[Clinicohemadynamic and biochemical the effect of patients with coronary heart disease use combinated lactoovovegetarian diets and simvastatin].

This work is aimed at studying the effect of a lactoovovegetarian antiatherogenic well-balanced diet, combined with the hypolipidemic drug simvastatin, on clinicohemodynamic and biochemical parameters of patients with coronary heart disease and pronounced hypercholesterolemia (TC > 7.8 mmol/l). 43 patients suffering from coronary heart disease, stenocardia under loading (functional classes II-IV) were observed. The patients of the first group (n=17) were had an antiatherogenic vegetarian diet, the patients of the second group (n=26) had the antiatherogenic mixed diet IOC. Besides a standard antianginal therapy all the patients received simvastatin in a daily doze of 20 mg. By the end of the treat ment positive changes in clinicogemodynamic and biochemical parameters were methobolism lipid observed in both the groups of patients. The comparison of lipid parameters revealed a significant and reliable decrease in the first group.

[The treatment of coronary heart disease by beta-adrenoblockers or tiazide diuretics preparation in combination with vegetarian diet].

Work make on 84 patients with coronare heart diseases were divided into two groups, equal quantity. The first groups were given athenolol (50 mg daily), the second--hypotiazide (25 mg daily). In every groupspart patients received an antiatherogenic lactoovovegetetarian diet, part--an standard antiatherogenic diet 10c. Time observation--24 daily. By the end of the treatment period with athenolol in backoground the vegetarian diet the level of total cholesterol decreased by 16%, low-density lipoproteins cholesterol decreased by 18%. In groups patients received an standard antiatherogenic diet these parameters practically did'nt change. In the vegetarian group the atherogenic coefficient (KA) decreased by 31%., while in the patients on standard antiatherogenic diet KA showed only a tendency for decreasing. By the end to the treatment period with hypotiazide the slight decrease in total cholesterol, KA levels and a slight increase in HDL cholesterol were observed only the vegetarian group.

[Leveling the hyperlipidemic effect of beta-adrenoblockers by means of antiatherogenic vegetarian diet]. / Nivelirovanie giperlipidemicheskogo deistviia beta-adrenoblokatorov s pomoshch'iu antiaterogennoi vegetarianskoi diety.

The purpose of the study was to examine the capacities of correction of impaired lipid metabolism in patients with CHD receiving selective beta-adrenoblockers (beta-AB) by using an antiatherogenic milk-and-vegetable diet. According to the type of antiatherogenic diet, 67 patients were divided into 2 groups: 1) 42 patients were on an antiatherogenic vegetarian diet (a vegetarian group--VG) and 2) 25 patients received routine mixed diet No. 10c (a control group--CG). At the same time all the patients received similar antianginal drug therapy including the selective beta-AB atenolol in a dose of 50 mg/day. The vegetarian diet without special hypolipidemic therapy had a marked normalizing effect on the serum lipid spectrum in patients with CHD. Thus, in VG, by the end of treatment, the level of total cholesterol significantly decreased by 16% while in the controls it increased by 13%. High-density lipoprotein cholesterol increased in VG and decreased in CG, therefore the atherogenicity coefficient considerably rose. These were true for triglycerides and very low-density lipoprotein cholesterol. These parameters significantly decreased in VG (by more than 30%) and increased in CG (by 16%). Among the clinical symptoms, a more pronounced decrease in blood pressure in the patients on vegetarian diet and a more significant increase in their exercise tolerance. Balanced antiatherogenic milk-and-vegetable diet in patients with coronary heart disease prevents the hyperlipidemic effect caused by the selective beta-AB atenolol and it is an agent for preventing its negative effect on lipid metabolism.

[Estimation of action of lactoovovegetarian and vegan diets on blood level of atherogenic lipoproteins in healthy people]. / Otsenka deistviia laktoovovegetarianskoi i veganskoi diet na uroven' aterogennykh lipoproteidov krovi u zdorovykh liudei.

