1.
Ann Plast Surg
; 17(4): 288-91, 1986 Oct.
Article
in English
| MEDLINE
| ID: mdl-3273108
ABSTRACT
Polydimethylsiloxane (silicone) implants were subcutaneously placed in the back of diabetic and normal rats. After three months the rats were killed and the fibrous capsule around the implants was histologically and biochemically examined. A significant quantitative difference (p less than 0.001) was found in the thickness of the capsules, which were two to three times thicker in the diabetic animals. The biochemistry showed an increase of neutral salt-soluble collagen in the diabetic group; electrophoresis revealed only type I collagen in the diabetic and type I and III in the normal rats. From this experimental trial it seems that diabetes mellitus is another factor in formation of a thick capsule around silicone implants.
Subject(s)
Breast , Diabetes Mellitus, Experimental/pathology , Prostheses and Implants/adverse effects , Silicone Elastomers/adverse effects , Animals , Blood Glucose/analysis , Diabetes Mellitus, Experimental/metabolism , Dimethylpolysiloxanes/adverse effects , Disease Models, Animal , Glucose Tolerance Test , Prosthesis Failure , Rats , Skin/drug effects , Skin/metabolism , Skin/pathology
2.
Br Vet J
; 133(3): 231-8, 1977.
Article
in English
| MEDLINE
| ID: mdl-608063
