ability, increased the number of excitatory hippocampal CA1 spine synapses on basal dendrites as compared with either isolated or standardly housed animals (Moser et al. [1994] Proc. Natl. Acad. Sci. USA 91:12673-12675). In this article, we report that spine synapses on oblique apical dendritic branches do not increase in density or number after the same type of training. When examining the variability of the spine density on basal CA1 dendrites by using variance component analysis, the variance associated with the cells was twice as large in all three groups as that coupled to the rats. Analysis of the spine density plots shows that the enhanced spine density after spatial training is found in most cells recorded from the trained group but that a small subset of CA1 neurones are particularly well supplied with spines. The trained group had a significant right-skewed tail of the spine distribution, i.e., training caused high spine density to occur in a small subset of dendritic segments. Conversely, the isolated group had a significant left-skewed spine distribution, indicating that some of the dendritic segments were undersupplied with spines, whereas the paired group displayed no asymmetry.


Subject(s)
Cell Count , Dendrites/ultrastructure , Pyramidal Cells/ultrastructure , Spatial Behavior/physiology , Spine/ultrastructure , Animals , Male , Microscopy, Confocal , Rats , Social Isolation
15.
J Physiol Paris ; 90(5-6): 349, 1996.
Article in English | MEDLINE | ID: mdl-9089511

ABSTRACT

Learning through exploration gives increased synaptic field potentials in the perforant path/dentate synapses, largely due to an activity-dependent brain temperature increase. After temperature compensation, spatial learning was associated with small, but significant, STP-like changes of the field potential lasting 20-30 min. A group of spatially trained adult rats showed faster spatial learning and about 10% higher basal dendritic spine density (LY-filled) compared to two control groups. With unchanged dendritic length and branching pattern, the results suggest the formation of new synapses.


Subject(s)
Exploratory Behavior , Hippocampus/physiology , Learning/physiology , Neurons/physiology , Synapses/physiology , Synaptic Transmission , Animals , Dendrites/physiology , Dentate Gyrus/physiology , Long-Term Potentiation , Neuronal Plasticity , Pyramidal Cells/physiology , Rats , Space Perception
16.
Proc Natl Acad Sci U S A ; 92(21): 9697-701, 1995 Oct 10.
Article in English | MEDLINE | ID: mdl-7568200

ABSTRACT

We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support spatial learning in a water maze, provided it was at the septal (dorsal) pole of the hippocampus. Lesions of the septal pole, leaving 60% of the hippocampi intact, caused a learning deficit, although normal electrophysiological responses, synaptic plasticity, and preserved acetylcholinesterase staining argue for adequate function of the remaining tissue. Thus, with an otherwise normal brain, hippocampal-dependent spatial learning only requires a minislab of dorsal hippocampal tissue.


Subject(s)
Hippocampus/physiology , Maze Learning/physiology , Spatial Behavior/physiology , Acetylcholinesterase/isolation & purification , Animals , Electric Stimulation , Electrophysiology , Excitatory Amino Acid Agonists/pharmacology , Hippocampus/drug effects , Hippocampus/pathology , Histocytochemistry , Ibotenic Acid/pharmacology , Learning , Maze Learning/drug effects , Rats , Rats, Inbred Strains , Spatial Behavior/drug effects , Swimming
17.
Proc Natl Acad Sci U S A ; 91(26): 12673-5, 1994 Dec 20.
Article in English | MEDLINE | ID: mdl-7809099

ABSTRACT

The search for cellular correlates of learning is a major challenge in neurobiology. The hippocampal formation is important for learning spatial relations. A possible long-lasting consequence of such spatial learning is alteration of the size, shape, or number of excitatory synapses. The dendritic spine density is a good index for the number of hippocampal excitatory synapses. By using laser-scanning confocal microscopy, we observed a significantly increased spine density in CA1 basal dendrites of spatially trained rats when compared to nontrained controls. With unchanged dendritic length, the higher spine density reflects an increased number of excitatory synapses per neuron associated with spatial learning.