The biochemical status of 72 vegetarians (aged 40-60) was studied; 35 persons kept to a lactoovovegetarian diet and 37 persons followed a vegan diet (vegetable food only). As the results of the investigation showed, almost all of the biochemical parameters of blood tests in the both groups were kept to the physiological norm. A pronounced hypolipidemic effect of both the diets was observed (the total cholesterol level was 5.24 +/- 0.28 mmol/l in the vegetarian group and 3.26 +/- 0.17 mmol/l in the vegan group), some parameters of lipid metabolism in the group of vegan being lower then in the vegetarian group. Thus, the total cholesterol level in the vegan group was lower by 38.7%, the atherogenic coefficient--by 13.8%, the low density cholesterol--by 34.3%, triglicerides--by 28.3%. Although the above mentioned parameters of the vegan group seem to be more satisfactory than those of the vegetarian group, we could not recommend the vegan diet for long periods of time because of deficiency of some nutrients in it.

[Results of a dynamic study on the status of health and nutrition of a Siberian vegan settlement]. / Rezul'taty dinamicheskogo nabliudeniia za sostoianiem zdorov'ia i pitaniem Sibirskogo poseleniia veganov.

In 1996 for the first time a study of state of health, living conditions and nutrition status of 84 persons from the Siberian settlement of the rigorous vegetarians--vegans and 26 aboriginal inhabitants who feed on a traditional mixed diet was carried out. The clinical and laboratory investigations are kept. The positive influencing vegan ration on a serum lipids, body weight, state of cardiovascular system was showed. The contents of vitamin B12 and serum iron in vegans was in normal physiological range. The level of blood calcium was reduced in comparison with control. Increased contents of copper and zinc in blood was marked both in vegans and in control group. The repeated examination of 77 vegans of the same settlement in 1999 has revealed positive alterations in serum lipids: augmentation of cholesterol of high density lipoproteins on the average on 54.3%, that result in a reliable decrease of atherogenicity coefficient. The decrease to normal amounts of blood copper and zinc, and also increase of blood calcium on the average on 16% was marked. However level of calcium remained below than physiological values.

[Blood lipids and intensity of free radical oxidant processes in elderly patients with ischemic heart disease on antiatherogenic vegetarian diet]. / Lipidy krovi i intensivnost' svobodnoradikal'nykh okislitel'nykh protsessov u bol'nykh ishemicheskoi bolezn'iu serdtsa pozhilogo vozrasta na fone antiaterogennoi vegetarianskoi diety.

The authors studied the effects of balanced antiatherogenic vegetarian diet enriched with soya bean products on blood lipids and intensity of free radical oxidant processes in elderly patients with ischemic heart disease. 45 patients with dyslipoproteinemia type IIA or IIB were examined for hemodynamic parameters, lipid spectrum and intensity of free radical oxidation. The diet promoted a trend to normalization of central hemodynamics, significantly reduced the level of atherogenic lipids in blood, improved free radical lipid peroxidation and activity of nonenzymatic antioxidant defence.

[The effect of an antiatherogenic vegetarian diet on the clinico-hemodynamic and biochemical indices in elderly patients with ischemic heart disease]. / Vliianie antiaterogennoi vegetarianskoi diety na kliniko-gemodinamicheskie i biokhimicheskie pokazateli bol'nykh ishemicheskoi bolezn'iu serdtsa pozhilogo vozrasta.

AIM: To study the effects of newly developed antiatherogenic vegetarian diet enriched with soya bean products on clinico-hemodynamic characteristics of elderly patients with coronary heart disease (CHD). MATERIALS AND METHODS: Clinico-hemodynamic parameters, lipid blood spectrum and plasmic hemostasis were studied in 28 elderly CHD patients divided into groups by dyslipidemia type (IIA, IIB, IV). RESULTS: The antiatherogenic vegetarian diet promoted normalization of central hemodynamics, lowering of blood atherogenic lipids, positive changes in blood rheology. CONCLUSION: The proposed balanced antiatherogenic vegetarian diet proved to be an effective monotherapy of dyslipidemia in elderly patients with coronary heart disease.

