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Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
Tecle, Haile; Shao, Jianxing; Li, Yanhong; Kothe, Michael; Kazmirski, Steven; Penzotti, Julie; Ding, Yuan-Hua; Ohren, Jeffrey; Moshinsky, Deb; Coli, Rocco; Jhawar, Nidhi; Bora, Emilia; Jacques-O'Hagan, Suzanne; Wu, Joe.
Bioorg Med Chem Lett ; 19(1): 226-9, 2009 Jan 01.
Article in English | MEDLINE | ID: mdl-19019675

ABSTRACT

An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket or pockets closely related to it may exist in kinases other than MEK.


Subject(s)
Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors , Protein Kinase Inhibitors/chemical synthesis , Catalytic Domain , Drug Design , Protein Kinase Inhibitors/chemistry , Protein Kinase Inhibitors/pharmacology
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