Approaches to prediction of the adaptive state of the brain energetic system under conditions of hypoxia.

We showed that mitochondrial creatine kinase activity can be predicted from the ATP level and that changes in ATP content can be evaluated by activity of mitochondrial creatine kinase under experimental conditions.

[Dependence between mitochondrial creatine kinase activity and ATP level in the brain ischemia].

The disturbances of blood circulation changes metabolism and energy reactions in the brain. The method of mathematical analysis is used for the study of the dependence between the activity mitochondrial creatine kinase (CK) and ATP level the brains of rats subjected to acute and chronic ischemia. A model describing this dependence under different conditions of the activity of organisms has been proposed. Thus it is possible to predict catalytic properties of CK based on ATP level.

[The use of empirical correlations in adenine nucleotide systems for prediction of AMP level in the brain in hypoxia]. / Ispol'zovanie émpiricheskikh zavisimostei v sisteme adeninovykh nukleotidov dlia prognozirovaniia soderzhaniia AMF v mozge pri gipoksii.

The empirical relationship between the changes of the AMP concentration and the AMP content under different kinds of hypoxia was showed. This relationship is determined by the function which is closely related to the totality parameters of the brain energy metabolism. This function may be used for the prognosis of the brain energy state under hypoxia.

[Mathematical estimation of enzymic interrelations in brain mitochondria]. / Matematicheskaia otsenka fermentativnykh vzaimootnoshenii v mitokhondriiakh mozga.

Results are presented of mathematical analysis of succinate dehydrogenase and NADH-dehydrogenase activities in mitochondria of rabbit brain. The type of the function describing the correlation between the enzymes is found to be independent of changes in the environments.