ABSTRACT
The article analyzes the results of studying the effects of antihypertensive treatment with the use of agonists dopamine receptors on clinical and hemodynamic and neurohumoral indicators in hypertensive patients with concomitant obesity. Special role is given to the patogenetice factor as dopamine and his relationship with the renin - angiotensin.- aldosterone system, endothelial function, which are aimed at the regulation of blood pressure and obesity formation and progression.
Subject(s)
Amlodipine/therapeutic use , Antihypertensive Agents/therapeutic use , Bromocriptine/therapeutic use , Dopamine Agonists/therapeutic use , Hypertension/drug therapy , Obesity/drug therapy , Adult , Aldosterone/blood , Angiotensin II/blood , Blood Pressure/drug effects , Body Mass Index , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Cholesterol, VLDL/blood , Dopamine/blood , Female , Humans , Hypertension/blood , Hypertension/complications , Hypertension/physiopathology , Male , Middle Aged , Obesity/blood , Obesity/complications , Obesity/physiopathology , Receptors, Dopamine/metabolism , Renin-Angiotensin System/drug effects , Triglycerides/bloodABSTRACT
The authors presents in the article information on influence of endothelial dysfunction and level of blood leukocytes with clinical course of stable angina pectoris in patients with ischemic heart disease (IHD). 104 male patients aged from 36 to 69 (on average 54.9+/-2.1 years) with IHD and stage I-III stable angina pectoris have been observed. The level of leukocytes, ECG daily monitoring, endotelial function with the help of Celermaera-Sorensena test and plasma concentration of endothelin I have been studied in patients. It was established that there is no significant different (P>0.05) in the level of leukocytes between health persons and patients with IHD independently of functional class of angina pectoris. Patients with IHD had higher level of endothelin I in their blood serum than those in a control group. Patients with IHD have a complicated endothelial-non-dependent vasodilation and an increased thickness of the complex intima-media, there is a negative correlation bond between these characteristics. Patients III functional class of angina pectoris has also reliably decreased endothelial-dependent vasodilation by 37%. Frequency of ventricular extrasystoles in patients with IHD and endothelial dysfunction increases by 12 times.
