[Peculiarities of heart risk in patients with non - alcoholic fatial liver disease].

AIM: The purpose of the study is to assess the characteristics of heart risk variability in patients with non - alcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: The study included 103 patients. All patients were divided into three groups. The first group is 34 healthy patients. The second group - 34 patients with a diagnosis of coronary artery disease; exertional angina II-III FC. The third group - 35 patients diagnosed with NAFLD and type 2 diabetes. An assessment of abdominal circumference, body mass index, ALT, AST, XC, HDL, LDL, TG, glucose and the level of glycated hemoglobin (HbA1c), liver ultrasound and daily ECG monitoring with the determination of HRV were evaluated. Evaluated HRV using statistical analysis: avNN, ms; pNN 50%; SDNNidx, ms; SDNN, ms; SDNNidx, ms; RMSSD, ms. HRV characteristics were evaluated: VLF, LF, HF, LF/HF. RESULTS: Compared with the first group, the increase in cholesterol in patients in the second group was noted by 38.8%, in the third group - by 43.7%, TG - by 34.6 and 41.95%. In patients with NAFLD + DM of the second type, SDNN and SDNNidx decreased in comparison with the healthy patients by 15% (p.

Interrelation secretory activity of stomach and immunes changes of peripheral blood when ulcerogenesis stomach.

Incidence of gastric ulcer is high in almost all countries of the world. On the development and course of the disease affect the state acid- and enzymes production stomach, immune status. The purpose was to determine the presence and power of correlative links secretory activity of the stomach and immune changes in the peripheral blood during exacerbation of ulcer disease stomach. Methods: Surveyed in obtaining informed consent 42 patients with gastric ulcer in the acute phase prior to the eradication and antisecretory therapy and 40 healthy volunteers. On the state of function acid- and enzymes production of the gastric mucosa judged by the results of a 2-hour intragastric pH-metry and serum concentration pepsinogen, gastrin before the start of active treatment. Immunophenotype lymphocytes on CD-antigens (CD3, CD4, CD8, CD16, CD19, CD45, CD56) was measured by immunofluorescence, levels immunoglobulin isotype M, G, A, E - ELISA method. Results: When short-term intragastric pH-metry of the stomach hyperacidity patients recorded 6.7 times more likely than healthy, normacidity - 12.3 times less. Reduction of acid production was observed up to 8.6 times more, indicating the development of mucosal atrophy. Basal pH in the antrum was lower by 54.5% than in the control group, with stimulation increased by 33.6%, but remained lower than the values of healthy individuals by 48.7%. When ELISA amount pepsinogen patients showed significant increase in serum levels of PG-I relative to the control group at 33.4%, PG-II - 52%. In assessing the immune status of patients were identified changes in system phagocytes, cellular and humoral links, most pronounced for severe current peptic ulcer disease. Conclusion: The results indicate the presence of positive and negative correlative links mild to moderate force between indicators of secretory activity of gastric mucosal innate and adaptive immunity in patients with acute exacerbation of peptic ulcer disease. The presence and nature of these relationships should be taken into account when appointing antisecretory drugs.

A cohesive European policy for hepatitis B vaccination, are we there yet?

Despite the availability of safe and effective hepatitis B virus (HBV) vaccines for more than 30 years, the burden of hepatitis B disease is still substantial. In 1992, the WHO recommended the inclusion of HBV vaccination in all national vaccination programmes. As of 2012, 47 of the 53 European countries (89%) had implemented a universal hepatitis B vaccination programme. The most recent countries to follow the recommendation were Ireland (in 2008) and the Netherlands (in 2011). Still, six countries (Denmark, Finland, Iceland, Norway, Sweden and the UK) adopt risk-group-targeted vaccination only, instead of adding a universal vaccination programme. However, changing demography, increasing immigration and the current vaccine costs make the cost­benefit ratios in these remaining low endemicity countries strongly in favour of universal HBV vaccination. Global efforts, including a cohesive European vaccination policy, are essential to control and prevent hepatitis B.

[The changes in serum concentrations of interleukin-17 in diseases gastroduodenal zone].

THE PURPOSE OF THE STUDY: Identify on patients with chronic gastritis, peptic ulcer disease, gastric cancer, serum concentrations of interleukin-17 and its relationship to clinical and morphological and serological characteristics. MATERIAL AND METHODS: A comprehensive survey of 156 patients with diseases gastroduodenal zone. Diagnostic emphasis was placed on ELISA method as defined in the serum of IL-17, pepsinogen-I, - II, total antibodies to CagA Helicobacter pylori. RESULTS: In studied patients revealed changes in the concentration of interleukin-17 correlate with the stage of atrophy of the gastric mucosa, tumor, level of pepsinogen, antibodies to the Helicobacter pylori. CONCLUSION: The data obtained allow to recommend the use of interleukin-17 in serological differential diagnosis of diseases gastroduodenal zone.