Subject(s)
Dendrites/ultrastructure , Hippocampus/physiology , Maze Learning/physiology , Animals , Hippocampus/cytology , Male , Neuronal Plasticity , Rats
18.
Learn Mem ; 1(1): 55-73, 1994.
Article in English | MEDLINE | ID: mdl-10467586

ABSTRACT

Certain kinds of learning may be related to potentiation of transmission at specific hippocampal synapses. We investigated whether transmission across the perforant-path/granule-cell synapses of the dentate gyrus is facilitated when rats are learning about novel objects in an open field during exploration. Such studies are complicated by the sensitivity of hippocampal field potentials to brain temperature change. To control for this, we have recorded both brain temperature and field potentials and compared potentials sampled during exploration with potentials taken at corresponding brain temperature in a passive warming situation, with the animals at rest. Relative to these reference potentials, both the f-EPSP slope and the population spike were elevated while the rats explored. The potentiation reached its maximum within < 5 sec after the exploration began. During the first 2 min, the f-EPSP slope was enhanced by 6.5% relative to the control values. The potentiation then decayed, reaching the reference values after 20-30 min of exploration. Significant potentiation required exploration above a certain minimum intensity. Control experiments showed that the changes were neither mimicked by arousal in response to aversive stimuli nor by motor activity. It is suggested that the facilitated transmission across the perforant-path/dentate synapses may be involved in learning during exploration.


Subject(s)
Arousal/physiology , Body Temperature/physiology , Brain/physiology , Dentate Gyrus/physiology , Exploratory Behavior/physiology , Learning/physiology , Motor Activity/physiology , Synapses/physiology , Animals , Male , Rats , Rats, Long-Evans
19.
Neuroreport ; 5(3): 317-20, 1993 Dec 13.
Article in English | MEDLINE | ID: mdl-8298097

ABSTRACT

To investigate whether hippocampal synaptic transmission is enhanced during learning, we recorded synaptic field potentials in the dentate gyrus in response to stimulation of the perforant path in rats exploring a novel environment. Because these signals rapidly grow during brain temperature elevation, caused by any motor activity, the potentials were compared with signals sampled at similar brain temperatures after passive warming. Both the field excitatory postsynaptic potential (f-EPSP) and the population spike increased significantly early in the exploration, relative to temperature-matched control potentials. The effect decayed within 15-30 minutes. This is the first demonstration of a temperature-independent synaptic potentiation in the hippocampus during learning about the environment. The time course is similar to that of short-term potentiation.


Subject(s)
Exploratory Behavior/physiology , Hippocampus/physiology , Learning/physiology , Neuronal Plasticity/physiology , Synapses/physiology , Animals , Body Temperature/physiology , Evoked Potentials/physiology , Male , Rats , Space Perception/physiology
20.
J Neurosci ; 13(9): 3916-25, 1993 Sep.
Article in English | MEDLINE | ID: mdl-8366351

ABSTRACT

The hippocampus plays an essential role in spatial learning. To investigate whether the whole structure is equally important, we compared the effects of variously sized and localized hippocampal aspiration lesions on spatial learning in a Morris water maze. The volume of all hippocampal lesions was determined. Dorsal hippocampal lesions consistently impaired spatial learning more than equally large ventral lesions. The dorsal lesions had to be larger than 20% of the total hippocampal volume to prolong final escape latencies. The acquisition rate and precision on a probe test without platform were sensitive to even smaller dorsal lesions. The degree of impairment correlated with the lesion volume. In contrast, the lesions of the ventral half of the hippocampus spared both the rate and the precision of learning unless nearly all of the ventral half was removed. There was no significant effect of the location (dorsal or ventral) of damage to the overlying neocortex only. In conclusion, the dorsal half of the hippocampus appears more important for spatial learning than the ventral half. The spatial learning ability seems related to the amount of damaged dorsal hippocampal tissue, with a threshold at about 20% of the total hippocampal volume, under which normal learning can occur.


Subject(s)
Brain Mapping , Hippocampus/physiology , Learning/physiology , Space Perception/physiology , Animals , Cerebral Cortex/physiology , Female , Pyramidal Tracts/physiology , Rats , Time Factors
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