[Data from an expedition to study a Siberian vegan settlement]. / Materialy ékspeditsionnogo issledovaniia sibirskogo poseleniia veganov.

Health status, the way of life and nourishment of 84 vegans in Siberian village (Krasnoyarsk region) were studied and compared with those of 26 meat-eaters. The investigation included work with a questionnaire, clinico-diagnostic and laboratory research. It was shown that a vegetarian diet improves the serum lipid spectrum (cholesterol, LPLD, cholesterol of LPNP, atherogenic coefficient), normalizes weight and cardiovascular system. The vegans had normal levels of vitamin B12 and serum Fe but the calcium level in this group was lowered as compared with the control group. The pathology of internals (nephroptosis, lithic diathesis, tendency to lithogenesis) was observed. Apparently, the high serum Zn levels found in both groups aren't directly caused by the diet but by climate and geographic factors.

[Effects of drug therapy on serum lipids and plasma hemostasis in aged patients with ischemic heart disease on different diets]. / Analiz deistviia medikamentoznoi terapii na lipidnyi spektr krovi i plazmennyi gemostaz bol'nykh ishemicheskoi bolezn'iu serdtsa pozhilovogo vozrasta na fone razlichnykh ratsionov pitaniia.

The effects of antianginal and hypolipidemic therapy on biochemical status and plasmatic hemostasis were studied in 57 aged patients with ischemic disease. The study group (n = 19) got the vegetarian diet (VA-IIIG) enriched with soya-based products. The control 38 patients were on conventional mixed diet including meat, fish and poultry (A-1). It is shown that the vegetarian diet promotes normalization of lipid serum spectrum and plasmatic hemostasis. Inclusion of atherogenic vegetarian diet in the treatment of aged patients considerably improves the effect of antianginal and hypolipidemic therapy.

[The results of exposure to an antisclerotic vegetarian diet enriched with soy-based products on patients in the secondary prevention of ischemic heart disease]. / Rezul'taty vozdeistviia protivoskleroticheskoi vegetarianskoi diety, obogashchennoi produktami pererabotki soi, na bol'nykh pri vtorichnoi profilaktike ishemicheskoi bolezni serdtsa.

The effects of an atherogenic vegetarian diet enriched by soya-based products were investigated for the first time in this country. Clinical status and biochemical parameters of 32 patients suffering from coronary heart disease were studied. Groups 1, 2 and 3 were on the diet for 11-17, 19-22 and 30-40 days, respectively. Hyperlipidemic medicines were discontinued. The vegetarian diet resulted in normalization of the serum lipid spectrum. The most pronounced effect was achieved in group III. The developed vegetarian diet neutralized the adverse effects (an increase of cholesterol and triglycerides) of beta-blockers.

[Balanced vegetarian diet in combined rehabilitation of patients suffering from ischemic heart disease]. / Opyt ispol'zovaniia sbalansirovannoi vegetarianskoi diety v kompleksnoi reabilitatsii bol'nykh izhemicheskoi bolezn'iu serdtsa.

The clinical status of 30 patients suffering from ischemic heart disease, their serum lipids and other biochemical parameters, exercise tolerance were studied. 20 patients from the group were on a specially developed antiatherosclerosis vegetarian diet VA-1; the control group comprised 10 patients who had a mixed diet A-1. It is shown that the vegetarian diet used made it possible to normalize the serum lipid spectrum, the levels of the blood pressure, to increase the tolerance to exercise, to eliminate functional disturbances of the digestive system. The investigation demonstrated the effectiveness of the vegetarian diet as a means of rehabilitation of patients suffering from ischemic heart disease.

[Feasibility of correcting lipid metabolism in patients with cardiovascular diseases using a balanced vegetarian diet]. / Vozmozhnosti korrektsii obmena lipidov u bol'nykh s serdechno-sosudistoi patologiei s pomoshch'iu sbalansirovannoi vegetarianskoi diety.