[Serum interleukin-18 level in precancerous conditions and gastric cancer].

UNLABELLED: The purpose of the study--to determine the serum concentration and the pathogenetic significance of changes of interleukin-18 in patients with chronic atrophic gastritis, peptic ulcer disease and gastric cancer. MATERIAL AND METHODS.:A comprehensive survey of 192 patients with diseases gastroduodenal zone. Diagnostic emphasis was placed on ELISA method as defined in the serum of IL-18, --1beta, interferon-gamma, kantsernogo antigen 19-9, vascular endothelial growth factor, total antibodies to CagA Helicobacter pylori. RESULTS: We examined patients revealed an increase in the concentration of interleukin-18, which correlated with tumor stage, the level of vascular endothelial growth factor, total antibodies to CagA Helicobacter pylori. CONCLUSION: The data obtained allow to recommend the use of interleukin-18 in serum for diagnostic of atrophic gastritis, peptic ulcer diseases and gastric cancer.

[Antiarrhythmic therapy of paroxysmal tachycardias and extrasystoles in patients with sinus node dysfunction].

Antiarrhythmic therapy of patients with disturbed automatism of the sinus node and impaired atrioventricular conductance may be complicated by hemodynamically significant bradycardias and contraindications for implantation of a cardiac electrical stimulator This study aimed at estimating effect of antiarrhythmic therapy with allapinin on the function of sinus and atrioventricular nodes. It included 20 patients (mean age 37.5+-2.3 years) with disturbed cardiac rhythm and sinus node dysfunction treated with allapinin (37.5 - 50 mg/d per os). This therapy had well apparent antiarrhythmic effect manifest as improvement of supraventricular and ventricular ectopic activities in the absence of negative influence on the function of sinus and atrioventricular nodes.

[The role of interleukin-1 and associated cytokines in gastric carcinogenesis].

This review presents detailed analysis of scientific data on influence of the associated with interleukin-1 cytokines on the development of malignant tumors of stomach with the definition of spectrum of diagnostic and therapeutic possibilities. Cytokines associated with interleukin-1 directly and indirectly involved into gastric carcinogenesis. Implementation of pro- and contreoncogenic effects depends on many factors. The serological and genetic criteria changes of interleukin-1 have high diagnostic value and prognostic significance opening new differential approaches to the treatment of precancer conditions and gastric cancer.

[Parameters of oxidative stress in patients with gastric cancer].

We studied effect of the neoplastic process and surgical treatment on parameters of the oxidative system in patients with stomach cancer including serum and gastric tissue levels of malonic dialdehyde, lactic and pyruvic acids in stage I-IV malignancy before and after radical surgery. The development and generalization of the neoplastic process are associated with the activation of oxidative reactions leading to endotoxicosis. Specific anticarcinogenic treatments (including surgery) aggravate changes in the oxidative systems and further deteriorate quality of life and tolerance of the treatment.

[Efficacy of nebivolol in patients with coronary heart disease and concomitant chronic obstructive pulmonary disease].

The study was designed to assess clinical efficiency and safety of nebivolol in patients with cardiovascular problems and chronic obstructive pulmonary disease. It included 50 patients of whom 25 were given daily 5 and 25 mg of nebivolol and 80-100 mg of verapamil. Nebivolol was shown to significantly reduce arterial pressure, heart rate, and the number of ventricular extrasystoles. The drug was well tolerated by the patients and had no adverse effect on bronchial patiency.

[Peculiarities of stress erosive ulcerous injuries of stomach and small intestine].

AIM: The aim of this investigation is to estimate the role of systemic injuries of lipid metabolism in pathogenesis of ulceration on the model of stress ulcerogenesis. MATERIALS AND METHODS: There have been assumed as a basis of the work experimental investigations on 60 pubertal white rats of both sexes weighing 200 gr. There was studied the state of macroscopic picture of stomach and small intestine, qualitative and quantitative lipid composition, lipid peroxidation, phospholipase A2, catalase, superoxide dismutase in stomach tissues, small intestine and blood plasma. RESULTS: The facts of the experimental investigations show, that by the effect of ulceration stress there are processes, that underlie modifications of lipid components of cell structures' biomembranes, and registered by qualitative and quantitative changes of lipid composition. Intensification of lipid peroxidation and activation of phospholipase A2 are the key mechanisms of qualitative and quantitative composition of biomembranes' lipid components, and they reduce to beginnings of cascade of pathomorphological and pathophysiological reactions in cell structures, which cause beginnings of membrane destructive processes, that is as a basis of ulcerogenesis. CONCLUSION: In the result there is broken morphofunctional state of mucous membrane (one of the main factors of protection), that in the end makes it accessible substratum for other aggressive factors and promotes the formation of ulcerous defects.

