ABSTRACT
BACKGROUND: Chronic myeloid leukemia (CML), is the first malignancy that related to the chromosomal abnormality and include 15-20% of all adulthood leukemia. AIMS: This study aimed to compare the hematologic, breakpoint cluster region-abelson (BCR-ABL) and liver function enzymes changes during treatment period of Imatinib. SETTINGS AND DESIGN: A noncurrent clinical trial study. MATERIALS AND METHODS: New incident CML patients received Iranian made or Indian-made Imatinib after baseline measurement. Hematologic, BCR-ABL, electrolytes and liver function enzymes measured again after 24 weeks. STATISTICAL ANALYSIS USED: Paired t-test and independent t-test was used to assess the effect of treatment in within and between groups, respectively. RESULTS: Imatinib has a decreasing impact on white blood cells and placates. While an increasing effect on hemoglobin concentration. Iranian made and Indian-made Imatinib has a same effect on improvement of hematologic, BCR-ABL, electrolytes in CML patients. However, the liver changes of Imatinib were not clinically significant. CONCLUSION: The Iranian-made Imatinib can be used as a replacement for Indian made ones without any statistical and clinical significant difference on Improvement of CML patients.
Subject(s)
Imatinib Mesylate/administration & dosage , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/blood , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Aged , Blood Cell Count , Chromosome Aberrations , Drug Resistance, Neoplasm/genetics , Electrolytes/blood , Female , Fusion Proteins, bcr-abl/blood , Fusion Proteins, bcr-abl/genetics , Humans , Imatinib Mesylate/adverse effects , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology , Liver/drug effects , Liver/enzymology , Liver/pathology , Male , Middle AgedABSTRACT
Breast cancer is the most common and most preventable cancer in women and early detection has the important role in reducing its morbidity and mortality, so increase 95% survival time. The present study conducted to compare the effects of two educational methods on knowledge, attitude and practices of Arak physicians. An interventional study after randomized allocation of each 64 physician to any of two different educational methods (video and systematic review) used to compare knowledge; attitude and practices score variation about breast cancer screening skills. Data collection carried out with structured questionnaire and entered to SPSS software. Data analyzed by t-test, paired t-test and Man-Whitney test in significant level of 0.05. Mean of total score of knowledge, attitude and practices (KAP) showed a significant difference before and after training and the total score of KAP increase (p < 0.05). But KAP score variation and their subscales were same in two groups and didn't show any significant difference (p > 0.05). Although KAP in Arak physician is appropriate and any educational program increase their KAP level, but continuing and repetition of educational courses seems to be necessary.