The spectrum of lipids in 20 patients with dyslipoproteinemia type IIa and IIb (group I and group II) was studied. The patients were treated for 24 days with a lactoovovegetarian diet used for the first time in the country. No drugs were employed. A decrease in the levels of cholesterol, atherogenic lipoproteins and atherogenic coefficient was observed after the treatment. The patients, who were offered a questionnaire highly appreciated the diet.

[Electrophoretic separation of lipoproteins on Vladipor membranes]. / Elektroforeticheskoe razdelenie lipoproteidov na membranakh "Vladipor".

Vladipor cellulose acetate membranes of various make for electrophoretic separation of lipoproteins are compared, the procedure of the membrane treatment and lipoprotein fractionation is described. Electrophoretic fractionation of human blood serum lipoproteins has been found most effective with the use of the MPA-MA Nos. 4 and 5 membranes.

[Importance of a nutritional factor in the changes in carbohydrate and lipid metabolism in a human under neuro-emotional stress]. / Znachenie alimentarnogo faktora v izmenenii uglevodnogo i lipidnogo obmenov u cheloveka pri nervno-émotsional'nom napriazhenii.

Two experiments were performed on 16 test subjects (13 men and 3 women) to study stress-effects on the blood content of sugar and cholesterol. The test subjects were given a nutritionally balanced diet of canned food-stuffs. The caloric value of the diet was adequate to energy expenditures. In the first experiment, the test subjects were also given vitamin E, nicotinic acid and other vitamins constituting the polyvitamin complex Aerovit. In the second experiment, they were additionally supplemented with calcium and potassium salts, glucose and phosphatid concentrate. The stress-agent was a test in the rotating chair in the first experiment and a psychologic test (mental work within a limited period of time to reach success or failure) in the second experiment. The content of sugar and cholesterol before and after the stress-effects did not differ significantly. This can be attributed to the prophylactic effect of the nutritional factor on carbohydrate and lipid metabolism in an emotionally stressed man.

[Lipid metabolic indices in man during head-down tilt hypokinesia and their correction]. / Nekotorye pokazateli lipidnogo obmena u cheloveka v usloviiakh antiortostaticheskoi gipokinezii i ikh korrektsiia.

Twenty one test subjects exposed to head-down tilt for 120 days were subdivided to four groups: Group 1--nine subjects used as controls, Group 2--three bed rested subjects who performed regular exercises, Group 3--four bed rested subjects who were given selected drugs, including Vitamin F-99 that influenced lipid metabolism, and Group 4--four bed rested subjects who performed regular exercises and received Vitamin F-99. At different stages of bed rest and recovery the content of lipoprotein fractions and lipids of different classes in serum was measured by thin-layer chromatography. The concentration of cholesterol in biliary lipids was determined. In Group 1 and 2 subjects bed rest led to a drastic and significant increase of cholesterol esters in blood, a decrease of phospholipids, variations of triglycerides and non-esterified fatty acids, and a lower percentage content of alpha-lipoproteins. The use of Vitamin F-99 produced positive changes in the above parameters of lipid metabolism (it normalized the level of cholesterol and phospholipids). In Group 4 subjects the effect of exercise combined with drugs was most distinct.

[Effect of increased ammonia concentrations in the atmosphere of closed chambers on various indicators of nitrogen and carbohydrate metabolism in men on controlled diets]. / Vliianie povyshennogo soderzhaniia ammiaka v atmosfere germoob'ema na nekotorye pokazateli azotistogo i uglevodnogo obmena u cheloveka na fone reglamentirovannogo pitaniia.

This paper presents data on nitrogen and carbohydrate metabolism in men kept in an enclosed environment with a high ammonium content (2 and 5 mg/m3) combined with a high temperature and humidity. The toxic environmental effect manifests itself when the ammonium concentration increases up to 5 mg/m3 in combination with a high temperature and humidity level. During this period protein catabolism and negative nitrogen balance enhance. It is recommended that vitamins should be added to the diet used under the above conditions.