[Clinical condition of patients with persistent form of atrial fibrillation before and after cardioversion].

The aim of the study was to examine effect of cardioversion (CV) on the subjective and objective status of patients with persistent atrial fibrillation (AF) receiving different therapy. The study included 4 groups of patients (n = 85). Group 1 (n = 30) were given standard treatment. In group 2 (n = 25), standard therapy was supplemented by i.v. injections of emoxipin (200 mg/day). Treatment of group 3 (n = 10) included mildronat (50 mg/day, i.v.), patients of group 4 (n = 20) were given riboxin (200 mg/day, i.v.). It was shown that the recovery of sinus rhythm improved the quality of life and parameters of cardiovascular function in all the treated patients.

[Prevention of ulcerogenesis at experimental pancreatitis].

OBJECTIVE: We wanted to study the mechanisms of "Dimefosfon" influence on ulcerogenesis prevention in acute pancreatitis. MATERIALS AND METHODS: The study was conducted on 36 dogs. We were modeling of edematous form of pancreatitis: fulfilled the median laparotomy, punctured of the gall bladder bile were taken, it was administered at 5 points of the pancreas parenchyma to 0.5 ml. The animals of experimental group on a daily basis once a day for 5 days were administered intravenously 15% solution of dimefosfon the rate of 50 mg/kg body weight. In the tissues of the duodenum was examined the intensity of lipid peroxidation, determined indicators of hypoxia, transcapillar exchange and bioenergy, and conducted their microscopic examination. RESULTS: Dimefosfon helped to reduce the severity of inflammation in the pancreas parenchyma, as well as the destructive changes in the duodenum. Dimefosfon effectiveness in correction of microcirculation, trophic system and bio-energy disorders in the tissues of intestine was shown by the third day of the drug using. At this period the capillary filtrate, the diffusion coefficient of oxygen, the rate of electrogenesis duodenal tissues significantly exceeded results of the control group study. Indicator protein loss wasn't significantly different from controls. Efficiency of dimefosfon in correction indicators of hypoxia was also seen with the third day of therapy. In duodenal tissue during this period there was a decrease of lactate and pyruvic acid as compared with control. Significant changes in indicators of intensity of lipid peroxidation and the activity of phosfolipase A2 in duodenal tissues were observed on the third day of dimefosfon using. At this stage of observation resultes were compared with the control and had decreased of malondialdehyde content and activity of phosfolipase A2. Catalase activity was lower compared with the control and did not differ from the norm. CONCLUSION: One of the ulcerogenesis mechanisms in duodenum in acute pancreatitis is a violation of microcirculation, deterioration trophics tissues of the intestinal wall that contribute to the launch of free radical reactions and lead to membranodestructive processes in the intestinal mucosa. Dimefosfon has cytoprotect effect as a result of decreased activity of lipid peroxidation and restoration of microcirculation and trophics tissues of intestinal wall. Positive therapeutic effect of the drug was observed with the third day of therapy.

[Ulcer genesis and endogenous intoxication].

In the experiment it has been established, that during the influence of the ulcerous factor there develops the syndrome of endogenous intoxication. It is characterized by changes of hydrophilous and hydrophobic components: the increase of the toxicity index of plasma, molecules of medium mass, decrease of the common and effective concentration of albumin, reserve of connecting the albumin. There has been observed modifications of the main lipid components, cell biomembranes of the stomach, which as a whole testify to the process of destabilizing of membranes. The degree of expressivity of processes destructing the membranes in the stomach tissue has been reflected also on the organism level (in the blood plasma).

[The efficacy of complex therapy of ventricular arrhythmias with emoxipin and preductal in combination with antiarrhythmic agents].

Forty-five patients with coronary heart disease and various forms of ventricular arrhythmias (25 men and 20 women aged 42 to 73) were examined. The use of complex therapy with emoxipin and preductal in a combination with antiarrhythmic agents potentated the action of these preparations. The application of emoxipin resulted in a longer positive effect.

[Dimephosphon in complex therapy of acute edematous pancreatitis]. / Dimefosfon v kompleksnoi terapii ostrogo otechnogo pankreatita.

Clinical investigations of 120 patients have shown that Dimephosphon included in complex treatment of acute edematous pancreatitis facilitates more rapid arrest of the symptoms. An important effect of the drug is its ability to decrease the level of endogenous intoxication by both the hydrophilic and hydrophobic components. It was established that one of the mechanisms of favorable action of the drug is its ability to inhibit LPO, to decrease activity of phospholipase A2. The drug possessing the cytoprotecting effect promotes rapid restoration of the functional state of the liver, in particular its detoxicating, albumin synthesizing ability that is not least of the factors of optimization of the complex therapy.