1.
J Org Chem
; 79(7): 3111-8, 2014 Apr 04.
Article
in English
| MEDLINE
| ID: mdl-24606120
ABSTRACT
An efficient and highly stereoselective strategy for the synthesis of 2,3-substituted thiochromenes having a complex and easily transformable group at the stereogenic center has been developed via a tandem thio-Michael addition reaction of an in situ generated α,ß-unsaturated aldehyde sugar derivative. The protocol is superior to reported protocols in that the carbohydrate-derived substituent at the stereogenic center of the thiochromene is versatile and is amenable for further transformation.