ABSTRACT
The results of the clinical studies indicate that DNAase treatment of the patients with maxillofacial abscesses and phlegmons increases the effect of antibacterial therapy. During microbiologic testing in the patients treated with DNAase together with antibacterial therapy it was recorded a marked decrease in the plating of bacteria. This effect is supposed to be connected with enzyme ability to penetrate into microbial biofilms and disturb microbial interactions.
Subject(s)
Abscess/drug therapy , Cellulitis/drug therapy , Deoxyribonucleases/therapeutic use , Maxillary Diseases/drug therapy , Adolescent , Adult , Aged , Anti-Bacterial Agents/therapeutic use , Drug Synergism , Drug Therapy, Combination , Follow-Up Studies , Humans , Middle Aged , Retrospective Studies , Treatment OutcomeABSTRACT
An epidemic outbreak of acute respiratory infection (295 patients) in an organized group of young people was observed in December-May 1997-1998. Pneumococcal etiology was established by means of indirect immunofluorescence reaction in cases of outpatient pneumonia (81.9%), acute bronchitis (80%) and acute respiratory diseases (92.5%). Respiratory chlamydiosis caused by Chlamydia pneumoniae was detected in enzyme immunoassay with the use of immunoComb Chlamydia Bivalent IgG in patients with pneumonia (66.7%), acute bronchitis (60%) and acute respiratory diseases (50%). Synergic relationship between pneumococcal and chlamydial infections was noted.
